A novel site of AKT-mediated phosphorylation in the human MDM2 onco-protein.
about
Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2--Potential interplay with the PKB/Akt pathway and p14(ARF)Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnoverPhysiological regulation of Akt activity and stability.Mdm2 links genotoxic stress and metabolism to p53.Detection of functional single-nucleotide polymorphisms that affect apoptosisActivation of murine double minute 2 by Akt in mammary epithelium delays mammary involution and accelerates mammary tumorigenesis.Differential regulation of androgen receptor by PIM-1 kinases via phosphorylation-dependent recruitment of distinct ubiquitin E3 ligases.Mdm2 in growth signaling and cancer.The Roles of MDM2 and MDMX Phosphorylation in Stress Signaling to p53.Role of the phosphatidylinositol-3-kinase and extracellular regulated kinase pathways in the induction of hypoxia-inducible factor (HIF)-1 activity and the HIF-1 target vascular endothelial growth factor in ovarian granulosa cells in response to folLoss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6.Akt promotes chemoresistance in human ovarian cancer cells by modulating cisplatin-induced, p53-dependent ubiquitination of FLICE-like inhibitory protein.New p53 target, phosphatase of regenerating liver 1 (PRL-1) downregulates p53.Elevated levels of oncogenic protein kinase Pim-1 induce the p53 pathway in cultured cells and correlate with increased Mdm2 in mantle cell lymphoma.AKT1 E17K mutant phosphorylates MDM2AKT phosphorylates MDM2The PI3K/AKT/mTOR interactive pathway.HER-2 positive and p53 negative breast cancers are associated with poor prognosis.
P2860
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P2860
A novel site of AKT-mediated phosphorylation in the human MDM2 onco-protein.
description
2004 nî lūn-bûn
@nan
2004 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
A novel site of AKT-mediated phosphorylation in the human MDM2 onco-protein.
@ast
A novel site of AKT-mediated phosphorylation in the human MDM2 onco-protein.
@en
type
label
A novel site of AKT-mediated phosphorylation in the human MDM2 onco-protein.
@ast
A novel site of AKT-mediated phosphorylation in the human MDM2 onco-protein.
@en
prefLabel
A novel site of AKT-mediated phosphorylation in the human MDM2 onco-protein.
@ast
A novel site of AKT-mediated phosphorylation in the human MDM2 onco-protein.
@en
P2093
P2860
P1433
P1476
A novel site of AKT-mediated phosphorylation in the human MDM2 onco-protein.
@en
P2093
David G Campbell
David Meek
Diane Milne
Frances Fuller-Pace
Petros Kampanis
Samantha Nicol
Sylvia Dias
P2860
P304
P356
10.1016/J.FEBSLET.2004.09.081
P407
P577
2004-11-01T00:00:00Z