The extended cleavage specificity of the rodent beta-chymases rMCP-1 and mMCP-4 reveal major functional similarities to the human mast cell chymase.
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Guinea pig chymase is leucine-specific: a novel example of functional plasticity in the chymase/granzyme family of serine peptidasesThe extended substrate specificity of the human mast cell chymase reveals a serine protease with well-defined substrate recognition profile.Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase/Mcpt4-dependent mechanism.Arg143 and Lys192 of the human mast cell chymase mediate the preference for acidic amino acids in position P2' of substrates.Development of mast cells and importance of their tryptase and chymase serine proteases in inflammation and wound healing.The extended cleavage specificity of human thrombin.Pivotal role of mouse mast cell protease 4 in the conversion and pressor properties of Big-endothelin-1.The inflammatory response after an epidermal burn depends on the activities of mouse mast cell proteases 4 and 5.Mutations in Arg143 and Lys192 of the Human Mast Cell Chymase Markedly Affect the Activity of Five Potent Human Chymase Inhibitors.Generation of a new congenic mouse strain with enhanced chymase expression in mast cells.Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in miceDual targets for mouse mast cell protease-4 in mediating tissue damage in experimental bullous pemphigoidrMCP-2, the Major Rat Mucosal Mast Cell Protease, an Analysis of Its Extended Cleavage Specificity and Its Potential Role in Regulating Intestinal Permeability by the Cleavage of Cell Adhesion and Junction ProteinsGranule Associated Serine Proteases of Hematopoietic Cells - An Analysis of Their Appearance and Diversification during Vertebrate Evolution.Asp-ase Activity of the Opossum Granzyme B Supports the Role of Granzyme B as Part of Anti-Viral Immunity Already during Early Mammalian Evolution.Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune EncephalomyelitisThe chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis.Potential effector and immunoregulatory functions of mast cells in mucosal immunity.Chymase-mediated intestinal epithelial permeability is regulated by a protease-activating receptor/matrix metalloproteinase-2-dependent mechanism.IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction.Mast cell chymase degrades the alarmins heat shock protein 70, biglycan, HMGB1, and interleukin-33 (IL-33) and limits danger-induced inflammationChymase inhibition as a pharmacological target: a role in inflammatory and functional gastrointestinal disorders?The anti-allergic compound tranilast attenuates inflammation and inhibits bone destruction in collagen-induced arthritis in mice.The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells.Extended cleavage specificity of the mast cell chymase from the crab-eating macaque (Macaca fascicularis): an interesting animal model for the analysis of the function of the human mast cell chymase.Evolutionary relationships between seryl-histidine dipeptide and modern serine proteases from the analysis based on mass spectrometry and bioinformatics.Highly Selective Cleavage of Cytokines and Chemokines by the Human Mast Cell Chymase and Neutrophil Cathepsin G.Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation.Extended cleavage specificity of human neutrophil cathepsin G: A low activity protease with dual chymase and tryptase-type specificities.The Autoimmune Skin Disease Bullous Pemphigoid: The Role of Mast Cells in Autoantibody-Induced Tissue Injury.Extended Cleavage Specificity of Human Neutrophil Elastase, Human Proteinase 3, and Their Distant Ortholog Clawed Frog PR3-Three Elastases With Similar Primary but Different Extended Specificities and Stability
P2860
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P2860
The extended cleavage specificity of the rodent beta-chymases rMCP-1 and mMCP-4 reveal major functional similarities to the human mast cell chymase.
description
2007 nî lūn-bûn
@nan
2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
name
The extended cleavage specific ...... o the human mast cell chymase.
@ast
The extended cleavage specific ...... o the human mast cell chymase.
@en
The extended cleavage specific ...... o the human mast cell chymase.
@nl
type
label
The extended cleavage specific ...... o the human mast cell chymase.
@ast
The extended cleavage specific ...... o the human mast cell chymase.
@en
The extended cleavage specific ...... o the human mast cell chymase.
@nl
prefLabel
The extended cleavage specific ...... o the human mast cell chymase.
@ast
The extended cleavage specific ...... o the human mast cell chymase.
@en
The extended cleavage specific ...... o the human mast cell chymase.
@nl
P2093
P1433
P1476
The extended cleavage specific ...... o the human mast cell chymase.
@en
P2093
Lars Hellman
Mattias K Andersson
Ulrika Karlson
P304
P356
10.1016/J.MOLIMM.2007.06.360
P577
2007-08-06T00:00:00Z