Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication
about
The human selenoproteome: recent insights into functions and regulationMolecular mechanisms of thioredoxin and glutaredoxin as hydrogen donors for Mammalian s phase ribonucleotide reductaseSec-containing TrxR1 is essential for self-sufficiency of cells by control of glucose-derived H2O2.Cell death by SecTRAPs: thioredoxin reductase as a prooxidant killer of cellsJS-K, a nitric oxide prodrug, has enhanced cytotoxicity in colon cancer cells with knockdown of thioredoxin reductase 1TXNRD1 Is an Unfavorable Prognostic Factor for Patients with Hepatocellular Carcinoma.Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assayDeficiency in the 15-kDa selenoprotein inhibits tumorigenicity and metastasis of colon cancer cells.Hepatocytes lacking thioredoxin reductase 1 have normal replicative potential during development and regeneration.Redox regulatory mechanism of transnitrosylation by thioredoxin.Profilin-1 overexpression in MDA-MB-231 breast cancer cells is associated with alterations in proteomics biomarkers of cell proliferation, survival, and motility as revealed by global proteomics analyses.Alteration of thioredoxin reductase 1 levels in elucidating cancer etiology.The Outcome of Selenium and Vitamin E Cancer Prevention Trial (SELECT) reveals the need for better understanding of selenium biology.Deletion of glutathione peroxidase-2 inhibits azoxymethane-induced colon cancer development.Abrogated thioredoxin system causes increased sensitivity to TNF-α-induced apoptosis via enrichment of p-ERK 1/2 in the nucleus.The 15kDa selenoprotein and thioredoxin reductase 1 promote colon cancer by different pathwaysHepatocyte DNA replication in growing liver requires either glutathione or a single allele of txnrd1.CLIC4 is a tumor suppressor for cutaneous squamous cell cancer.A possible predictive marker of progression for hepatocellular carcinomaThioredoxin reductase 1 deficiency enhances selenite toxicity in cancer cells via a thioredoxin-independent mechanismThioredoxin and thioredoxin target proteins: from molecular mechanisms to functional significance.Contrasting roles of dietary selenium and selenoproteins in chemically induced hepatocarcinogenesis.Thioredoxin Reductase 1 Expression and Castration-recurrent Growth of Prostate CancerSelenium supranutrition: are the potential benefits of chemoprevention outweighed by the promotion of diabetes and insulin resistance?Auranofin disrupts selenium metabolism in Clostridium difficile by forming a stable Au-Se adduct.Identification of Michael acceptor-centric pharmacophores with substituents that yield strong thioredoxin reductase inhibitory character correlated to antiproliferative activity.Simultaneous knockdown of the expression of two genes using multiple shRNAs and subsequent knock-in of their expression.Exposure to monomethylarsonous acid (MMA(III)) leads to altered selenoprotein synthesis in a primary human lung cell model.Selenoproteins that function in cancer prevention and promotion.Molecular mechanisms by which selenoproteins affect cancer risk and progression.Selenium as an essential micronutrient: roles in cell cycle and apoptosis.Resolution of oxidative stress by thioredoxin reductase: Cysteine versus selenocysteine.Targeting selenium metabolism and selenoproteins: novel avenues for drug discoveryEpigenetic and antioxidant effects of dietary isothiocyanates and selenium: potential implications for cancer chemoprevention.Thioredoxin and glutaredoxin-mediated redox regulation of ribonucleotide reductase.Thioredoxin reductase-1 knock down does not result in thioredoxin-1 oxidation.The role of thioredoxin reductase 1 in melanoma metabolism and metastasis.Evaluation of selenite effects on selenoproteins and cytokinome in human hepatoma cell lines.Glutathione and glutaredoxin act as a backup of human thioredoxin reductase 1 to reduce thioredoxin 1 preventing cell death by aurothioglucose.Effects of redox modulation by inhibition of thioredoxin reductase on radiosensitivity and gene expression.
P2860
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P2860
Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication
description
2007 nî lūn-bûn
@nan
2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Targeting thioredoxin reductas ...... ent growth and DNA replication
@ast
Targeting thioredoxin reductas ...... ent growth and DNA replication
@en
Targeting thioredoxin reductas ...... nt growth and DNA replication.
@nl
type
label
Targeting thioredoxin reductas ...... ent growth and DNA replication
@ast
Targeting thioredoxin reductas ...... ent growth and DNA replication
@en
Targeting thioredoxin reductas ...... nt growth and DNA replication.
@nl
prefLabel
Targeting thioredoxin reductas ...... ent growth and DNA replication
@ast
Targeting thioredoxin reductas ...... ent growth and DNA replication
@en
Targeting thioredoxin reductas ...... nt growth and DNA replication.
@nl
P2093
P2860
P1433
P1476
Targeting thioredoxin reductas ...... ent growth and DNA replication
@en
P2093
Bradley A Carlson
Dolph L Hatfield
Min-Hyuk Yoo
Vadim N Gladyshev
Xue-Ming Xu
P2860
P356
10.1371/JOURNAL.PONE.0001112
P407
P577
2007-10-31T00:00:00Z