Clavulanic acid inactivation of SHV-1 and the inhibitor-resistant S130G SHV-1 beta-lactamase. Insights into the mechanism of inhibition.
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Three decades of beta-lactamase inhibitorsAsp-120 locates Zn2 for optimal metallo-beta-lactamase activityStrategic Design of an Effective -Lactamase Inhibitor: LN-1-255, A 6-ALKYLIDENE-2'-SUBSTITUTED PENICILLIN SULFONEDesign, Synthesis, and Crystal Structures of 6-Alkylidene-2′-Substituted Penicillanic Acid Sulfones as Potent Inhibitors of Acinetobacter baumannii OXA-24 CarbapenemaseDesign and Exploration of Novel Boronic Acid Inhibitors Reveals Important Interactions with a Clavulanic Acid-Resistant Sulfhydryl-Variable (SHV) β-LactamaseThe Importance of thetrans-Enamine Intermediate as a β-Lactamase Inhibition Strategy Probed in Inhibitor-Resistant SHV β-Lactamase Variantsβ-Lactamase Inhibition by 7-Alkylidenecephalosporin Sulfones: Allylic Transposition and Formation of an Unprecedented Stabilized Acyl-EnzymeInsight into the effect of inhibitor resistant S130G mutant on physico-chemical properties of SHV type beta-lactamase: a molecular dynamics studyTrapping and characterization of a reaction intermediate in carbapenem hydrolysis by B. cereus metallo-beta-lactamase.Why the extended-spectrum beta-lactamases SHV-2 and SHV-5 are "hypersusceptible" to mechanism-based inhibitorsInhibition of OXA-1 beta-lactamase by penems.Different intermediate populations formed by tazobactam, sulbactam, and clavulanate reacting with SHV-1 beta-lactamases: Raman crystallographic evidenceEnhancing resistance to cephalosporins in class C beta-lactamases: impact of Gly214Glu in CMY-2.The role of a second-shell residue in modifying substrate and inhibitor interactions in the SHV beta-lactamase: a study of ambler position Asn276.Penicillin sulfone inhibitors of class D beta-lactamasesExploring the inhibition of CTX-M-9 by beta-lactamase inhibitors and carbapenems.Identification of products of inhibition of GES-2 beta-lactamase by tazobactam by x-ray crystallography and spectrometry.Avibactam and inhibitor-resistant SHV β-lactamasesThe Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition.Engineered mononuclear variants in Bacillus cereus metallo-beta-lactamase BcII are inactive.Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae.Common mechanistic features among metallo-beta-lactamases: a computational study of Aeromonas hydrophila CphA enzyme.The different inhibition mechanisms of OXA-1 and OXA-24 β-lactamases are determined by the stability of active site carboxylated lysine.The role of IgE recognition in allergic reactions to amoxicillin and clavulanic acid.Structural/mechanistic insights into the efficacy of non-classical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates.Homology modeling and virtual screening of inhibitors against TEM- and SHV-type-resistant mutants: A multilayer filtering approach.Rational design of a beta-lactamase inhibitor achieved via stabilization of the trans-enamine intermediate: 1.28 A crystal structure of wt SHV-1 complex with a penam sulfoneIrreversible inhibition of the Mycobacterium tuberculosis beta-lactamase by clavulanate.Following drug uptake and reactions inside Escherichia coli cells by Raman microspectroscopy.Importance of position 170 in the inhibition of GES-type β-lactamases by clavulanic acid.Probing active site chemistry in SHV beta-lactamase variants at Ambler position 244. Understanding unique properties of inhibitor resistance.High resolution crystal structures of the trans-enamine intermediates formed by sulbactam and clavulanic acid and E166A SHV-1 {beta}-lactamase.A fluorescein-labeled AmpC β-lactamase allows rapid characterization of β-lactamase inhibitors by real-time fluorescence monitoring of the β-lactamase-inhibitor interactions.
P2860
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P2860
Clavulanic acid inactivation of SHV-1 and the inhibitor-resistant S130G SHV-1 beta-lactamase. Insights into the mechanism of inhibition.
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Clavulanic acid inactivation o ...... o the mechanism of inhibition.
@ast
Clavulanic acid inactivation o ...... o the mechanism of inhibition.
@en
type
label
Clavulanic acid inactivation o ...... o the mechanism of inhibition.
@ast
Clavulanic acid inactivation o ...... o the mechanism of inhibition.
@en
prefLabel
Clavulanic acid inactivation o ...... o the mechanism of inhibition.
@ast
Clavulanic acid inactivation o ...... o the mechanism of inhibition.
@en
P2093
P2860
P356
P1476
Clavulanic acid inactivation o ...... o the mechanism of inhibition.
@en
P2093
Christopher R Bethel
Deley Sulton
Doritza Pagan-Rodriguez
Jodi M Thomson
John D Buynak
Marion S Helfand
Vernon E Anderson
Xiang Zhou
Yiding Liu
P2860
P304
35528-35536
P356
10.1074/JBC.M501251200
P407
P577
2005-06-29T00:00:00Z