Human VRK1 is an early response gene and its loss causes a block in cell cycle progression.
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VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancerMacro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase VRK1 during interphaseHuman VRK2 (vaccinia-related kinase 2) modulates tumor cell invasion by hyperactivation of NFAT1 and expression of cyclooxygenase-2Plk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentationProteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activitiesHuman VRK2 modulates apoptosis by interaction with Bcl-xL and regulation of BAX gene expressionVRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damageVaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damageVRK1 chromatin kinase phosphorylates H2AX and is required for foci formation induced by DNA damageVRK2 anchors KSR1-MEK1 to endoplasmic reticulum forming a macromolecular complex that compartmentalizes MAPK signalingStructure of the Pseudokinase VRK3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding SiteAnalysis of kinase gene expression patterns across 5681 human tissue samples reveals functional genomic taxonomy of the kinomeLuteolin suppresses cancer cell proliferation by targeting vaccinia-related kinase 1The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53The oncogenic EWS-FLI1 protein binds in vivo GGAA microsatellite sequences with potential transcriptional activation functionVaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage responseAllelotyping identification of genomic alterations in rectal chromosomally unstable tumors without preoperative treatment.Vaccinia-related kinase 1 is required for the maintenance of undifferentiated spermatogonia in mouse male germ cellsDownregulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway.Differential inhibitor sensitivity between human kinases VRK1 and VRK2.Functional disruption of the moloney murine leukemia virus preintegration complex by vaccinia-related kinases.VRK2 identifies a subgroup of primary high-grade astrocytomas with a better prognosisRewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas.VRK1 regulates Cajal body dynamics and protects coilin from proteasomal degradation in cell cycleProtein kinase VRK-1 regulates cell invasion and EGL-17/FGF signaling in Caenorhabditis elegans.Predictive value of vrk 1 and 2 for rectal adenocarcinoma response to neoadjuvant chemoradiation therapy: a retrospective observational cohort studyUrsolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells.HnRNP A1 phosphorylated by VRK1 stimulates telomerase and its binding to telomeric DNA sequence.Vaccinia-related kinase 1 promotes hepatocellular carcinoma by controlling the levels of cell cycle regulators associated with G1/S transition.Molecular genetic analysis of VRK1 in mammary epithelial cells: depletion slows proliferation in vitro and tumor growth and metastasis in vivo.Spinal muscular atrophy with pontocerebellar hypoplasia is caused by a mutation in the VRK1 gene.Genetic and Targeted eQTL Mapping Reveals Strong Candidate Genes Modulating the Stress Response During Chicken Domestication.Deletion of the Vaccinia Virus B1 Kinase Reveals Essential Functions of This Enzyme Complemented Partly by the Homologous Cellular Kinase VRK2.Expression of vaccinia-related kinase 1 (VRK1) accelerates cell proliferation but overcomes cell adhesion mediated drug resistance (CAM-DR) in multiple myeloma.The Homologous Recombination Machinery Orchestrates Post-replication DNA Repair During Self-renewal of Mouse Embryonic Stem Cells.Hypoxia and miscoupling between reduced energy efficiency and signaling to cell proliferation drive cancer to grow increasingly faster.VRK1 promotes cisplatin resistance by up-regulating c-MYC via c-Jun activation and serves as a therapeutic target in esophageal squamous cell carcinoma.Novel motor phenotypes in patients with VRK1 mutations without pontocerebellar hypoplasia.Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiationVRK1 and AURKB form a complex that cross inhibit their kinase activity and the phosphorylation of histone H3 in the progression of mitosis.
P2860
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P2860
Human VRK1 is an early response gene and its loss causes a block in cell cycle progression.
description
2008 nî lūn-bûn
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2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2008年の論文
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2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Human VRK1 is an early respons ...... ock in cell cycle progression.
@ast
Human VRK1 is an early respons ...... ock in cell cycle progression.
@en
Human VRK1 is an early respons ...... ock in cell cycle progression.
@nl
type
label
Human VRK1 is an early respons ...... ock in cell cycle progression.
@ast
Human VRK1 is an early respons ...... ock in cell cycle progression.
@en
Human VRK1 is an early respons ...... ock in cell cycle progression.
@nl
prefLabel
Human VRK1 is an early respons ...... ock in cell cycle progression.
@ast
Human VRK1 is an early respons ...... ock in cell cycle progression.
@en
Human VRK1 is an early respons ...... ock in cell cycle progression.
@nl
P2860
P1433
P1476
Human VRK1 is an early respons ...... ock in cell cycle progression.
@en
P2093
Alberto Valbuena
Inmaculada López-Sánchez
P2860
P356
10.1371/JOURNAL.PONE.0001642
P407
P577
2008-02-20T00:00:00Z