Direct measurement of a pK(a) near neutrality for the catalytic cytosine in the genomic HDV ribozyme using Raman crystallography.
about
Structural effects of nucleobase variations at key active site residue Ade38 in the hairpin ribozymeIdentification of an Imino Group Indispensable for Cleavage by a Small RibozymeThe structural basis of RNA-catalyzed RNA polymerization.A Transition-State Interaction Shifts Nucleobase Ionization toward Neutrality To Facilitate Small Ribozyme CatalysisSolution structure and metal ion binding sites of the human CPEB3 ribozyme's P4 domainChemistry and Biology of Self-Cleaving RibozymesA Two-Metal-Ion-Mediated Conformational Switching Pathway for HDV Ribozyme ActivationQuantum mechanical/molecular mechanical free energy simulations of the self-cleavage reaction in the hepatitis delta virus ribozyme.Intrinsic acid-base properties of a hexa-2'-deoxynucleoside pentaphosphate, d(ApGpGpCpCpT): neighboring effects and isomeric equilibria.Disparate HDV ribozyme crystal structures represent intermediates on a rugged free-energy landscape.The role of an active site Mg(2+) in HDV ribozyme self-cleavage: insights from QM/MM calculations.Role of tautomerism in RNA biochemistry.The pH dependence of hairpin ribozyme catalysis reflects ionization of an active site adenineBase ionization and ligand binding: how small ribozymes and riboswitches gain a foothold in a protein world.The glmS ribozyme tunes the catalytically critical pK(a) of its coenzyme glucosamine-6-phosphateCharacterization of the Structure and Dynamics of the HDV Ribozyme at Different Stages Along the Reaction Path.Constant pH Molecular Dynamics Simulations of Nucleic Acids in Explicit Solvent.Assessment of metal-assisted nucleophile activation in the hepatitis delta virus ribozyme from molecular simulation and 3D-RISM.Two Divalent Metal Ions and Conformational Changes Play Roles in the Hammerhead Ribozyme Cleavage Reaction.Multiscale methods for computational RNA enzymology.Transition State Features in the Hepatitis Delta Virus Ribozyme Reaction Revealed by Atomic Perturbations.pH-dependent dynamics of complex RNA macromoleculesTowards Accurate Prediction of Protonation Equilibrium of Nucleic Acids.Secondary structure confirmation and localization of Mg2+ ions in the mammalian CPEB3 ribozyme.Molecular dynamics suggest multifunctionality of an adenine imino group in acid-base catalysis of the hairpin ribozyme.Rapid and simple ribozymic aminoacylation using three conserved nucleotides.Raman crystallography of RNA.Two distinct catalytic strategies in the hepatitis δ virus ribozyme cleavage reaction.The DNA and RNA sugar-phosphate backbone emerges as the key player. An overview of quantum-chemical, structural biology and simulation studies.Nucleic acid catalysis: metals, nucleobases, and other cofactors.Properties and reactivity of nucleic acids relevant to epigenomics, transcriptomics, and therapeutics.Charged nucleobases and their potential for RNA catalysis.Experimental approaches for measuring pKa's in RNA and DNA.Quantum Mechanical/Molecular Mechanical Study of the HDV Ribozyme: Impact of the Catalytic Metal Ion on the Mechanism.Inverse thio effects in the hepatitis delta virus ribozyme reveal that the reaction pathway is controlled by metal ion charge density.A catalytic metal ion interacts with the cleavage Site G.U wobble in the HDV ribozyme.Metal binding motif in the active site of the HDV ribozyme binds divalent and monovalent ions.Competition between Co(NH(3)(6)3+ and inner sphere Mg2+ ions in the HDV ribozyme.Identification of the catalytic Mg²⁺ ion in the hepatitis delta virus ribozyme.Thio effects and an unconventional metal ion rescue in the genomic hepatitis delta virus ribozyme.
P2860
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P2860
Direct measurement of a pK(a) near neutrality for the catalytic cytosine in the genomic HDV ribozyme using Raman crystallography.
description
2007 nî lūn-bûn
@nan
2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Direct measurement of a pK
@nl
Direct measurement of a pK(a) ...... e using Raman crystallography.
@ast
Direct measurement of a pK(a) ...... e using Raman crystallography.
@en
type
label
Direct measurement of a pK
@nl
Direct measurement of a pK(a) ...... e using Raman crystallography.
@ast
Direct measurement of a pK(a) ...... e using Raman crystallography.
@en
prefLabel
Direct measurement of a pK
@nl
Direct measurement of a pK(a) ...... e using Raman crystallography.
@ast
Direct measurement of a pK(a) ...... e using Raman crystallography.
@en
P2093
P356
P1476
Direct measurement of a pK(a) ...... e using Raman crystallography.
@en
P2093
Durga M Chadalavada
Elaine Chase
Jui-Hui Chen
Paul R Carey
Philip C Bevilacqua
Rieko Yajima
P304
13335-13342
P356
10.1021/JA0743893
P407
P577
2007-10-09T00:00:00Z