Crosstalk between ROR1 and the Pre-B cell receptor promotes survival of t(1;19) acute lymphoblastic leukemia. - Wikidata - wikimedia - TriplyDB

Crosstalk between ROR1 and the Pre-B cell receptor promotes survival of t(1;19) acute lymphoblastic leukemia.

Crosstalk between ROR1 and the Pre-B cell receptor promotes survival of t(1;19) acute lymphoblastic leukemia.

http://www.wikidata.org/entity/Q36406203

about

ROR1, an embryonic protein with an emerging role in cancer biology Targeting the B-cell receptor signaling pathway in B lymphoid malignancies The role of Ryk and Ror receptor tyrosine kinases in Wnt signal transduction microRNA regulation of Wnt signaling pathways in development and disease Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML Identification of drug combinations containing imatinib for treatment of BCR-ABL+ leukemias Receptor tyrosine kinase gene expression profiles of Ewing sarcomas reveal ROR1 as a potential therapeutic target in metastatic disease.Idelalisib sensitivity and mechanisms of disease progression in relapsed TCF3-PBX1 acute lymphoblastic leukemia ROR1 expression as a biomarker for predicting prognosis in patients with colorectal cancer.A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.Safety of targeting ROR1 in primates with chimeric antigen receptor-modified T cells.Crosstalk between KIT and FGFR3 Promotes Gastrointestinal Stromal Tumor Cell Growth and Drug Resistance Sleeping Beauty Transposition of Chimeric Antigen Receptors Targeting Receptor Tyrosine Kinase-Like Orphan Receptor-1 (ROR1) into Diverse Memory T-Cell Populations.IGF1R- and ROR1-Specific CAR T Cells as a Potential Therapy for High Risk Sarcomas.Rationale for targeting the pre-B-cell receptor signaling pathway in acute lymphoblastic leukemia.Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options.Targeting ROR1 identifies new treatment strategies in hematological cancers.Personalizing therapy in advanced non-small cell lung cancer Morc3 mutant mice exhibit reduced cortical area and thickness, accompanied by altered haematopoietic stem cells niche and bone cell differentiation.Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells.ROR1 is a novel prognostic biomarker in patients with lung adenocarcinoma.ROR1 can interact with TCL1 and enhance leukemogenesis in Eμ-TCL1 transgenic mice.Hypoxia induces phenotypic plasticity and therapy resistance in melanoma via the tyrosine kinase receptors ROR1 and ROR2.Functional genomics for personalized cancer therapy.Imaging and Force Recognition of Single Molecular Behaviors Using Atomic Force Microscopy.Comparison of methods to identify aberrant expression patterns in individual patients: augmenting our toolkit for precision medicine.A ROR1-HER3-lncRNA signalling axis modulates the Hippo-YAP pathway to regulate bone metastasis.Dawn of the dead: protein pseudokinases signal new adventures in cell biology.Design and implementation of adoptive therapy with chimeric antigen receptor-modified T cells.Mechanisms of pre-B-cell receptor checkpoint control and its oncogenic subversion in acute lymphoblastic leukemia.Receptor tyrosine kinase-like orphan receptor 1: a novel target for cancer immunotherapy.The pre-B-cell receptor checkpoint in acute lymphoblastic leukaemia.Ibrutinib-A double-edge sword in cancer and autoimmune disorders.Ibrutinib inhibits pre-BCR+ B-cell acute lymphoblastic leukemia progression by targeting BTK and BLK.ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1 Pre-BCR signaling in precursor B-cell acute lymphoblastic leukemia regulates PI3K/AKT, FOXO1 and MYC, and can be targeted by SYK inhibition.The Emerging Role of MORC Family Proteins in Cancer Development and Bone Homeostasis.WNT receptors profile expression in mature blood cells and immature leukemic cells: RYK emerges as a hallmark receptor of acute leukemia.ROR1 contributes to melanoma cell growth and migration by regulating N-cadherin expression via the PI3K/Akt pathway.Mechanisms of tumor cell resistance to the current targeted-therapy agents.

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Crosstalk between ROR1 and the Pre-B cell receptor promotes survival of t(1;19) acute lymphoblastic leukemia.

http://www.wikidata.org/entity/Q36406203

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Crosstalk between ROR1 and the ...... acute lymphoblastic leukemia.

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Behzad Kharabi Masouleh

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Marc M Loriaux

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Markus Muschen

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P2860

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia

Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a

Pre-B cell antigen receptor-mediated signal inhibits CD24-induced apoptosis in human pre-B cells

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

Chemotherapeutic agents circumvent emergence of dasatinib-resistant BCR-ABL kinase mutations in a precise mouse model of Philadelphia chromosome-positive acute lymphoblastic leukemia

AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance

Crystal Structures of Human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating Protein (RabGAP) Domains Reveal Critical Elements for GLUT4 Translocation

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK--functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling

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