The role of the human Fc receptor Fc gamma RIIA in the immune clearance of platelets: a transgenic mouse model.
about
Monoclonal antibodies capable of discriminating the human inhibitory Fcgamma-receptor IIB (CD32B) from the activating Fcgamma-receptor IIA (CD32A): biochemical, biological and functional characterizationPlatelets and their role in cancer evolution and immune systemFcγ receptors and ligands and cardiovascular diseaseStructural Basis for Fc RIIa Recognition of Human IgG and Formation of Inflammatory Signaling ComplexesMonocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia.Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo.Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopeniaRole of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications.PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model.CalDAG-GEFI deficiency protects mice in a novel model of Fcγ RIIA-mediated thrombosis and thrombocytopenia.Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation.CalDAG-GEFI deficiency protects mice from FcγRIIa-mediated thrombotic thrombocytopenia induced by CD40L and β2GPI immune complexesPlatelet Activation and Thrombus Formation over IgG Immune Complexes Requires Integrin αIIbβ3 and Lyn Kinase.CD32a antibodies induce thrombocytopenia and type II hypersensitivity reactions in FCGR2A mice.Anti-miR-148a regulates platelet FcγRIIA signaling and decreases thrombosis in vivo in mice.Contribution of Human FcγRs to Disease with Evidence from Human Polymorphisms and Transgenic Animal StudiesCLEC-2 expression is maintained on activated platelets and on platelet microparticles.FcγRIV deletion reveals its central role for IgG2a and IgG2b activity in vivo.Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators.Platelets and infections - complex interactions with bacteria.Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes.Differential Fc-Receptor Engagement Drives an Anti-tumor Vaccinal Effect.Human FcγRIIA induces anaphylactic and allergic reactions.Mouse model recapitulating human Fcγ receptor structural and functional diversityHigh synovial expression of the inhibitory FcgammaRIIb in rheumatoid arthritisIdentification of FcgammaRIIa as the ITAM-bearing receptor mediating alphaIIbbeta3 outside-in integrin signaling in human plateletsFunctional expression of IgA receptor FcalphaRI on human platelets.Aglycosylated immunoglobulin G1 variants productively engage activating Fc receptorsIdentification of novel Syk-independent functional roles of FcγRIIa in platelet outside-in signaling using transgenic mice expressing human FcγRIIa.Neutrophils mediate antibody-induced antitumor effects in mice.Mechanisms of immune complex-mediated neutrophil recruitment and tissue injury.Platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling and vascular integrity.Inhibitory Fcγ receptor engagement drives adjuvant and anti-tumor activities of agonistic CD40 antibodies.Amplification of bacteria-induced platelet activation is triggered by FcγRIIA, integrin αIIbβ3, and platelet factor 4.Reciprocal signaling by integrin and nonintegrin receptors during collagen activation of platelets.FcγRIIB prevents inflammatory type I IFN production from plasmacytoid dendritic cells during a viral memory response.Mice Expressing Low Levels of CalDAG-GEFI Exhibit Markedly Impaired Platelet Activation With Minor Impact on Hemostasis.The pathophysiology of anaphylaxis.Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration.Diversification of IgG effector functions.
P2860
Q24655389-4F97CB88-7E21-408F-9DA5-D9B3E281497CQ26769754-79BDAC74-20BC-4331-9310-9BA74E5C7D49Q27021449-0F74D444-55BB-4E95-8DC5-CB412A81601AQ27671845-71A8C50B-EFC1-4219-9856-D4E2F07B441CQ30497774-6A399D22-0B35-412A-BB60-3FD9A8412BCEQ30537304-BB3050AD-834C-4430-BC12-7193471A744EQ30840169-774371AE-41CB-474C-A542-043021A177FCQ33369316-B4534D02-652F-4BFB-9E39-F544398471F2Q33392880-74865C1B-365E-4AA3-9503-2260E6F8E3D3Q33395687-02AC37AD-77D6-4BF9-8A34-1D09DBED280DQ33416935-9DAEC035-4FD7-4617-8680-DBCA3EDA4759Q33418006-6CA83536-DAC9-4E43-BDA1-1B3018457A46Q33425285-39BFB4D6-3378-495F-B3AA-F7FEA14C33E2Q33426121-67FB6314-07B6-417D-B1EF-EA7D590CE125Q33427174-C9375421-DC2B-4B63-8201-10D5BF45CF41Q33686907-62FDCBC1-8823-4D8C-B451-1D626D20948CQ34284335-51664FF5-B4CF-40D1-A4DF-433DE2A7DB24Q34320482-2266237C-C40E-4193-B680-D1DE2E8F59CEQ35064907-6FB05780-8CB8-4892-8E16-47C29342E9D2Q35124418-5A0BF1DF-7872-4DAF-831F-6B9563B2937AQ35346534-66329AC4-4F43-452C-9D04-9E59B548C7AAQ35639002-E6BC2324-CA0B-476E-96D3-6F118D369484Q35849322-8A845F20-6F26-4FC8-BEC5-D29B72AE2E8EQ35924857-6D754AAE-E946-447B-BC41-33623A2F3A00Q36392292-9E5ACB36-E726-47AB-B36B-AC493D02F26DQ36915881-B150AB20-720F-487D-9C81-0DE52F2425B8Q37039019-2D8F7FF6-9165-4B3C-AD75-3C8D5E9DCE88Q37068434-1AF22720-BE28-4A60-8FE6-E6AB2D4C9ECDQ37156417-0C920337-9F54-445D-B654-5C135EC17D23Q37272029-017DAEE1-D99F-4DC7-884E-B5845B89589CQ37436638-40A84C29-B2E1-4A2B-B3B0-F666349A695EQ37725087-6CC01F7F-6FC5-4F13-8A66-66F3E3643EAEQ38275268-792B1712-013F-44E1-A665-95A12C10B375Q39675280-8D2F1B20-A97F-4A28-9967-6D49E6978739Q39777884-4D23BEB3-0948-478B-8269-C37720B1C0B6Q39868598-98CC4526-C8A2-4026-A687-B2233713CD20Q40958997-63B96BE1-BDF4-47FD-A698-131D1D8F1FDFQ47810222-77F7A40F-3340-4D40-9759-BF7DDF3D43D7Q47828127-88F64C6C-4D69-467E-9983-BDD74A800305Q53313488-0C8F2357-4240-4A06-8CE8-D43062AC0CD9
P2860
The role of the human Fc receptor Fc gamma RIIA in the immune clearance of platelets: a transgenic mouse model.
description
1999 nî lūn-bûn
@nan
1999 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
The role of the human Fc recep ...... ets: a transgenic mouse model.
@ast
The role of the human Fc recep ...... ets: a transgenic mouse model.
@en
The role of the human Fc recep ...... ets: a transgenic mouse model.
@nl
type
label
The role of the human Fc recep ...... ets: a transgenic mouse model.
@ast
The role of the human Fc recep ...... ets: a transgenic mouse model.
@en
The role of the human Fc recep ...... ets: a transgenic mouse model.
@nl
prefLabel
The role of the human Fc recep ...... ets: a transgenic mouse model.
@ast
The role of the human Fc recep ...... ets: a transgenic mouse model.
@en
The role of the human Fc recep ...... ets: a transgenic mouse model.
@nl
P2093
P1476
The role of the human Fc recep ...... ets: a transgenic mouse model.
@en
P2093
McKenzie SE
Schreiber AD
Schwartz E
P304
P407
P577
1999-04-01T00:00:00Z