Huntingtin interacting proteins are genetic modifiers of neurodegeneration
about
Identification of human proteins that modify misfolding and proteotoxicity of pathogenic ataxin-1Oligonucleotide therapeutic approaches for Huntington diseaseEarly alterations of brain cellular energy homeostasis in Huntington disease modelsThe palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's diseaseA protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal componentsHeterodimerization of Lrrk1-Lrrk2: Implications for LRRK2-associated Parkinson diseaseGenome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WACDevelopment and application of a DNA microarray-based yeast two-hybrid systemSCAMP5 links endoplasmic reticulum stress to the accumulation of expanded polyglutamine protein aggregates via endocytosis inhibitionpARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular traffickingMutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's diseaseGabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesisAnimal models of polyglutamine diseases and therapeutic approachesEpigenetic principles and mechanisms underlying nervous system functions in health and diseaseModel systems of protein-misfolding diseases reveal chaperone modifiers of proteotoxicityStructure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive reviewLa FAM fatale: USP9X in development and diseaseGenetic modifiers of MeCP2 function in Drosophila.dAtaxin-2 mediates expanded Ataxin-1-induced neurodegeneration in a Drosophila model of SCA1Huntingtin's function in axonal transport is conserved in Drosophila melanogasterSIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesisA novel multiplex cell viability assay for high-throughput RNAi screeningNanopublications for exposing experimental data in the life-sciences: a Huntington's Disease case studyIn silico discovery and experimental validation of new protein-protein interactionsNeuronal Mitophagy in Neurodegenerative DiseasesIs Huntingtin Dispensable in the Adult Brain?Huntingtin is required for normal excitatory synapse development in cortical and striatal circuitsProteomic analysis of wild-type and mutant huntingtin-associated proteins in mouse brains identifies unique interactions and involvement in protein synthesis.Multiple phenotypes in Huntington disease mouse neural stem cells.Trinucleotide repeats: a structural perspectiveSynaptic mutant huntingtin inhibits synapsin-1 phosphorylation and causes neurological symptoms.Elucidating a normal function of huntingtin by functional and microarray analysis of huntingtin-null mouse embryonic fibroblasts.The Huntington disease protein accelerates breast tumour development and metastasis through ErbB2/HER2 signalling.Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's diseasePolyglutamine toxicity in yeast induces metabolic alterations and mitochondrial defectsA human protein interaction network shows conservation of aging processes between human and invertebrate species.F-actin binding regions on the androgen receptor and huntingtin increase aggregation and alter aggregate characteristicsPolyglutamine-rich suppressors of huntingtin toxicity act upstream of Hsp70 and Sti1 in spatial quality control of amyloid-like proteins.Role for protein-protein interaction databases in human genetics.Pharmacology of epigenetics in brain disorders
P2860
