CalDAG-GEFI deficiency protects mice in a novel model of Fcγ RIIA-mediated thrombosis and thrombocytopenia. - Wikidata - wikimedia - TriplyDB

CalDAG-GEFI deficiency protects mice in a novel model of Fcγ RIIA-mediated thrombosis and thrombocytopenia.

CalDAG-GEFI deficiency protects mice in a novel model of Fcγ RIIA-mediated thrombosis and thrombocytopenia.

http://www.wikidata.org/entity/Q33395687

about

Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding Platelets and their role in cancer evolution and immune system Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis.Advances in the pathophysiology and treatment of heparin-induced thrombocytopenia.CalDAG-GEFI deficiency protects mice from FcγRIIa-mediated thrombotic thrombocytopenia induced by CD40L and β2GPI immune complexes Human platelet IgG Fc receptor FcγRIIA in immunity and thrombosis.Anti-miR-148a regulates platelet FcγRIIA signaling and decreases thrombosis in vivo in mice.Dimerization of glycoprotein Ibα is not sufficient to induce platelet clearance.Contribution of Human FcγRs to Disease with Evidence from Human Polymorphisms and Transgenic Animal Studies CLEC-2 expression is maintained on activated platelets and on platelet microparticles.Impact of elevated plasma serotonin on global gene expression of murine megakaryocytes.Platelet Extracellular Regulated Protein Kinase 5 Is a Redox Switch and Triggers Maladaptive Platelet Responses and Myocardial Infarct Expansion Tissue factor-positive tumor microvesicles activate platelets and enhance thrombosis in mice.Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction.Platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling and vascular integrity.RasGRP Ras guanine nucleotide exchange factors in cancer.Mouse and human FcR effector functions.Glycans and the platelet life cycle.Ras guanyl nucleotide releasing protein 2 affects cell viability and cell-matrix adhesion in ECV304 endothelial cells.Mice Expressing Low Levels of CalDAG-GEFI Exhibit Markedly Impaired Platelet Activation With Minor Impact on Hemostasis.Losing your GRP on platelet activation.Chest pain, dyspnea, petechiae, and melena in a 58-year-old woman - what is it?Activation of platelet protein kinase C by ultraviolet light B mediates platelet transfusion-related acute lung injury in a two-event animal model.Fc-independent immune thrombocytopenia via mechanomolecular signaling in platelets.Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration.Biology of Platelet Purinergic Receptors and Implications for Platelet Heterogeneity.

P2860

Q24299751-837503BC-FEA4-4FDE-A893-0052021D6CF3 Q26769754-014CAF05-3471-4DDC-B274-64FB567AE661 Q30698911-802D22C5-C03F-48EE-B978-F60FE423D2FB Q33416269-86ACBD41-27EE-4532-AD02-A52243ED5F09 Q33418006-A3EE42CD-347B-4162-8BF6-603D2DABB2FD Q33422231-41E67DC1-C40D-4B37-912B-E17CC67EF392 Q33427174-4CEF4CB8-F89C-4AAA-9C2A-ED2CBAC03FF5 Q33428363-BD86A114-74FB-4917-8CB4-1EEA90541650 Q33686907-005430D3-017F-4F22-9394-43AC622068EB Q34284335-0D4A5AAD-2429-4C94-8549-4F73BB4FC077 Q34980796-11936E0B-0929-485D-9CF8-82EB63AB0DA9 Q35940530-BFB69E7E-3361-4DD3-8500-A3172606D9D8 Q36470049-04157513-4123-4C23-B45D-D0C1753283F7 Q37228334-C719DAF1-E457-4099-82FF-867BE0D67793 Q37725087-E5664CE4-4846-429C-AFC5-BA2047E3393B Q38205441-143B9E87-3C86-4AEC-825B-EC1D772249B0 Q38615349-2D77078E-3BF9-42CB-B094-040F6FA44539 Q38822895-428EF8AC-7DE5-4BE5-BB9C-E6439B139B57 Q39170092-E8567DBA-145B-4F15-8D8A-AC93EF924807 Q40958997-8C3A7ED2-042C-419B-8EF0-33F4A84AE8AA Q41910005-A26732AD-9DA6-44F1-9424-5E1F23476EE5 Q44123338-EFB436A2-4662-4727-8D67-E9CF9FDBB635 Q46626259-9597885E-FED4-4F94-89DC-F2D66466DA31 Q47285531-3BCA95EA-AEAC-41E3-BD1F-3115ED61B83C Q47828127-EF806708-5832-4625-9593-450CAA409D9B Q50023648-3C82B069-B3DB-4F1E-B47C-091D34977489

P2860

CalDAG-GEFI deficiency protects mice in a novel model of Fcγ RIIA-mediated thrombosis and thrombocytopenia.

http://www.wikidata.org/entity/Q33395687

description

2011 nî lūn-bûn

@nan

2011 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

CalDAG-GEFI deficiency protect ...... rombosis and thrombocytopenia.

@ast

CalDAG-GEFI deficiency protect ...... rombosis and thrombocytopenia.

@en

type

label

CalDAG-GEFI deficiency protect ...... rombosis and thrombocytopenia.

