Polyglutamine genes interact to modulate the severity and progression of neurodegeneration in Drosophila.
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Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALSStructural basis of binding of P-body-associated proteins GW182 and ataxin-2 by the Mlle domain of poly(A)-binding proteinMotor Dysfunctions and Neuropathology in Mouse Models of Spinocerebellar Ataxia Type 2: A Comprehensive ReviewAtaxin-2 modulates the levels of Grb2 and SRC but not ras signaling.Guide to understanding Drosophila models of neurodegenerative diseases.Polyglutamine-rich suppressors of huntingtin toxicity act upstream of Hsp70 and Sti1 in spatial quality control of amyloid-like proteins.Conserved genes act as modifiers of invertebrate SMN loss of function defectsDrosophila melanogaster in the study of human neurodegeneration.Poly(A)-binding proteins are required for diverse biological processes in metazoans.Neurodegenerative models in Drosophila: polyglutamine disorders, Parkinson disease, and amyotrophic lateral sclerosis.Prion-like proteins sequester and suppress the toxicity of huntingtin exon 1.Axon injury and regeneration in the adult DrosophilaLarge-scale screen for modifiers of ataxin-3-derived polyglutamine-induced toxicity in Drosophila.Ataxin-2 intermediate-length polyglutamine expansions in European ALS patientsThe Ataxin-2 protein is required for microRNA function and synapse-specific long-term olfactory habituation.Protein interacting with C kinase (PICK1) is a suppressor of spinocerebellar ataxia 3-associated neurodegeneration in Drosophila.Drosophila models of proteinopathies: the little fly that could.Drosophila models reveal novel insights into mechanisms underlying neurodegeneration.Drosophila melanogaster as a model organism of brain diseasesDrosophila ataxin-2 gene encodes two differentially expressed isoforms and its function in larval fat body is crucial for development of peripheral tissuesPreventing Ataxin-3 protein cleavage mitigates degeneration in a Drosophila model of SCA3.Recent advances in using Drosophila to model neurodegenerative diseases.FMRP and Ataxin-2 function together in long-term olfactory habituation and neuronal translational control.Genetic complexity in a Drosophila model of diabetes-associated misfolded human proinsulin.Interplay between protein homeostasis networks in protein aggregation and proteotoxicityConsensus paper: pathological mechanisms underlying neurodegeneration in spinocerebellar ataxias.Neurodegenerative diseases: Lessons from genome-wide screens in small model organisms.Chaperones in Polyglutamine Aggregation: Beyond the Q-Stretch.Modifiers and mechanisms of multi-system polyglutamine neurodegenerative disorders: lessons from fly models.Fruitful research: drug target discovery for neurodegenerative diseases in Drosophila.From pathways to targets: understanding the mechanisms behind polyglutamine disease.Genetic ablation of ataxin-2 increases several global translation factors in their transcript abundance but decreases translation rate.Overexpression of cystathionine γ-lyase suppresses detrimental effects of spinocerebellar ataxia type 3.Candida albicans Is Resistant to Polyglutamine Aggregation and ToxicityMouse ataxin-3 functional knock-out model.Atxn2 Knockout and CAG42-Knock-in Cerebellum Shows Similarly Dysregulated Expression in Calcium Homeostasis Pathway.Impaired retrograde transport by the Dynein/Dynactin complex contributes to Tau-induced toxicity.Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease.Wild type huntingtin toxicity in yeast: Implications for the role of amyloid cross-seeding in polyQ diseases.The splicing factor Prp31 is essential for photoreceptor development in Drosophila.
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P2860
Polyglutamine genes interact to modulate the severity and progression of neurodegeneration in Drosophila.
description
2008 nî lūn-bûn
@nan
2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Polyglutamine genes interact t ...... urodegeneration in Drosophila.
@ast
Polyglutamine genes interact t ...... urodegeneration in Drosophila.
@en
Polyglutamine genes interact t ...... urodegeneration in Drosophila.
@nl
type
label
Polyglutamine genes interact t ...... urodegeneration in Drosophila.
@ast
Polyglutamine genes interact t ...... urodegeneration in Drosophila.
@en
Polyglutamine genes interact t ...... urodegeneration in Drosophila.
@nl
prefLabel
Polyglutamine genes interact t ...... urodegeneration in Drosophila.
@ast
Polyglutamine genes interact t ...... urodegeneration in Drosophila.
@en
Polyglutamine genes interact t ...... urodegeneration in Drosophila.
@nl
P2860
P1433
P1476
Polyglutamine genes interact t ...... urodegeneration in Drosophila.
@en
P2093
Derek Lessing
P2860
P356
10.1371/JOURNAL.PBIO.0060029
P407
P577
2008-02-01T00:00:00Z