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
P248
Q21144909-FB14BD84-A857-4717-AFFC-8763DA53FD05Q22306293-6585E1CC-86F2-4A7F-9DBE-8EF663DBDBB6Q23912810-3E870D13-E319-4140-A775-D99CC011AE1FQ24293871-23EC4C92-5362-44B7-B29A-EA875C990921Q24294383-641C33A4-C522-441D-858D-3F0FDA41D2A1Q24298781-105D5130-6C1D-4492-BAA6-38CC23793DFAQ24305544-0069D4A7-47E9-4574-B5EA-0F52BDDD6C43Q24307459-C159665E-E637-4DB9-A1F7-67A5F7002F99Q24314585-D191038C-EE39-43B4-BFBA-CC8FC6011B63Q24316303-B0433193-86B9-4147-B50B-D54DF593B8F5Q24317702-AE0A1DF9-8F1A-4918-9379-19C68EB6E043Q24323318-AED6CF8D-AAA3-4C65-8E51-05DE263208F5Q24655528-9FAFFF7F-DFF0-4E43-89C6-C92C1624E56DQ24657549-84B1B570-6835-4845-AA5B-BF1BD4008D68Q26739032-A226CD29-DC34-4E5D-AF04-B627F3F2889DQ27008867-5AA24BC2-A438-4E96-A214-D2C4B6BA9060Q27025293-1288BB59-01A8-485B-81C0-AAE1DD584801Q27313791-D711A1FA-267D-471D-B4E7-281CC9325FC7Q27314605-897AB8EF-90AB-4373-A048-9995D0015B33Q27331461-CD2CB719-01E8-4C9B-841A-6A734EA04F1EQ28279273-151AEA31-0D58-4ADB-9441-229965181BE5Q28478264-8893909F-D9B2-4096-9799-B204A4B07F01Q28606409-DA0212E6-08A2-41DF-B536-49470B24E09DQ28842760-F645D9BC-0A50-4A4D-9B24-06CA6EF0E428Q29248361-2990EC7A-C0A7-41ED-93B5-0C06378CA179Q30353134-70D65656-9718-4610-A242-D9CBF206219EQ30408636-CC1A679A-1B2D-45E1-BB5B-8F0D55D48DACQ30418699-A4F43DE4-5757-40E3-9FF5-46F8D046977CQ30419653-0AF57115-D8FE-4726-8319-E25DB7FA7B32Q30432441-369EDD47-3A18-4907-8D53-0B9D372045F6Q30441124-5D65742C-ACC5-4230-B615-AD51CA64CFEDQ30441792-6ACD3B2D-27CC-4DBE-8082-E1DC03B5B8EAQ30535295-0E9E7C90-A91B-49D0-B054-3856BF3905DCQ30581321-9AD85D17-2C6F-4F2D-9FBB-EFD7959EBB30Q30663550-E4FF59A0-2F45-4D25-B0B5-5F70334D3814Q33419100-96483408-F6A4-4B7E-8452-93D6692C0EE5Q33530121-60C61605-5356-4929-9E23-8F9111637AEDQ33609884-89B4703B-0D10-4B28-992D-429B33FCBC6FQ33619990-E3EFD3ED-AD90-4285-8E2D-40AC85772374Q33673025-5417942C-B382-4BBF-A64D-CD5F420A19E9
P2860
Huntingtin interacting proteins are genetic modifiers of neurodegeneration
description
2007 nî lūn-bûn
@nan
2007 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Huntingtin interacting proteins are genetic modifiers of neurodegeneration
@ast
Huntingtin interacting proteins are genetic modifiers of neurodegeneration
@en
Huntingtin interacting proteins are genetic modifiers of neurodegeneration
@en-gb
Huntingtin interacting proteins are genetic modifiers of neurodegeneration
@nl
type
label
Huntingtin interacting proteins are genetic modifiers of neurodegeneration
@ast
Huntingtin interacting proteins are genetic modifiers of neurodegeneration
@en
Huntingtin interacting proteins are genetic modifiers of neurodegeneration
@en-gb
Huntingtin interacting proteins are genetic modifiers of neurodegeneration
@nl
prefLabel
Huntingtin interacting proteins are genetic modifiers of neurodegeneration
@ast
Huntingtin interacting proteins are genetic modifiers of neurodegeneration
@en
Huntingtin interacting proteins are genetic modifiers of neurodegeneration
@en-gb
Huntingtin interacting proteins are genetic modifiers of neurodegeneration
@nl
P2093
P2860
P921
P3181
P1433
P1476
Huntingtin interacting proteins are genetic modifiers of neurodegeneration
@en
P2093
Amit Phansalkar
Andrew Strand
Anthony Hurlburt
Cameron Torcassi
Cindy Lou Chepanoske
Cornelia Kurschner
Eliana Romero
Guang-Ho Cha
James Olson
John M Peltier
P2860
P3181
P356
10.1371/JOURNAL.PGEN.0030082
P407
P577
2007-05-11T00:00:00Z