Antithrombotic effect of platelet glycoprotein Ib-blocking monoclonal antibody Fab fragments in nonhuman primates.
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P1343
Four-dimensional characterization of thrombosis in a live-cell, shear-flow assay: development and application to xenotransplantationMapping paratope on antithrombotic antibody 6B4 to epitope on platelet glycoprotein Ibalpha via molecular dynamic simulationsPharmacological characterization and antithrombotic effect of agkistin, a platelet glycoprotein Ib antagonistAnticalins as an alternative to antibody technology.Functional display of platelet-binding VWF fragments on filamentous bacteriophageFunction-modulating human monoclonal antibodies against platelet-membrane receptors isolated from a phage-display library.ADAMTS-13 plasma level determination uncovers antigen absence in acquired thrombotic thrombocytopenic purpura and ethnic differences.Microparticles adhere to collagen type I, fibrinogen, von Willebrand factor and surface immobilised platelets at physiological shear rates.Pig-to-baboon liver xenoperfusion utilizing GalTKO.hCD46 pigs and glycoprotein Ib blockade.Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopeniaDimerization of glycoprotein Ibα is not sufficient to induce platelet clearance.The chimeric monoclonal antibody MHCSZ-123 against human von Willebrand factor A3 domain inhibits high-shear arterial thrombosis in a Rhesus monkey modelvon Willebrand factor: an emerging target in stroke therapy.Identification of a small molecule that modulates platelet glycoprotein Ib-von Willebrand factor interactionDelineating the roles of the GPIIb/IIIa and GP-Ib-IX-V platelet receptors in mediating platelet adhesion to adsorbed fibrinogen and albumin.Novel agents for anti-platelet therapy.Linker regions and flexibility around the metalloprotease domain account for conformational activation of ADAMTS-13.Future innovations in anti-platelet therapies.Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor.Validation of the human tissue factor/FVIIa complex as an antithrombotic target and the discovery of a synthetic peptide.Ischaemic stroke: a thrombo-inflammatory disease?Platelet adhesion and activation mechanisms in arterial thrombosis and ischaemic stroke.Targeting von Willebrand factor as a novel anti-platelet therapy; application of ARC1779, an Anti-vWF aptamer, against thrombotic risk.Potential value of targeting von Willebrand factor in atherosclerotic cardiovascular disease.The role of platelets in coagulation dysfunction in xenotransplantation, and therapeutic options.Two novel monoclonal antibodies to VWFA3 inhibit VWF-collagen and VWF-platelet interactions.Comparison of common platelet receptors between the chacma baboon (Papio ursinus) and human for use in pre-clinical human-targeted anti-platelet studies.Identification of a VWF peptide antagonist that blocks platelet adhesion under high shear conditions by selectively inhibiting the VWF-collagen interaction.Antiplatelet therapy: present status and future prospects.Rhodocytin (aggretin) activates platelets lacking alpha(2)beta(1) integrin, glycoprotein VI, and the ligand-binding domain of glycoprotein Ibalpha.The Cape Chacma baboon is not suitable for evaluating human targeted anti-GPVI agents.Paratope determination of the antithrombotic antibody 82D6A3 based on the crystal structure of its complex with the von Willebrand factor A3-domain.Fc-independent immune thrombocytopenia via mechanomolecular signaling in platelets.The type 2B p.R1306W natural mutation of von Willebrand factor dramatically enhances the multimer sensitivity to shear stress.Mutant botrocetin-2 inhibits von Willebrand factor-induced platelet agglutination.Mechanisms of platelet clearance and translation to improve platelet storage.Antiplatelet drugsParatope and Epitope Mapping of the Antithrombotic Antibody 6B4 in Complex with Platelet Glycoprotein IbαNovel antibodies against GPIbα inhibit pulmonary metastasis by affecting vWF-GPIbα interaction
P2860
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P2860
Antithrombotic effect of platelet glycoprotein Ib-blocking monoclonal antibody Fab fragments in nonhuman primates.
description
2000 nî lūn-bûn
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2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2000 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Antithrombotic effect of plate ...... ragments in nonhuman primates.
@ast
Antithrombotic effect of plate ...... ragments in nonhuman primates.
@en
Antithrombotic effect of plate ...... ragments in nonhuman primates.
@nl
type
label
Antithrombotic effect of plate ...... ragments in nonhuman primates.
@ast
Antithrombotic effect of plate ...... ragments in nonhuman primates.
@en
Antithrombotic effect of plate ...... ragments in nonhuman primates.
@nl
prefLabel
Antithrombotic effect of plate ...... ragments in nonhuman primates.
@ast
Antithrombotic effect of plate ...... ragments in nonhuman primates.
@en
Antithrombotic effect of plate ...... ragments in nonhuman primates.
@nl
P2093
P356
P1476
Antithrombotic effect of plate ...... fragments in nonhuman primates
@en
P2093
N Cauwenberghs
S Lamprecht
S Vauterin
P304
P356
10.1161/01.ATV.20.5.1347
P407
P4510
P577
2000-05-01T00:00:00Z