Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins. - Wikidata - wikimedia - TriplyDB

Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins.

Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins.

http://www.wikidata.org/entity/Q33345150

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Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins Inhibition of Bfl-1 with N-aryl maleimides.Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1 Evaluation of the pharmacophoric motif of the caged Garcinia xanthones High-throughput fluorescence polarization assay for chemical library screening against anti-apoptotic Bcl-2 family member Bfl-1.The synthetic caged garcinia xanthone cluvenone induces cell stress and apoptosis and has immune modulatory activity.Methyl jasmonate sensitizes human bladder cancer cells to gambogic acid-induced apoptosis through down-regulation of EZH2 expression by miR-101.Chemistry and biology of the caged Garcinia xanthones.Anti-cancer natural products isolated from chinese medicinal herbs The mitochondrial death pathway: a promising therapeutic target in diseases Recent research on bioactive xanthones from natural medicine: Garcinia hanburyi.Subcellular localization and activity of gambogic acid Inhibition of inwardly rectifying Kir2.x channels by the novel anti-cancer agent gambogic acid depends on both pore block and PIP2 interference.A-ring oxygenation modulates the chemistry and bioactivity of caged Garcinia xanthones.Gambogic acid enhances proteasome inhibitor-induced anticancer activity.Gambogic acid induces apoptosis in diffuse large B-cell lymphoma cells via inducing proteasome inhibition Synergetic effect of functional cadmium-tellurium quantum dots conjugated with gambogic acid for HepG2 cell-labeling and proliferation inhibition Tumor neovasculature-targeted cationic PEGylated liposomes of gambogic acid for the treatment of triple-negative breast cancer Novel Natural Product-like Caged Xanthones Bearing a Carbamate Moiety Exhibit Antitumor Potency and Anti-Angiogenesis Activity In vivo.BCL2A1: the underdog in the BCL2 family.Anti-leukemic, anti-lung, and anti-breast cancer potential of the microbial polyketide 2, 4-diacetylphloroglucinol (DAPG) and its interaction with the metastatic proteins than the antiapoptotic Bcl-2 proteins.Gambogic Acid and Its Role in Chronic Diseases.Natural compounds with P2X7 receptor-modulating properties.Gambogic acid promotes apoptosis and resistance to metastatic potential in MDA-MB-231 human breast carcinoma cells.Gambogic acid as a non-competitive inhibitor of ATP-binding cassette transporter B1 reverses the multidrug resistance of human epithelial cancers by promoting ATP-binding cassette transporter B1 protein degradation.Antitumor effects of novel compound, guttiferone K, on colon cancer by p21Waf1/Cip1-mediated G(0) /G(1) cell cycle arrest and apoptosis.Cluvenone induces apoptosis via a direct target in mitochondria: a possible mechanism to circumvent chemo-resistance?Direct visualization of Bcl-2 family protein interactions using live cell fluorescent protein redistribution assays.Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system.Folate-decorated arginine-based poly(ester urea urethane) nanoparticles as carriers for gambogic acid and effect on cancer cells.General pharmacological properties, developmental toxicity, and analgesic activity of gambogic acid, a novel natural anticancer agent.MCL-1 inhibition in cancer treatment

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P2860

Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins.

http://www.wikidata.org/entity/Q33345150

description

2008 nî lūn-bûn

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2008 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2008 թվականի հունիսին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins.

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Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins.

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type

label

Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins.

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Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins.

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prefLabel

Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins.

@ast

Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins.

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1535-7163.MCT-07-2373

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Molecular Cancer Therapeutics

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Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins.

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Arnold C Satterthwait

http://www.w3.org/2001/XMLSchema#string

Chaofang Jin

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Chung-Wai Shiau

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Dayong Zhai

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John C Reed

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Shinichi Kitada

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P2860

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

Cytoprotective peptide humanin binds and inhibits proapoptotic Bcl-2/Bax family protein BimEL

A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid

Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB signaling pathway

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

Humanin binds and nullifies Bid activity by blocking its activation of Bax and Bak

Mitochondrial activation of apoptosis

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

The Bcl2 family: regulators of the cellular life-or-death switch

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1639-1646

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10.1158/1535-7163.MCT-07-2373

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6

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18566235

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2614397

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