A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation.
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The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic inventionThe CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradationSuppression of cancer cell growth by promoting cyclin D1 degradationF-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damageNIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressorA novel role of IKKalpha in the mediation of UVB-induced G0/G1 cell cycle arrest response by suppressing Cyclin D1 expressionControl of cell growth by the SCF and APC/C ubiquitin ligasesInhibition of NEDD8-conjugation pathway by novel molecules: potential approaches to anticancer therapyGenetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligasesThe role of aberrant proteolysis in lymphomagenesisF-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferationFBXL2 is a ubiquitin E3 ligase subunit that triggers mitotic arrestF-box protein FBXL2 exerts human lung tumor suppressor-like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrestInhibition of chemokine (C-C motif) receptor 7 sialylation suppresses CCL19-stimulated proliferation, invasion and anti-anoikisDeregulation of F-box proteins and its consequence on cancer development, progression and metastasis.MEK2 is a prognostic marker and potential chemo-sensitizing target for glioma patients undergoing temozolomide treatment.alphaB-crystallin is mutant B-RAF regulated and contributes to cyclin D1 turnover in melanocytic cells.Anti-inflammatory and anti-cancer activity of mulberry (Morus alba L.) root barkF-box proteins FBXO31 and FBX4 in regulation of cyclin D1 degradation upon DNA damage.Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation.Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases.Ubiquitin-dependent proteolysis in G1/S phase control and its relationship with tumor susceptibilityp14ARF post-transcriptional regulation of nuclear cyclin D1 in MCF-7 breast cancer cells: discrimination between a good and bad prognosis?Merkel cell polyomavirus small T antigen controls viral replication and oncoprotein expression by targeting the cellular ubiquitin ligase SCFFbw7.Identification of molecular pathway aberrations in uterine serous carcinoma by genome-wide analyses.Ubiquitination and degradation of the hominoid-specific oncoprotein TBC1D3 is mediated by CUL7 E3 ligaseInteraction and co-localization of JC virus large T antigen and the F-box protein β-transducin-repeat containing protein.Expression of a transgene encoding mutant p193/CUL7 preserves cardiac function and limits infarct expansion after myocardial infarctionTerpenic fraction of Pterodon pubescens inhibits nuclear factor kappa B and extracellular signal-regulated protein kinase 1/2 activation and deregulates gene expression in leukemia cells.Characterization of growth suppressive functions of a splice variant of cyclin D2.Cellular transformation by Simian Virus 40 and Murine Polyoma Virus T antigens.Roles of F-box proteins in cancerOphiobolin O isolated from Aspergillus ustus induces G1 arrest of MCF-7 cells through interaction with AKT/GSK3β/cyclin D1 signalingIdentifying biological pathways that underlie primordial short stature using network analysis.Genetic reevaluation of the role of F-box proteins in cyclin D1 degradation.SCF ubiquitin ligases in the maintenance of genome stability.Anti-Proliferative Effect of Naringenin through p38-Dependent Downregulation of Cyclin D1 in Human Colorectal Cancer CellsF-box protein specificity for g1 cyclins is dictated by subcellular localization.Anti-cancer activity of Psoralea fructus through the downregulation of cyclin D1 and CDK4 in human colorectal cancer cells.
P2860
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P2860
A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation.
description
2006 nî lūn-bûn
@nan
2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
A critical role for FBXW8 and ...... and cancer cell proliferation.
@ast
A critical role for FBXW8 and ...... and cancer cell proliferation.
@en
type
label
A critical role for FBXW8 and ...... and cancer cell proliferation.
@ast
A critical role for FBXW8 and ...... and cancer cell proliferation.
@en
prefLabel
A critical role for FBXW8 and ...... and cancer cell proliferation.
@ast
A critical role for FBXW8 and ...... and cancer cell proliferation.
@en
P2093
P2860
P1433
P1476
A critical role for FBXW8 and ...... and cancer cell proliferation.
@en
P2093
Donna G Albertson
Frank McCormick
Hiroshi Okabe
Janyaporn Phuchareon
Sang-Hyun Lee
P2860
P356
10.1371/JOURNAL.PONE.0000128
P407
P50
P577
2006-12-27T00:00:00Z