Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility.
about
High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinaseAn evolutionary perspective on the kinome of malaria parasitesRecent developments in drug discovery for leishmaniasis and human African trypanosomiasisUsing genetic methods to define the targets of compounds with antimalarial activityThe calcium signaling toolkit of the Apicomplexan parasites Toxoplasma gondii and Plasmodium sppPhosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion.A cyclic GMP signalling module that regulates gliding motility in a malaria parasiteAn essential malaria protein defines the architecture of blood-stage and transmission-stage parasites.TgCDPK3 regulates calcium-dependent egress of Toxoplasma gondii from host cellsRegulation of the Plasmodium Motor Complex: PHOSPHORYLATION OF MYOSIN A TAIL-INTERACTING PROTEIN (MTIP) LOOSENS ITS GRIP ON MyoAThe Cryptosporidium parvum KinomeDevelopment of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoesEffects of calcium signaling on Plasmodium falciparum erythrocyte invasion and post-translational modification of gliding-associated protein 45 (PfGAP45)Rab11A-controlled assembly of the inner membrane complex is required for completion of apicomplexan cytokinesisAssay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90Identification of Toxoplasma gondii cAMP dependent protein kinase and its role in the tachyzoite growthA forward genetic screen reveals that calcium-dependent protein kinase 3 regulates egress in ToxoplasmaBiochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active CompoundsA plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytesInhibition of Plasmodium falciparum CDPK1 by conditional expression of its J-domain demonstrates a key role in schizont developmentBiochemical and antiparasitic properties of inhibitors of the Plasmodium falciparum calcium-dependent protein kinase PfCDPK1Dissection of mechanisms involved in the regulation of Plasmodium falciparum calcium-dependent protein kinase 4A DOC2 protein identified by mutational profiling is essential for apicomplexan parasite exocytosisA high-throughput phenotypic screen identifies clofazimine as a potential treatment for cryptosporidiosisUsing small molecules to dissect mechanisms of microbial pathogenesis.The malaria parasite cyclic GMP-dependent protein kinase plays a central role in blood-stage schizogony.Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence.Optimization of an imidazopyridazine series of inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1).Identification of inhibitors for putative malaria drug targets among novel antimalarial compounds.A research agenda for malaria eradication: basic science and enabling technologiesUse of the kinase inhibitor analog 1NM-PP1 reveals a role for Toxoplasma gondii CDPK1 in the invasion step.PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum.Screening and hit evaluation of a chemical library against blood-stage Plasmodium falciparum.Expanding the Antimalarial Drug Arsenal-Now, But How?Quantitative in vivo analyses reveal calcium-dependent phosphorylation sites and identifies a novel component of the Toxoplasma invasion motor complexHow apicomplexan parasites move in and out of cells.Regulation of Plasmodium falciparum glideosome associated protein 45 (PfGAP45) phosphorylationImidazolopiperazines: lead optimization of the second-generation antimalarial agents.The systematic functional analysis of Plasmodium protein kinases identifies essential regulators of mosquito transmissionSelective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin
P2860
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P2860
Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility.
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Gene expression signatures and ...... lasmodium falciparum motility.
@ast
Gene expression signatures and ...... lasmodium falciparum motility.
@en
Gene expression signatures and ...... lasmodium falciparum motility.
@nl
type
label
Gene expression signatures and ...... lasmodium falciparum motility.
@ast
Gene expression signatures and ...... lasmodium falciparum motility.
@en
Gene expression signatures and ...... lasmodium falciparum motility.
@nl
prefLabel
Gene expression signatures and ...... lasmodium falciparum motility.
@ast
Gene expression signatures and ...... lasmodium falciparum motility.
@en
Gene expression signatures and ...... lasmodium falciparum motility.
@nl
P2093
P50
P356
P1476
Gene expression signatures and ...... lasmodium falciparum motility.
@en
P2093
Advait Nagle
Arnab Chatterjee
Badry Bursulaya
Carsten Andersen
Case McNamara
Daniel Mason
David Plouffe
Eric C Peters
Felix Marr
Jeffrey Harper
P2888
P304
P356
10.1038/NCHEMBIO.87
P577
2008-05-04T00:00:00Z