Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cells.
about
In situ quantification of HER2-protein tyrosine kinase 6 (PTK6) protein-protein complexes in paraffin sections from breast cancer tissuesThe unique N-terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate docking protein 1Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6MEK5/ERK5 pathway: the first fifteen yearsProtein-tyrosine kinase 6 promotes peripheral adhesion complex formation and cell migration by phosphorylating p130 CRK-associated substrateProtein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factorBrk is coamplified with ErbB2 to promote proliferation in breast cancerBrk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4Cancer-Associated Mutations in Breast Tumor Kinase/PTK6 Differentially Affect Enzyme Activity and Substrate Recognition.Low expression of PTK6/Brk predicts poor prognosis in patients with laryngeal squamous cell carcinoma.The alternative splice variant of protein tyrosine kinase 6 negatively regulates growth and enhances PTK6-mediated inhibition of β-cateninComputational analysis of biological functions and pathways collectively targeted by co-expressed microRNAs in cancer.Protein kinases mediate ligand-independent derepression of sumoylated progesterone receptors in breast cancer cells.The marine-derived sipholenol A-4-O-3',4'-dichlorobenzoate inhibits breast cancer growth and motility in vitro and in vivo through the suppression of Brk and FAK signaling.PTK6 regulates IGF-1-induced anchorage-independent survival.Brk/PTK6 signaling in normal and cancer cell models.A chemical and phosphoproteomic characterization of dasatinib action in lung cancerBuilding a better understanding of the intracellular tyrosine kinase PTK6 - BRK by BRKEvolution of breast cancer therapeutics: Breast tumour kinase's role in breast cancer and hope for breast tumour kinase targeted therapyHIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion.Mechanisms of HGF/Met signaling to Brk and Sam68 in breast cancer progression.Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells.Expression of the phosphorylated MEK5 protein is associated with TNM staging of colorectal cancer.PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumors.Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells.The role of master regulators in the metabolic/transcriptional coupling in breast carcinomasRAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRK.Cytoplasmic retention of protein tyrosine kinase 6 promotes growth of prostate tumor cells.Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression.G-Protein Inwardly Rectifying Potassium Channel 1 (GIRK1) Knockdown Decreases Beta-Adrenergic, MAP Kinase and Akt Signaling in the MDA-MB-453 Breast Cancer Cell Line.BRK targets Dok1 for ubiquitin-mediated proteasomal degradation to promote cell proliferation and migration.Sphingosine-1-phosphate induces the migration of thyroid follicular carcinoma cells through the microRNA-17/PTK6/ERK1/2 pathwayPTK6 promotes cancer migration and invasion in pancreatic cancer cells dependent on ERK signaling.Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK.PTK6 inhibition promotes apoptosis of Lapatinib-resistant Her2(+) breast cancer cells by inducing Bim.Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFRProtein tyrosine kinase 6 promotes ERBB2-induced mammary gland tumorigenesis in the mouse.Suppressor of cytokine signaling 3 inhibits breast tumor kinase activation of STAT3.Constitutive activation of breast tumor kinase accelerates cell migration and tumor growth in vivo.PYK2 integrates growth factor and cytokine receptors signaling and potentiates breast cancer invasion via a positive feedback loop.
P2860
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P2860
Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cells.
description
2007 nî lūn-bûn
@nan
2007 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Breast tumor kinase (protein t ...... inases in breast cancer cells.
@ast
Breast tumor kinase (protein t ...... inases in breast cancer cells.
@en
type
label
Breast tumor kinase (protein t ...... inases in breast cancer cells.
@ast
Breast tumor kinase (protein t ...... inases in breast cancer cells.
@en
prefLabel
Breast tumor kinase (protein t ...... inases in breast cancer cells.
@ast
Breast tumor kinase (protein t ...... inases in breast cancer cells.
@en
P2093
P1433
P1476
Breast tumor kinase (protein t ...... inases in breast cancer cells.
@en
P2093
Andrea R Daniel
Carol A Lange
Celina G Kleer
Julie Hanson Ostrander
Kristopher Lofgren
P304
P356
10.1158/0008-5472.CAN-06-3409
P407
P577
2007-05-01T00:00:00Z