Binding to the minor groove of the double-strand, tau protein prevents DNA from damage by peroxidation.
about
Nuclear Tau and Its Potential Role in Alzheimer's DiseaseFrontotemporal lobar degeneration: old knowledge and new insight into the pathogenetic mechanisms of tau mutationsNuclear tau, a key player in neuronal DNA protection.Variations in brain DNATau deficiency leads to the upregulation of BAF-57, a protein involved in neuron-specific gene repressionThe proline-rich domain of tau plays a role in interactions with actin.Tau promotes neurodegeneration through global chromatin relaxation.A major role for Tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditionsProfiling murine tau with 0N, 1N and 2N isoform-specific antibodies in brain and peripheral organs reveals distinct subcellular localization, with the 1N isoform being enriched in the nucleus.Thermodynamics of the interaction between Alzheimer's disease related tau protein and DNAFunctional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation.Using intramolecular disulfide bonds in tau protein to deduce structural features of aggregation-resistant conformations.Amyloid Precursor Protein (APP) Metabolites APP Intracellular Fragment (AICD), Aβ42, and Tau in Nuclear Roles.Loss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatinMultimerization and DNA binding properties of INI1/hSNF5 and its functional significance.Shaping of interphase chromosomes by the microtubule network.Mutations in MAPT give rise to aneuploidy in animal models of tauopathy.Visualizing the microtubule-associated protein tau in the nucleus.A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies.Pathological implications of nucleic acid interactions with proteins associated with neurodegenerative diseasesProtein phosphatase 2A and tau: an orchestrated 'Pas de Deux'.Altered Machinery of Protein Synthesis in Alzheimer's: From the Nucleolus to the Ribosome.Genome instability in Alzheimer disease.Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activatorHyperphosphorylation of Tau Associates With Changes in Its Function Beyond Microtubule Stability
P2860
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P2860
Binding to the minor groove of the double-strand, tau protein prevents DNA from damage by peroxidation.
description
2008 nî lūn-bûn
@nan
2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
name
Binding to the minor groove of ...... A from damage by peroxidation.
@ast
Binding to the minor groove of ...... A from damage by peroxidation.
@en
type
label
Binding to the minor groove of ...... A from damage by peroxidation.
@ast
Binding to the minor groove of ...... A from damage by peroxidation.
@en
prefLabel
Binding to the minor groove of ...... A from damage by peroxidation.
@ast
Binding to the minor groove of ...... A from damage by peroxidation.
@en
P2093
P2860
P1433
P1476
Binding to the minor groove of ...... A from damage by peroxidation.
@en
P2093
Dong-Liang Wang
Mei-Hua Qu
Rong-Qiao He
Xing-Sheng Wang
P2860
P356
10.1371/JOURNAL.PONE.0002600
P407
P50
P577
2008-07-02T00:00:00Z