Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells.
about
Cytokines and chemokines at the crossroads of neuroinflammation, neurodegeneration, and neuropathic painPaxillin-Y118 phosphorylation contributes to the control of Src-induced anchorage-independent growth by FAK and adhesion.The direct effect of focal adhesion kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis.Potential of phage-displayed peptide library technology to identify functional targeting peptidesInhibition of focal adhesion kinase and src increases detachment and apoptosis in human neuroblastoma cell linesFocal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasisInhibition of focal adhesion kinase decreases tumor growth in human neuroblastomaFAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cellsTargeting the C-terminal focal adhesion kinase scaffold in pancreatic cancerInhibition of FAK and VEGFR-3 binding decreases tumorigenicity in neuroblastoma.VEGF-C-VEGFR3/Flt4 axis regulates mammary tumor growth and metastasis in an autocrine manner.Targeting focal adhesion kinase in neuroblastoma.Pharmacokinetic analysis of the FAK scaffold inhibitor C4 in dogsAqueous Extract of Paeonia suffruticosa Inhibits Migration and Metastasis of Renal Cell Carcinoma Cells via Suppressing VEGFR-3 Pathway.Design, synthesis, and biological evaluation of novel FAK scaffold inhibitors targeting the FAK-VEGFR3 protein-protein interaction.Combination of heat shock protein 90 and focal adhesion kinase inhibitors synergistically inhibits the growth of non-small cell lung cancer cells.A FAK scaffold inhibitor disrupts FAK and VEGFR-3 signaling and blocks melanoma growth by targeting both tumor and endothelial cellsVascular endothelial growth factor receptor-3 promotes breast cancer cell proliferation, motility and survival in vitro and tumor formation in vivo.A small-molecule inhibitor, 5'-O-tritylthymidine, targets FAK and Mdm-2 interaction, and blocks breast and colon tumorigenesis in vivo.Focal adhesion kinase: a promising target for anticancer therapy.Disrupting the scaffold to improve focal adhesion kinase-targeted cancer therapeuticsFocal adhesion kinase versus p53: apoptosis or survival?Inhibition of the focal adhesion kinase and vascular endothelial growth factor receptor-3 interaction leads to decreased survival in human neuroblastoma cell lines.The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth.Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo.STAT6 deficiency ameliorates Graves' disease severity by suppressing thyroid epithelial cell hyperplasiaCross talk between focal adhesion kinase and cadherins: role in regulating endothelial barrier function.Role of ion transport in control of apoptotic cell death.Targeting FAK in human cancer: from finding to first clinical trials.Microvesicle Cargo and Function Changes upon Induction of Cellular Transformation.Phosphotyrosine enrichment identifies focal adhesion kinase and other tyrosine kinases for targeting in canine hemangiosarcoma.The role of focal adhesion kinase catalytic activity on the proliferation and migration of squamous cell carcinoma cells.Targeting vascular endothelial growth factor receptor-1 and -3 with cediranib (AZD2171): effects on migration and invasion of gastrointestinal cancer cell lines.VEGF-D is expressed in activated lymphoid cells and in tumors of hematopoietic and lymphoid tissues.Preferential phosphorylation of focal adhesion kinase tyrosine 861 is critical for mediating an anti-apoptotic response to hyperosmotic stress.Overexpression of focal adhesion kinase correlates with increased lymph node metastasis and poor prognosis in non-small-cell lung cancer.Targeting Focal Adhesion Kinase Using Inhibitors of Protein-Protein Interactions
P2860
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P2860
Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells.
description
2006 nî lūn-bûn
@nan
2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Vascular endothelial growth fa ...... ptosis in breast cancer cells.
@ast
Vascular endothelial growth fa ...... ptosis in breast cancer cells.
@en
type
label
Vascular endothelial growth fa ...... ptosis in breast cancer cells.
@ast
Vascular endothelial growth fa ...... ptosis in breast cancer cells.
@en
prefLabel
Vascular endothelial growth fa ...... ptosis in breast cancer cells.
@ast
Vascular endothelial growth fa ...... ptosis in breast cancer cells.
@en
P2093
P1433
P1476
Vascular endothelial growth fa ...... ptosis in breast cancer cells.
@en
P2093
Christopher A Garces
Elena V Kurenova
Vita M Golubovskaya
William G Cance
P304
P356
10.1158/0008-5472.CAN-05-1661
P407
P577
2006-02-01T00:00:00Z