Mutational analysis of EGFR and related signaling pathway genes in lung adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4 - Wikidata - wikimedia - TriplyDB

Mutational analysis of EGFR and related signaling pathway genes in lung adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4

Mutational analysis of EGFR and related signaling pathway genes in lung adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4

http://www.wikidata.org/entity/Q33283995

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Somatic mutations affect key pathways in lung adenocarcinoma Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers MYC is a metastasis gene for non-small-cell lung cancer Polycomb group protein Bmi1 is required for growth of RAF driven non-small-cell lung cancer Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models.Combined Inactivation of MYC and K-Ras oncogenes reverses tumorigenesis in lung adenocarcinomas and lymphomas.Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines.Cancer genomics identifies regulatory gene networks associated with the transition from dysplasia to advanced lung adenocarcinomas induced by c-Raf-1.Is fibroblast growth factor receptor 4 a suitable target of cancer therapy?Detection of somatic mutations by high-resolution DNA melting (HRM) analysis in multiple cancers.PIK3CA mutations and copy number gains in human lung cancers.Genomic and mutational profiling to assess clonal relationships between multiple non-small cell lung cancers.Signaling networks associated with AKT activation in non-small cell lung cancer (NSCLC): new insights on the role of phosphatydil-inositol-3 kinase.Oncogenic function of SCCRO5/DCUN1D5 requires its Neddylation E3 activity and nuclear localization.The FGF/FGFR axis as a therapeutic target in breast cancer.Multiple genetic alterations within the PI3K pathway are responsible for AKT activation in patients with ovarian carcinoma Roles of EGFR and KRAS Mutations in the Treatment Of Patients With Non-Small-Cell Lung Cancer.FGFR4 and its novel splice form in myogenic cells: Interplay of glycosylation and tyrosine phosphorylation.A growing family: adding mutated Erbb4 as a novel cancer target Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.Clinical Significance of ErbB Receptor Family in Urothelial Carcinoma of the Bladder: A Systematic Review and Meta-Analysis High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia.Drug-sensitive FGFR2 mutations in endometrial carcinoma Thymic neoplasm: a rare disease with a complex clinical presentation Identification of a novel HER3 activating mutation homologous to EGFR-L858R in lung cancer.Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma Acquired resistance to epidermal growth factor receptor kinase inhibitors associated with a novel T854A mutation in a patient with EGFR-mutant lung adenocarcinoma High-content analysis of cancer genome DNA alterations.Lung adenocarcinoma: guiding EGFR-targeted therapy and beyond.An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors Analytical methods for inferring functional effects of single base pair substitutions in human cancers.Theme: oncology--molecular mechanisms determining the efficacy of EGF receptor-specific tyrosine kinase inhibitors help to identify biomarker candidates.Fibroblast growth factors and their receptors in cancer.The liquid biopsy in lung cancer Expression level of CRKL and AXL combined with exon 19 deletion in EGFR and ALK status confer differential prognosis of lung adenocarcinoma subtypes.Conditional expression of oncogenic C-RAF in mouse pulmonary epithelial cells reveals differential tumorigenesis and induction of autophagy leading to tumor regression.Lung cancers unrelated to smoking: characterized by single oncogene addiction?Resident hepatocyte fibroblast growth factor receptor 4 limits hepatocarcinogenesis.The genomics of lung adenocarcinoma: opportunities for targeted therapies.New lung cancer panel for high-throughput targeted resequencing.

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Mutational analysis of EGFR and related signaling pathway genes in lung adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4

http://www.wikidata.org/entity/Q33283995

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2007 nî lūn-bûn

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Mutational analysis of EGFR an ...... inase domain mutation in FGFR4

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Mutational analysis of EGFR an ...... inase domain mutation in FGFR4

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Mutational analysis of EGFR an ...... inase domain mutation in FGFR4

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Mutational analysis of EGFR an ...... inase domain mutation in FGFR4

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Mutational analysis of EGFR an ...... inase domain mutation in FGFR4

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Mutational analysis of EGFR an ...... inase domain mutation in FGFR4

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Bhuvanesh Singh

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Duykhanh Pham

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Elaine R Mardis

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Ginger A Fewell

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Inderpal S Sarkaria

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Jenifer L Marks

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Lucinda L Fulton

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Michael D McLellan

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Richard K Wilson

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P2860

KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib

Cellular signaling by fibroblast growth factor receptors

EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib

Multiple sequence alignment with the Clustal series of programs

CDD: a conserved domain database for interactive domain family analysis

Entrez Gene: gene-centered information at NCBI

Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain

Database resources of the National Center for Biotechnology Information

Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism

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Harold E. Varmus

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