The nonimmunosuppressive cyclosporin analogs NIM811 and UNIL025 display nanomolar potencies on permeability transition in brain-derived mitochondria.
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Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channelsInvestigation of Debio 025, a cyclophilin inhibitor, in the dystrophic mdx mouse, a model for Duchenne muscular dystrophyCyclosporin A corrects mitochondrial dysfunction and muscle apoptosis in patients with collagen VI myopathiesBrain injury following cardiac arrest: pathophysiology for neurocritical careMitochondrial targets for pharmacological intervention in human diseaseBroad-spectrum agents for flaviviral infections: dengue, Zika and beyondMolecular Dissection of Cyclosporin A's Neuroprotective Effect Reveals Potential Therapeutics for Ischemic Brain Injury.Cyclophilin D-sensitive mitochondrial permeability transition in adult human brain and liver mitochondria.Debio-025 is more effective than prednisone in reducing muscular pathology in mdx mice.Reperfusion promotes mitochondrial dysfunction following focal cerebral ischemia in rats.Functional and pharmacological characteristics of permeability transition in isolated human heart mitochondria.Mitochondrial mechanisms of cell death and neuroprotection in pediatric ischemic and traumatic brain injury.ColVI myopathies: where do we stand, where do we go?Cyclosporine A in Ullrich congenital muscular dystrophy: long-term resultsMitochondrial dysfunction in the pathogenesis of Ullrich congenital muscular dystrophy and prospective therapy with cyclosporinsMitochondrial reactive oxygen species at the heart of the matter: new therapeutic approaches for cardiovascular diseases.Cyclophilin D inactivation protects axons in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosisIdentification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria.Mitochondria as a drug target in ischemic heart disease and cardiomyopathyCyclophilin inhibitors in hepatitis C viral infection.Mechanisms of impaired mitochondrial energy metabolism in acute and chronic neurodegenerative disorders.Role of Mitochondria in Neonatal Hypoxic-Ischemic Brain InjuryGenetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy.Mitochondrial abnormalities, energy deficit and oxidative stress are features of calpain 3 deficiency in skeletal musclePostischemic oxidative stress promotes mitochondrial metabolic failure in neurons and astrocytes.Mitochondrial calcium function and dysfunction in the central nervous system.Cyclophilin D in mitochondrial pathophysiology.Targeting mitochondrial function for the treatment of acute spinal cord injury.The role of glutamate in neuronal ischemic injury: the role of spark in fire.The permeability transition pore as a Ca(2+) release channel: new answers to an old question.Targeting mitochondria for cardioprotection: examining the benefit for patients.Lithium desensitizes brain mitochondria to calcium, antagonizes permeability transition, and diminishes cytochrome C release.Cyclophilin D counteracts P53-mediated growth arrest and promotes Ras tumorigenesis.The cyclophilin inhibitor Debio 025 normalizes mitochondrial function, muscle apoptosis and ultrastructural defects in Col6a1-/- myopathic mice.The temperature dependence and involvement of mitochondria permeability transition and caspase activation in damage to organotypic hippocampal slices following in vitro ischemia.Mitochondrial pharmacology: its future is now.Anti-Trypanosoma cruzi effects of cyclosporin A derivatives: possible role of a P-glycoprotein and parasite cyclophilins.Post-Injury Treatment with NIM811 Promotes Recovery of Function in Adult Female Rats after Spinal Cord Contusion: A Dose-Response Study.
P2860
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P2860
The nonimmunosuppressive cyclosporin analogs NIM811 and UNIL025 display nanomolar potencies on permeability transition in brain-derived mitochondria.
description
2004 nî lūn-bûn
@nan
2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
The nonimmunosuppressive cyclo ...... in brain-derived mitochondria.
@ast
The nonimmunosuppressive cyclo ...... in brain-derived mitochondria.
@en
type
label
The nonimmunosuppressive cyclo ...... in brain-derived mitochondria.
@ast
The nonimmunosuppressive cyclo ...... in brain-derived mitochondria.
@en
prefLabel
The nonimmunosuppressive cyclo ...... in brain-derived mitochondria.
@ast
The nonimmunosuppressive cyclo ...... in brain-derived mitochondria.
@en
P2093
P50
P1476
The nonimmunosuppressive cyclo ...... in brain-derived mitochondria
@en
P2093
Gustav Mattiasson
Jean-Maurice Dumont
Jenny Karlsson
Kamel Besseghir
Marcus F Keep
Peter Waldmeier
Roland Månsson
P304
P356
10.1023/B:JOBB.0000041776.31885.45
P577
2004-08-01T00:00:00Z
P5875
P6179
1017833017