Structural mimicry of retroviral tat proteins by constrained beta-hairpin peptidomimetics: ligands with high affinity and selectivity for viral TAR RNA regulatory elements.
about
Simultaneous recognition of HIV-1 TAR RNA bulge and loop sequences by cyclic peptide mimics of Tat proteinEssential structural requirements for specific recognition of HIV TAR RNA by peptide mimetics of Tat proteinInhibition of both HIV-1 reverse transcription and gene expression by a cyclic peptide that binds the Tat-transactivating response element (TAR) RNATargeting RNA with cysteine-constrained peptides.A single intermolecular contact mediates intramolecular stabilization of both RNA and proteinmicroRNA machinery is an integral component of drug-induced transcription inhibition in HIV-1 infection.Cyclic peptides as therapeutic agents and biochemical tools.A Macrocyclic Peptide Ligand Binds the Oncogenic MicroRNA-21 Precursor and Suppresses Dicer Processing.How binding of small molecule and peptide ligands to HIV-1 TAR alters the RNA motional landscape.Design of beta-hairpin peptidomimetics that inhibit binding of alpha-helical HIV-1 Rev protein to the rev response element RNA.γ-AApeptides bind to RNA by mimicking RNA-binding proteins.The design of RNA binders: targeting the HIV replication cycle as a case study.Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.Attenuating HIV Tat/TAR-mediated protein expression by exploring the side chain length of positively charged residues.Improving combination antiretroviral therapy by targeting HIV-1 gene transcription.The beta hairpin structure within ribosomal protein S5 mediates interplay between domains II and IV and regulates HCV IRES function.Artificial nucleobase-amino acid conjugates: a new class of TAR RNA binding agents.Microwave-assisted solid-phase synthesis of side-chain to side-chain lactam-bridge cyclic peptides.Molecular dynamics and MM/GBSA-integrated protocol probing the correlation between biological activities and binding free energies of HIV-1 TAR RNA inhibitors.Coupling the folding of a β-hairpin with chelation-enhanced luminescence of Tb(III) and Eu(III) ions for specific sensing of a viral RNA.TAR-RNA recognition by a novel cyclic aminoglycoside analogue.On the design of zinc-finger models with cyclic peptides bearing a linear tail.An l-RNA Aptamer with Expanded Chemical Functionality that Inhibits MicroRNA Biogenesis.Superior HIV-1 TAR Binders with Conformationally Constrained R52 Arginine Mimics in the Tat(48-57) Peptide.A Thioether-Stabilized d-Proline-l-Proline-Induced β-Hairpin Peptide of Defensin Segment Increases Its Anti-Candida albicans Ability.
P2860
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P2860
Structural mimicry of retroviral tat proteins by constrained beta-hairpin peptidomimetics: ligands with high affinity and selectivity for viral TAR RNA regulatory elements.
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Structural mimicry of retrovir ...... l TAR RNA regulatory elements.
@ast
Structural mimicry of retrovir ...... l TAR RNA regulatory elements.
@en
type
label
Structural mimicry of retrovir ...... l TAR RNA regulatory elements.
@ast
Structural mimicry of retrovir ...... l TAR RNA regulatory elements.
@en
prefLabel
Structural mimicry of retrovir ...... l TAR RNA regulatory elements.
@ast
Structural mimicry of retrovir ...... l TAR RNA regulatory elements.
@en
P2093
P356
P1476
Structural mimicry of retrovir ...... l TAR RNA regulatory elements.
@en
P2093
Gabriele Varani
John A Robinson
Kerstin Moehle
Neil Dobson
Ricardo L A Dias
Zafiria Athanassiou
P304
P356
10.1021/JA0497680
P407
P577
2004-06-01T00:00:00Z