PTK6 regulates IGF-1-induced anchorage-independent survival. - Wikidata - wikimedia - TriplyDB

PTK6 regulates IGF-1-induced anchorage-independent survival.

PTK6 regulates IGF-1-induced anchorage-independent survival.

http://www.wikidata.org/entity/Q33644326

about

Protein-tyrosine kinase 6 promotes peripheral adhesion complex formation and cell migration by phosphorylating p130 CRK-associated substrate Cancer-Associated Mutations in Breast Tumor Kinase/PTK6 Differentially Affect Enzyme Activity and Substrate Recognition.The alternative splice variant of protein tyrosine kinase 6 negatively regulates growth and enhances PTK6-mediated inhibition of β-catenin Evolution of breast cancer therapeutics: Breast tumour kinase's role in breast cancer and hope for breast tumour kinase targeted therapy HIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion.PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumors.Cytoplasmic retention of protein tyrosine kinase 6 promotes growth of prostate tumor cells.Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression.PTK6 promotes cancer migration and invasion in pancreatic cancer cells dependent on ERK signaling.PTK6 inhibition promotes apoptosis of Lapatinib-resistant Her2(+) breast cancer cells by inducing Bim.Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR Protein tyrosine kinase 6 promotes ERBB2-induced mammary gland tumorigenesis in the mouse.Insulin-like growth factors are essential to prevent anoikis in oestrogen-responsive breast cancer cells: importance of the type I IGF receptor and PI3-kinase/Akt pathway Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer Protein-tyrosine phosphatase 1B antagonized signaling by insulin-like growth factor-1 receptor and kinase BRK/PTK6 in ovarian cancer cells.PRKCQ promotes oncogenic growth and anoikis resistance of a subset of triple-negative breast cancer cells.Protein tyrosine kinase 6 regulates mammary gland tumorigenesis in mouse models.Context-specific protein tyrosine kinase 6 (PTK6) signalling in prostate cancer.Cell-based assays for IGF-I bioactivity measurement: overview, limitations and current trends.The marine-derived pachycladin diterpenoids as novel inhibitors of wild-type and mutant EGFR.PTK6 promotes hepatocellular carcinoma cell proliferation and invasion.Additive impact of HER2-/PTK6-RNAi on interactions with HER3 or IGF-1R leads to reduced breast cancer progression in vivo.RSK promotes prostate cancer progression in bone through ING3, CKAP2, and PTK6-mediated cell survival PTK6 activation at the membrane regulates epithelial-mesenchymal transition in prostate cancer.p90 RSK2 mediates antianoikis signals by both transcription-dependent and -independent mechanisms.Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT.Disruption of the mouse protein tyrosine kinase 6 gene prevents STAT3 activation and confers resistance to azoxymethane.Role of Insulin-like Growth Factor, Insulin-like Growth Factor Receptors, and Insulin-like Growth Factor-binding Proteins in Ovarian Cancer.Targeting protein tyrosine kinase 6 enhances apoptosis of colon cancer cells following DNA damage.PTK6 regulates growth and survival of endocrine therapy-resistant ER+ breast cancer cells.PTK6 Localized at the Plasma Membrane Promotes Cell Proliferation and MigratiOn Through Phosphorylation of Eps8.Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers.Overexpression of IRS-4 Correlates with Procaspase 3 Levels in Tumoural Tissue of Patients with Colorectal Cancer

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PTK6 regulates IGF-1-induced anchorage-independent survival.

http://www.wikidata.org/entity/Q33644326

description

2010 nî lūn-bûn

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2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

@zh-hk

2010年論文

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2010年論文

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2010年论文

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name

PTK6 regulates IGF-1-induced anchorage-independent survival.

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PTK6 regulates IGF-1-induced anchorage-independent survival.

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type

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PTK6 regulates IGF-1-induced anchorage-independent survival.

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PTK6 regulates IGF-1-induced anchorage-independent survival.

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prefLabel

PTK6 regulates IGF-1-induced anchorage-independent survival.

@ast

PTK6 regulates IGF-1-induced anchorage-independent survival.

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JOURNAL.PONE.0011729

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P1476

PTK6 regulates IGF-1-induced anchorage-independent survival.

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P2093

Andrea L Richardson

http://www.w3.org/2001/XMLSchema#string

Charles B Epstein

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Fabianne Frye

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Gordon B Mills

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Hanna Y Irie

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Joan S Brugge

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Jun Yao

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Kornelia Polyak

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Laura M Selfors

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Lihua Zou

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P2860

Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6

Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours

Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes

Gene expression profiling predicts clinical outcome of breast cancer

Brk is coamplified with ErbB2 to promote proliferation in breast cancer

Repeated observation of breast tumor subtypes in independent gene expression data sets

Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation

Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells

Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases

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e11729

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scholarly article

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10.1371/JOURNAL.PONE.0011729

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7

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2010-07-23T00:00:00Z

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45406903

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20668531

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2909213

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