The extended substrate specificity of the human mast cell chymase reveals a serine protease with well-defined substrate recognition profile.
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A tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregationArg143 and Lys192 of the human mast cell chymase mediate the preference for acidic amino acids in position P2' of substrates.The extended cleavage specificity of human thrombin.Mast cell proteases as pharmacological targetsMutations in Arg143 and Lys192 of the Human Mast Cell Chymase Markedly Affect the Activity of Five Potent Human Chymase Inhibitors.Generation of a new congenic mouse strain with enhanced chymase expression in mast cells.rMCP-2, the Major Rat Mucosal Mast Cell Protease, an Analysis of Its Extended Cleavage Specificity and Its Potential Role in Regulating Intestinal Permeability by the Cleavage of Cell Adhesion and Junction ProteinsGranule Associated Serine Proteases of Hematopoietic Cells - An Analysis of Their Appearance and Diversification during Vertebrate Evolution.Chymase-mediated intestinal epithelial permeability is regulated by a protease-activating receptor/matrix metalloproteinase-2-dependent mechanism.Mast cell chymase degrades the alarmins heat shock protein 70, biglycan, HMGB1, and interleukin-33 (IL-33) and limits danger-induced inflammationMast cell chymase and tryptase as targets for cardiovascular and metabolic diseases.Chymase inhibition as a pharmacological target: a role in inflammatory and functional gastrointestinal disorders?Discriminating between the activities of human cathepsin G and chymase using fluorogenic substrates.Extended cleavage specificity of the mast cell chymase from the crab-eating macaque (Macaca fascicularis): an interesting animal model for the analysis of the function of the human mast cell chymase.Expression of recombinant human mast cell chymase with Asn-linked glycans in glycoengineered Pichia pastoris.Highly Selective Cleavage of Cytokines and Chemokines by the Human Mast Cell Chymase and Neutrophil Cathepsin G.Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation.Extended cleavage specificity of human neutrophil cathepsin G: A low activity protease with dual chymase and tryptase-type specificities.
P2860
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P2860
The extended substrate specificity of the human mast cell chymase reveals a serine protease with well-defined substrate recognition profile.
description
2008 nî lūn-bûn
@nan
2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
name
The extended substrate specifi ...... substrate recognition profile.
@ast
The extended substrate specifi ...... substrate recognition profile.
@en
type
label
The extended substrate specifi ...... substrate recognition profile.
@ast
The extended substrate specifi ...... substrate recognition profile.
@en
prefLabel
The extended substrate specifi ...... substrate recognition profile.
@ast
The extended substrate specifi ...... substrate recognition profile.
@en
P2093
P2860
P356
P1476
The extended substrate specifi ...... substrate recognition profile.
@en
P2093
Lars Hellman
Maike Gallwitz
Mattias Enoksson
Mattias K Andersson
P2860
P304
P356
10.1093/INTIMM/DXN128
P577
2008-12-10T00:00:00Z