Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5.

Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5.

Item
http://www.wikidata.org/entity/Q33221219
Allosteric drug discrimination is coupled to mechanochemical changes in the kinesin-5 motor core.Pathway of ATP hydrolysis by monomeric kinesin Eg5Pharmacological importance of optically active tetrahydro-β-carbolines and synthetic approaches to create the C1 stereocenterDifferential control of Eg5-dependent centrosome separation by Plk1 and Cdk1BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A.Transition-metal-catalyzed C-H bond functionalizations: feasible access to a diversity-oriented β-carboline library.Dimeric Eg5 maintains processivity through alternating-site catalysis with rate-limiting ATP hydrolysisSynthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective.Synthesis and molecular modeling of six novel monastrol analogues: evaluation of cytotoxicity and kinesin inhibitory activity against HeLa cell line.Kinesin spindle protein inhibitors in cancer: a patent review (2008 - present).Discovery of a novel series of tetrahydro-β-carbolines inducing autophagic cell death in human metastatic melanoma.Synthesis and molecular modeling of novel tetrahydro-β-carboline derivatives with phosphodiesterase 5 inhibitory and anticancer properties.Synthesis of novel tadalafil analogues and their evaluation as phosphodiesterase inhibitors and anticancer agents.Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-β-Carboline Hydantoin and Tetrahydro-β-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors.The diketopiperazine-fused tetrahydro-β-carboline scaffold as a model peptidomimetic with an unusual α-turn secondary structure.
P2860

Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5.

Item
http://www.wikidata.org/entity/Q33221219
description
2005 nî lūn-bûn
@nan
2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Synthesis and biological evalu ...... rs of the mitotic kinesin Eg5.
@ast
Synthesis and biological evalu ...... rs of the mitotic kinesin Eg5.
@en
type
label
Synthesis and biological evalu ...... rs of the mitotic kinesin Eg5.
@ast
Synthesis and biological evalu ...... rs of the mitotic kinesin Eg5.
@en
prefLabel
Synthesis and biological evalu ...... rs of the mitotic kinesin Eg5.
@ast
Synthesis and biological evalu ...... rs of the mitotic kinesin Eg5.
@en
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698
P356
P1433
P1476
Synthesis and biological evalu ...... rs of the mitotic kinesin Eg5.
@en
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698