RNAi screening of the tyrosine kinome identifies therapeutic targets in acute myeloid leukemia.
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Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cellsCell-cycle dependent expression of a translocation-mediated fusion oncogene mediates checkpoint adaptation in rhabdomyosarcomaEfficacy of NS-018, a potent and selective JAK2/Src inhibitor, in primary cells and mouse models of myeloproliferative neoplasmsAntibody-siRNA conjugates: drugging the undruggable for anti-leukemic therapy.Synthetic protection short interfering RNA screen reveals glyburide as a novel radioprotector.Small interfering RNA screen for phosphatases involved in IgE-mediated mast cell degranulation.Clinical targeting of mutated and wild-type protein tyrosine kinases in cancer.PDGFRβ reverses EphB4 signaling in alveolar rhabdomyosarcoma.CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasmsGTPase regulator associated with the focal adhesion kinase (GRAF) transcript was down-regulated in patients with myeloid malignanciesKinase pathway dependence in primary human leukemias determined by rapid inhibitor screening.Rapid Identification of Therapeutic Targets in Hematologic Malignancies via Functional Genomics.Functional RNAi screen targeting cytokine and growth factor receptors reveals oncorequisite role for interleukin-2 gamma receptor in JAK3-mutation-positive leukemia.Crosstalk between KIT and FGFR3 Promotes Gastrointestinal Stromal Tumor Cell Growth and Drug ResistanceJAK Kinases in Health and Disease: An UpdateIdentification of WEE1 as a potential molecular target in cancer cells by RNAi screening of the human tyrosine kinome.Specific Jak3 Downregulation in Lymphocytes Impairs γc Cytokine Signal Transduction and Alleviates Antigen-driven Inflammation In VivoCrosstalk between ROR1 and the Pre-B cell receptor promotes survival of t(1;19) acute lymphoblastic leukemia.TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemiaRNAi screen for rapid therapeutic target identification in leukemia patients.Ponatinib overcomes FGF2-mediated resistance in CML patients without kinase domain mutations.Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinasesCD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia.Can kinomics and proteomics bridge the gap between pediatric cancers and newly designed kinase inhibitors?Discovery of siRNA lipid nanoparticles to transfect suspension leukemia cells and provide in vivo delivery capability.Distinct signalling pathways for mutated KIT(V560G) and KIT(D816V) in mastocytosis.Identification of new possible targets for leukemia treatment by kinase activity profiling.FLT3/ ITD regulates leukaemia cell adhesion through α4β1 integrin and Pyk2 signalling.The Src homology-2 protein Shb modulates focal adhesion kinase signaling in a BCR-ABL myeloproliferative disorder causing accelerated progression of disease.Systematic analysis of RNAi reports identifies dismal commonality at gene-level and reveals an unprecedented enrichment in pooled shRNA screens.RNAi Screening of Leukemia Cells Using ElectroporationFGF2 from Marrow Microenvironment Promotes Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia.Kinase profiling of liposarcomas using RNAi and drug screening assays identified druggable targets.SKLB1028, a novel oral multikinase inhibitor of EGFR, FLT3 and Abl, displays exceptional activity in models of FLT3-driven AML and considerable potency in models of CML harboring Abl mutants.
P2860
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P2860
RNAi screening of the tyrosine kinome identifies therapeutic targets in acute myeloid leukemia.
description
2007 nî lūn-bûn
@nan
2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
RNAi screening of the tyrosine ...... ets in acute myeloid leukemia.
@ast
RNAi screening of the tyrosine ...... ets in acute myeloid leukemia.
@en
RNAi screening of the tyrosine ...... ets in acute myeloid leukemia.
@nl
type
label
RNAi screening of the tyrosine ...... ets in acute myeloid leukemia.
@ast
RNAi screening of the tyrosine ...... ets in acute myeloid leukemia.
@en
RNAi screening of the tyrosine ...... ets in acute myeloid leukemia.
@nl
prefLabel
RNAi screening of the tyrosine ...... ets in acute myeloid leukemia.
@ast
RNAi screening of the tyrosine ...... ets in acute myeloid leukemia.
@en
RNAi screening of the tyrosine ...... ets in acute myeloid leukemia.
@nl
P2093
P2860
P50
P1433
P1476
RNAi screening of the tyrosine ...... ets in acute myeloid leukemia.
@en
P2093
Amie S Corbin
Denise K Walters
Heidi Erickson
Jason Oost
Marc Loriaux
Mary Luttropp
Michael W Deininger
Stephanie G Willis
Thomas O'Hare
P2860
P304
P356
10.1182/BLOOD-2007-06-097253
P407
P577
2007-11-19T00:00:00Z