A general method for greatly improving the affinity of antibodies by using combinatorial libraries
about
Deletion of Phe508 in the first nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator increases its affinity for the heat shock cognate 70 chaperoneApplications of Yeast Surface Display for Protein EngineeringAffinity maturation of antibodies assisted by in silico modeling.Data-Driven Antibody Engineering Using Genedata Biologics™.Ribosome display for improved biotherapeutic molecules.Optimizing the affinity and specificity of proteins with molecular display.An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10Yeast surface display for protein engineering and characterizationA decade of yeast surface display technology: where are we now?Combinatorial antibody libraries from survivors of the Turkish H5N1 avian influenza outbreak reveal virus neutralization strategiesPredicting protein evolution in vitro by phage escape technology.OptCDR: a general computational method for the design of antibody complementarity determining regions for targeted epitope binding.Aglycosylated antibodies and antibody fragments produced in a scalable in vitro transcription-translation system.Antigen-binding site anatomy and somatic mutations in antibodies that recognize different types of antigens.Femtomolar Fab binding affinities to a protein target by alternative CDR residue co-optimization strategies without phage or cell surface display.Identification of human single-chain antibodies with broad reactivity for noroviruses.Tailored amino acid diversity for the evolution of antibody affinityThe influence of antibody fragment format on phage display based affinity maturation of IgG.Development trends for generation of single-chain antibody fragments.A sequence-specific threading tetra-intercalator with an extremely slow dissociation rate constantHigh-resolution sequence-function mapping of full-length proteins.Effective Optimization of Antibody Affinity by Phage Display Integrated with High-Throughput DNA Synthesis and Sequencing TechnologiesCalcium-dependent antigen binding as a novel modality for antibody recycling by endosomal antigen dissociationSubstitution of Heavy Complementarity Determining Region 3 (CDR-H3) Residues Can Synergistically Enhance Functional Activity of Antibody and Its Binding Affinity to HER2 Antigen.Establishment of cell surface engineering and its development.Development of a biotinylated broad-specificity single-chain variable fragment antibody and a sensitive immunoassay for detection of organophosphorus pesticides.Protease substrate profiling using bacterial display of self-blocking affinity proteins and flow-cytometric sorting.Improved antibody-based ricin neutralization by affinity maturation is correlated with slower off-rate values.Tuning the specificity of a Two-in-One Fab against three angiogenic antigens by fully utilizing the information of deep mutational scanning.Antibody engineering toward high-sensitivity high-throughput immunosensing of small molecules.Engineering the variable region of therapeutic IgG antibodies.Molecular engineering of antibodies for therapeutic and diagnostic purposes.Antibody-antigen pair probed by combinatorial approach and rational design: bringing together structural insights, directed evolution, and novel functionality.Probing binding mechanism of interleukin-6 and olokizumab: in silico design of potential lead antibodies for autoimmune and inflammatory diseases.Methods for the directed evolution of proteins.Arming Technology in Yeast-Novel Strategy for Whole-cell Biocatalyst and Protein Engineering.Deep Sequencing-guided Design of a High Affinity Dual Specificity Antibody to Target Two Angiogenic Factors in Neovascular Age-related Macular Degeneration.Affinity maturation of an anti-V antigen IgG expressed in situ through adenovirus gene delivery confers enhanced protection against Yersinia pestis challenge.Production of biologically active scFv and VHH antibody fragments in Bifidobacterium longum.Biosensor detection systems: engineering stable, high-affinity bioreceptors by yeast surface display.
P2860
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P2860
A general method for greatly improving the affinity of antibodies by using combinatorial libraries
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
A general method for greatly i ...... using combinatorial libraries
@ast
A general method for greatly i ...... using combinatorial libraries
@en
type
label
A general method for greatly i ...... using combinatorial libraries
@ast
A general method for greatly i ...... using combinatorial libraries
@en
prefLabel
A general method for greatly i ...... using combinatorial libraries
@ast
A general method for greatly i ...... using combinatorial libraries
@en
P2093
P2860
P356
P1476
A general method for greatly i ...... using combinatorial libraries
@en
P2093
Arvind Rajpal
Guido Cappuccilli
Helena Yee
Lauric Haber
Nurten Beyaz
Ramesh R Bhatt
Richard A Lerner
Roberto Crea
Toshihiko Takeuchi
P2860
P304
P356
10.1073/PNAS.0503543102
P407
P577
2005-06-06T00:00:00Z