Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.
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Synthetic Peptides as Protein MimicsMulti-Facial, Non-Peptidic α-Helix MimeticsDouble Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled PeptidesConstraining an Irregular Peptide Secondary Structure through Ring-Closing Alkyne MetathesisRational Structure-Based Rescaffolding Approach to De Novo Design of Interleukin 10 (IL-10) Receptor-1 MimeticsAnti-Hemagglutinin Antibody Derived Lead Peptides for Inhibitors of Influenza Virus BindingTargeting kinase signaling pathways with constrained peptide scaffolds.Fatty acid synthase cooperates with protrudin to facilitate membrane outgrowth of cellular protrusionsDe Novo Modular Development of a Foldameric Protein-Protein Interaction Inhibitor for Separate Hot Spots: A Dynamic Covalent Assembly Approach.Understanding Tetrahydropyranyl as a Protecting Group in Peptide Chemistry.Cytotoxicity of Pyrazine-Based Cyclometalated (C^Npz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties.β-Turn mimetic-based stabilizers of protein-protein interactions for the study of the non-canonical roles of leucyl-tRNA synthetase.Identification of Peptide Inhibitors of Enveloped Viruses Using Support Vector Machine.Probing Protein Surfaces: QSAR Analysis with Helix Mimetics.Rapid Optimization of Mcl-1 Inhibitors using Stapled Peptide Libraries Including Non-Natural Side Chains.Small Molecules Engage Hot Spots through Cooperative Binding To Inhibit a Tight Protein-Protein Interaction.Targeting intracellular protein-protein interactions with cell-permeable cyclic peptides.An optimal hydrogen-bond surrogate for α-helices.Towards "bionic" proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics.Stapled Peptides with γ-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction.New Modalities for Challenging Targets in Drug Discovery.Direct Modulation of Small GTPase Activity and Function.Flexibility is important for inhibition of the MDM2/p53 protein-protein interaction by cyclic β-hairpins.Targeting MYC: is it getting any easier?Designing helical peptide inhibitors of protein-protein interactionsSystematic Targeting of Protein-Protein InteractionsDiscovery and optimization of peptide macrocycles.Peptides and peptidomimetics as regulators of protein-protein interactions.Thioether-Derived Macrocycle for Peptide Secondary Structure Fixation.Targeted Protein Degradation: from Chemical Biology to Drug Discovery.Molecular genetics and targeted therapy of WNT-related human diseases (Review).Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides.Enhancing the Cell Permeability and Metabolic Stability of Peptidyl Drugs by Reversible Bicyclization.Inhibitory mechanism of peptides with a repeating hydrophobic and hydrophilic residue pattern on interleukin-10.Side-Chain Conformational Preferences Govern Protein-Protein Interactions.Peptide-Directed Binding for the Discovery of Modulators of α-Helix-Mediated Protein-Protein Interactions: Proof-of-Concept Studies with the Apoptosis Regulator Mcl-1.Cell penetrating peptides to dissect host-pathogen protein-protein interactions in Theileria-transformed leukocytes.Peptide Macrocyclization Inspired by Non-Ribosomal Imine Natural Products.Controlled inhibition of methyltransferases using photoswitchable peptidomimetics: towards an epigenetic regulation of leukemia.Double quick, double click reversible peptide "stapling".
P2860
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P2860
Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Structure-Based Design of Inhi ...... king Peptide Binding Epitopes.
@en
type
label
Structure-Based Design of Inhi ...... king Peptide Binding Epitopes.
@en
prefLabel
Structure-Based Design of Inhi ...... king Peptide Binding Epitopes.
@en
P2860
P921
P356
P1476
Structure-Based Design of Inhi ...... cking Peptide Binding Epitopes
@en
P2093
Adrian Glas
Marta Pelay-Gimeno
P2860
P304
P356
10.1002/ANIE.201412070
P407
P577
2015-06-26T00:00:00Z