@ast

CalDAG-GEFI deficiency protect ...... rombosis and thrombocytopenia.

@en

prefLabel

CalDAG-GEFI deficiency protect ...... rombosis and thrombocytopenia.

@ast

CalDAG-GEFI deficiency protect ...... rombosis and thrombocytopenia.

@en

P1433

Q33395687-6F201EFA-43A0-4D10-B1D1-9D7F84AA3446

P1476

Q33395687-67CFFA18-10F0-4397-B94A-2A1B7B6FB06A

P2093

Q33395687-161D803B-FE54-48D2-B12B-437E6666E344

Q33395687-173B416B-F4ED-474C-9064-CDAAF443CFC6

Q33395687-1FDE7756-CA16-4573-B616-30F923662F46

Q33395687-276DF71E-E79F-48E5-800F-B38B2438AFD5

Q33395687-4CF890EF-973B-4919-A2C1-BAC598CA42E8

Q33395687-C6E4E826-5139-4F85-8B17-1DBE06FF61F4

P2860

Q33395687-02AC37AD-77D6-4BF9-8A34-1D09DBED280D

Q33395687-08D2DE27-CA61-4D1F-B3D1-67505381B9E7

Q33395687-1FB9C37A-5A1D-487F-96AD-BCDC811F9F08

Q33395687-215CDB98-31B4-4385-9ED6-E89F1172762B

Q33395687-2C9106DB-F003-4979-BEC8-97D7717D81EF

Q33395687-317BE6B1-81D6-4773-8D54-582A1056CAD1

Q33395687-3686D558-B1E1-4E1F-892C-6D0313719594

Q33395687-499CA9A1-9B67-4929-81B2-AA703C3E5896

Q33395687-4A3EAE40-25C3-4BE2-BFCD-F825E6CDD958

Q33395687-50ADCAF0-48F4-46B3-BC94-A37399D36D62

P304

Q33395687-BD74DDE6-04E8-4432-B843-4B548AB33DEC

P31

Q33395687-40AFB80E-0179-4703-9CD6-FB814F6FAD11

P356

Q33395687-028E2313-E0B8-4D19-B610-E4ABA7B2800E

P407

Q33395687-344CD89C-44FA-4A80-896B-43D0F59D9684

P433

Q33395687-7A80DF0B-F3B8-4503-9935-A740D7337D86

P478

Q33395687-E1C62C92-4B0E-4081-A1D2-A1C8CF8D4DFE

P50

Q33395687-1E1FDE06-98C7-41A5-AD0F-EA66EA2AC22A

P577

Q33395687-E3F4EC16-3ADF-4AEF-9A4B-7D58718C0DCA

P5875

Q33395687-3BB75902-2EAE-44D0-B234-959DC67A1802

P698

Q33395687-3BC84E60-A94C-45F5-A865-FBA81A16B181

P921

Q33395687-1E7F2C80-709F-491D-8967-09F648BEB402

Q33395687-F3557839-CC4B-45CA-BC91-DF0BDC27EA9F

P932

Q33395687-8A440751-34A9-49AC-9912-9A91D1FD1E68

P356

BLOOD-2011-03-342352

P1433

P1476

CalDAG-GEFI deficiency protect ...... rombosis and thrombocytopenia.

@en

P2093

Michael P Reilly

http://www.w3.org/2001/XMLSchema#string

Moritz Stolla

http://www.w3.org/2001/XMLSchema#string

Pierrette André

http://www.w3.org/2001/XMLSchema#string

Steven E McKenzie

http://www.w3.org/2001/XMLSchema#string

Timothy D Ouellette

http://www.w3.org/2001/XMLSchema#string

Wolfgang Bergmeier

http://www.w3.org/2001/XMLSchema#string

P2860

CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation

Immune heparin-induced thrombocytopenia can occur in patients receiving clopidogrel and aspirin

The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen

Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III.

The kinetics of αIIbβ3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy.

The role of the human Fc receptor Fc gamma RIIA in the immune clearance of platelets: a transgenic mouse model.

Structural and functional characterization of the mouse von Willebrand factor receptor GPIb-IX with novel monoclonal antibodies.

Identification of critical antigen-specific mechanisms in the development of immune thrombocytopenic purpura in mice.

Thrombosis and shock induced by activating antiplatelet antibodies in human Fc gamma RIIA transgenic mice: the interplay among antibody, spleen, and Fc receptor.

Heparin-induced thrombocytopenia/thrombosis in a transgenic mouse model requires human platelet factor 4 and platelet activation through FcgammaRIIA.

P304

1113-1120

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1182/BLOOD-2011-03-342352

http://www.w3.org/2001/XMLSchema#string

P407

P433

4

http://www.w3.org/2001/XMLSchema#string

P478

118

http://www.w3.org/2001/XMLSchema#string

P50

Lucia Stefanini

P577

2011-06-07T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

51201245

http://www.w3.org/2001/XMLSchema#string

P698

21652673

http://www.w3.org/2001/XMLSchema#string

P921

thrombocytopenia

P932

3148161

http://www.w3.org/2001/XMLSchema#string