Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease. - Wikidata - wikimedia - TriplyDB

Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease.

Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease.

http://www.wikidata.org/entity/Q33292417

about

Amyloid-mediated sequestration of essential proteins contributes to mutant huntingtin toxicity in yeast Huntingtin interacting proteins are genetic modifiers of neurodegeneration Novel nuclear shuttle proteins, HDBP1 and HDBP2, bind to neuronal cell-specific cis-regulatory element in the promoter for the human Huntington's disease gene ZBP-89 represses vimentin gene transcription by interacting with the transcriptional activator, Sp1 Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model.Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series Multiple Aspects of Gene Dysregulation in Huntington's Disease Congenital hydrocephalus associated with abnormal subcommissural organ in mice lacking huntingtin in Wnt1 cell lineages Improved activities of CREB binding protein, heterogeneous nuclear ribonucleoproteins and proteasome following downregulation of noncoding hsromega transcripts help suppress poly(Q) pathogenesis in fly models The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice.Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2 Conserved and specific functions of mammalian ssu72 Transgenic animal models for study of the pathogenesis of Huntington's disease and therapy Hydrogen peroxide sensing, signaling and regulation of transcription factors Therapeutic Approaches for Inhibition of Protein Aggregation in Huntington's Disease Huntington's disease: underlying molecular mechanisms and emerging concepts Transcriptional dysregulation in Huntington's disease: a failure of adaptive transcriptional homeostasis EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques Huntingtin's function in axonal transport is conserved in Drosophila melanogaster The structure of a polyQ-anti-polyQ complex reveals binding according to a linear lattice model Conserved region I of human coactivator TAF4 binds to a short hydrophobic motif present in transcriptional regulators Yeast TFIID serves as a coactivator for Rap1p by direct protein-protein interaction Transglutaminase 2 has opposing roles in the regulation of cellular functions as well as cell growth and death The Role of the Ubiquitously Expressed Transcription Factor Sp1 in Tissue-specific Transcriptional Regulation and in Disease The promise and perils of HDAC inhibitors in neurodegeneration Expression of mutant huntingtin blocks exocytosis in PC12 cells by depletion of complexin II Molecular mechanism of monoamine oxidase A gene regulation under inflammation and ischemia-like conditions: key roles of the transcription factors GATA2, Sp1 and TBP Huntingtin and its role in neuronal degeneration Glutamate receptor activation evokes calpain-mediated degradation of Sp3 and Sp4, the prominent Sp-family transcription factors in neurons Differential repression by freud-1/CC2D1A at a polymorphic site in the dopamine-D2 receptor gene Modes of physiologic H2S signaling in the brain and peripheral tissues Homeostatic adaptations in brain energy metabolism in mouse models of Huntington disease Functional roles for the striatal-enriched transcription factor, Bcl11b, in the control of striatal gene expression and transcriptional dysregulation in Huntington's disease Functional analysis of the rat N-methyl-D-aspartate receptor 2A promoter: multiple transcription starts points, positive regulation by Sp factors, and translational regulation The epigenetic effect of nicotine on dopamine D1 receptor expression in rat prefrontal cortex Mitochondrial transcription factor A and its downstream targets are up-regulated in a rat hepatoma Cystatin B deficiency sensitizes neurons to oxidative stress in progressive myoclonus epilepsy, EPM1 Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro Altered aggregation properties of mutant gamma-crystallins cause inherited cataract Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity

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P2860

Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease.

http://www.wikidata.org/entity/Q33292417

description

2002 nî lūn-bûn

@nan

2002 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2002年の論文

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2002年論文

@yue

2002年論文

@zh-hant

2002年論文

@zh-hk

2002年論文

@zh-mo

2002年論文

@zh-tw

2002年论文

@wuu

name

Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease.

@ast

Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease.

@en

type

label

Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease.

@ast

Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease.

@en

prefLabel

Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease.

@ast

Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease.

@en

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SCIENCE.1072613

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P1476

Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease.

@en

P2093

Anne B Young

http://www.w3.org/2001/XMLSchema#string

Anthone W Dunah

http://www.w3.org/2001/XMLSchema#string

April Griffin

http://www.w3.org/2001/XMLSchema#string

Dimitri Krainc

http://www.w3.org/2001/XMLSchema#string

Hyunkyung Jeong

http://www.w3.org/2001/XMLSchema#string

M Maral Mouradian

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Yong-Man Kim

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2238-2243

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scholarly article

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10.1126/SCIENCE.1072613

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5576

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296

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David G. Standaert

Steven M Hersch

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2002-05-02T00:00:00Z

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11380844

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11988536

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Huntington disease