Differential control of Eg5-dependent centrosome separation by Plk1 and Cdk1 - Wikidata - wikimedia - TriplyDB

Differential control of Eg5-dependent centrosome separation by Plk1 and Cdk1

Differential control of Eg5-dependent centrosome separation by Plk1 and Cdk1

http://www.wikidata.org/entity/Q30501259

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Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancer Kinesin-5: cross-bridging mechanism to targeted clinical therapy Regulation of the centrosome cycle Cross-Talk between AURKA and Plk1 in Mitotic Entry and Spindle Assembly Centrosomes, chromosome instability (CIN) and aneuploidy Aurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindle A critical function of Mad2l2 in primordial germ cell development of mice Plk1 inhibition causes post-mitotic DNA damage and senescence in a range of human tumor cell lines Centrosome/Cell cycle uncoupling and elimination in the endoreduplicating intestinal cells of C. elegans Ipl1/Aurora kinase suppresses S-CDK-driven spindle formation during prophase I to ensure chromosome integrity during meiosis The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation.Nuclear envelope-associated dynein drives prophase centrosome separation and enables Eg5-independent bipolar spindle formation.PCTAIRE1 phosphorylates p27 and regulates mitosis in cancer cells.Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation.Multisite phosphorylation of C-Nap1 releases it from Cep135 to trigger centrosome disjunction Regulatory functional territory of PLK-1 and their substrates beyond mitosis.Centaurin-α₂ interacts with β-tubulin and stabilizes microtubules Centrosome dynamics as a source of chromosomal instability Cyclin B2 and p53 control proper timing of centrosome separation Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics.Mio depletion links mTOR regulation to Aurora A and Plk1 activation at mitotic centrosomes Rotavirus replication is correlated with S/G2 interphase arrest of the host cell cycle Mitotic kinase cascades orchestrating timely disjunction and movement of centrosomes maintain chromosomal stability and prevent cancer.An analogue-sensitive approach identifies basal body rotation and flagellum attachment zone elongation as key functions of PLK in Trypanosoma brucei.Chemically diverse microtubule stabilizing agents initiate distinct mitotic defects and dysregulated expression of key mitotic kinases G protein-coupled receptor kinase 2 (GRK2) is localized to centrosomes and mediates epidermal growth factor-promoted centrosomal separation.The benefits of local depletion: The centrosome as a scaffold for ubiquitin-proteasome-mediated degradation Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5.Breaking the ties that bind: new advances in centrosome biology.The centrosome as potential target for cancer therapy and prevention.Polo-like kinases: structural variations lead to multiple functions.Separate to operate: control of centrosome positioning and separation.Genistein-induced mitotic arrest of gastric cancer cells by downregulating KIF20A, a proteomics study.Aurora A, MCAK, and Kif18b promote Eg5-independent spindle formation.Proteomic analysis of cell cycle progression in asynchronous cultures, including mitotic subphases, using PRIMMUS.Centrosome separation; a careful balancing act.Kinesin family member 11 contributes to the progression and prognosis of human breast cancer.Functional analysis after rapid degradation of condensins and 3D-EM reveals chromatin volume is uncoupled from chromosome architecture in mitosis.Three Cdk1 sites in the kinesin-5 Cin8 catalytic domain coordinate motor localization and activity during anaphase.

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P2860

Differential control of Eg5-dependent centrosome separation by Plk1 and Cdk1

http://www.wikidata.org/entity/Q30501259

description

2011 nî lūn-bûn

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2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2011年の論文

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2011年論文

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2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

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2011年论文

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name

Differential control of Eg5-dependent centrosome separation by Plk1 and Cdk1

@ast

Differential control of Eg5-dependent centrosome separation by Plk1 and Cdk1

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type

label

Differential control of Eg5-dependent centrosome separation by Plk1 and Cdk1

@ast

Differential control of Eg5-dependent centrosome separation by Plk1 and Cdk1

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prefLabel

Differential control of Eg5-dependent centrosome separation by Plk1 and Cdk1

@ast

Differential control of Eg5-dependent centrosome separation by Plk1 and Cdk1

@en

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The EMBO Journal

P1476

Differential control of Eg5-dependent centrosome separation by Plk1 and Cdk1

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P2093

Chris Larch

http://www.w3.org/2001/XMLSchema#string

Clare Vesely

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Hansjörg Streicher

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Isaac Roseboom

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Mark Skehel

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Nadia Hégarat

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Ryoko Kuriyama

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Toru Hirota

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P2860

The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion

The mechanism regulating the dissociation of the centrosomal protein C-Nap1 from mitotic spindle poles

The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity

Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction

C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2

Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

Rootletin forms centriole-associated filaments and functions in centrosome cohesion

Mutations in the kinesin-like protein Eg5 disrupting localization to the mitotic spindle

The kinesin-like protein KLP61F is essential for mitosis in Drosophila

P304

2233-2245

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scholarly article

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10.1038/EMBOJ.2011.120

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P433

11

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30

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Helfrid Hochegger

Kornelis Straatman

P577

2011-04-26T00:00:00Z

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51078930

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21522128

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3117641

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