IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway.
about
The A20 deubiquitinase activity negatively regulates LMP1 activation of IRF7ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathwaysThe kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1AMPK phosphorylation of raptor mediates a metabolic checkpointA novel motif in the Crohn's disease susceptibility protein, NOD2, allows TRAF4 to down-regulate innate immune responsesRegulation and cellular roles of ubiquitin-specific deubiquitinating enzymesThe business of deubiquitination - location, location, locationDeubiquitinating enzymes in cellular signaling and disease regulationRegulation of inflammatory and antiviral signaling by A20.Effects of Imatinib Mesylate (Gleevec) on human islet NF-kappaB activation and chemokine production in vitroDevelopment of a high-throughput assay for identifying inhibitors of TBK1 and IKKεInactivation of BAD by IKK inhibits TNFα-induced apoptosis independently of NF-κB activationLipopolysaccharide-induced NF-κB nuclear translocation is primarily dependent on MyD88, but TNFα expression requires TRIF and MyD88Berbamine, a novel nuclear factor kappaB inhibitor, inhibits growth and induces apoptosis in human myeloma cells.O-glycosylation regulates ubiquitination and degradation of the anti-inflammatory protein A20 to accelerate atherosclerosis in diabetic ApoE-null mice.Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation.NF-κB Pathway in Autoinflammatory Diseases: Dysregulation of Protein Modifications by Ubiquitin Defines a New Category of Autoinflammatory Diseases.TAX1BP1 and A20 inhibit antiviral signaling by targeting TBK1-IKKi kinasesModeling the NF-κB mediated inflammatory response predicts cytokine waves in tissue.TNFAIP3 maintains intestinal barrier function and supports epithelial cell tight junctions.Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of rapamycin) by IκB kinase α (IKKα).IκB kinase α phosphorylation of TRAF4 downregulates innate immune signaling.Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses.Enterovirus 71 induces degradation of TRIM38, a potential E3 ubiquitin ligase.NF-κB inhibition protects against tumor-induced cardiac atrophy in vivo.Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcriptionHuman T-cell lymphotropic virus: a model of NF-κB-associated tumorigenesisNF-κB and cancer: a paradigm of Yin-Yang.Emerging significance of NLRs in inflammatory bowel disease.The inflammatory bowel disease (IBD) susceptibility genes NOD1 and NOD2 have conserved anti-bacterial roles in zebrafish.A systems view of the protein expression process.Zinc Prevents Abdominal Aortic Aneurysm Formation by Induction of A20-Mediated Suppression of NF-κB PathwayUpregulated Expression of A20 on Monocytes is Associated With Increased Severity of Acute-on-Chronic Hepatitis B Liver Failure: A Case-Control Study.Inhibition of A20 expression in tumor microenvironment exerts anti-tumor effect through inducing myeloid-derived suppressor cells apoptosisA20: linking a complex regulator of ubiquitylation to immunity and human diseaseSerine phosphorylation is critical for the activation of ubiquitin-specific protease 1 and its interaction with WD40-repeat protein UAF1.EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with SrcEGLN3 inhibition of NF-κB is mediated by prolyl hydroxylase-independent inhibition of IκB kinase γ ubiquitinationSubstrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease.Dysregulated NOD2 predisposes SAMP1/YitFc mice to chronic intestinal inflammation.
P2860
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P2860
IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway.
description
2007 nî lūn-bûn
@nan
2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
IkappaB kinase beta phosphoryl ...... tion of the NF-kappaB pathway.
@ast
IkappaB kinase beta phosphoryl ...... tion of the NF-kappaB pathway.
@en
IkappaB kinase beta phosphoryl ...... tion of the NF-kappaB pathway.
@nl
type
label
IkappaB kinase beta phosphoryl ...... tion of the NF-kappaB pathway.
@ast
IkappaB kinase beta phosphoryl ...... tion of the NF-kappaB pathway.
@en
IkappaB kinase beta phosphoryl ...... tion of the NF-kappaB pathway.
@nl
prefLabel
IkappaB kinase beta phosphoryl ...... tion of the NF-kappaB pathway.
@ast
IkappaB kinase beta phosphoryl ...... tion of the NF-kappaB pathway.
@en
IkappaB kinase beta phosphoryl ...... tion of the NF-kappaB pathway.
@nl
P2093
P2860
P356
P1476
IkappaB kinase beta phosphoryl ...... tion of the NF-kappaB pathway.
@en
P2093
Benjamin E Turk
Jessica E Hutti
John M Asara
P2860
P304
P356
10.1128/MCB.01101-07
P407
P577
2007-08-20T00:00:00Z