The WldS gene delays axonal but not somatic degeneration in a rat glaucoma model.
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Laser-based single-axon transection for high-content axon injury and regeneration studiesCritical pathogenic events underlying progression of neurodegeneration in glaucomaSustained ocular hypertension induces dendritic degeneration of mouse retinal ganglion cells that depends on cell type and location.NAD+ and SIRT3 control microtubule dynamics and reduce susceptibility to antimicrotubule agents.Wallerian-like axonal degeneration in the optic nerve after excitotoxic retinal insult: an ultrastructural study.Rodent models of glaucoma.Overexpression of Wld(S) or Nmnat2 in mauthner cells by single-cell electroporation delays axon degeneration in live zebrafish.DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injuryRapid in vivo forward genetic approach for identifying axon death genes in DrosophilaWallerian degeneration, wld(s), and nmnat.Retrograde and Wallerian axonal degeneration occur synchronously after retinal ganglion cell axotomy.Retinal ganglion cell survival and axon regeneration in WldS transgenic rats after optic nerve crush and lens injury.Synaptic protection in the brain of WldS mice occurs independently of age but is sensitive to gene-dose.Identification of palmitoyltransferase and thioesterase enzymes that control the subcellular localization of axon survival factor nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2)Use of an adult rat retinal explant model for screening of potential retinal ganglion cell neuroprotective therapies.Axonal transport declines with age in two distinct phases separated by a period of relative stability.Optic neuritis and retinal ganglion cell loss in a chronic murine model of multiple sclerosis.Systemic adeno-associated virus-mediated gene therapy preserves retinal ganglion cells and visual function in DBA/2J glaucomatous miceEnhanced Retinal Ganglion Cell Survival in Glaucoma by Hypoxic Postconditioning After Disease Onset.Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death.Time-Lapse Retinal Ganglion Cell Dendritic Field Degeneration Imaged in Organotypic Retinal Explant CultureThe Apoptotic Engulfment Machinery Regulates Axonal Degeneration in C. elegans Neurons.Dose-dependent treatment of optic nerve crush by exogenous systemic mutant erythropoietinProtection of mouse retinal ganglion cell axons and soma from glaucomatous and ischemic injury by cytoplasmic overexpression of Nmnat1.Molecular chaperones protect against JNK- and Nmnat-regulated axon degeneration in DrosophilaRescuing axons from degeneration does not affect retinal ganglion cell death.Excitotoxicity upregulates SARM1 protein expression and promotes Wallerian-like degeneration of retinal ganglion cells and their axons.Rescue of Glaucomatous Neurodegeneration by Differentially Modulating Neuronal Endoplasmic Reticulum Stress Molecules.Role of hypoxia-inducible factor-1α in preconditioning-induced protection of retinal ganglion cells in glaucoma.NMNATs, evolutionarily conserved neuronal maintenance factors.Axon degeneration is key component of neuronal death in amyloid-β toxicity.The cell and molecular biology of glaucoma: mechanisms of retinal ganglion cell death.Pathophysiology of human glaucomatous optic nerve damage: insights from rodent models of glaucoma.Wld(S), Nmnats and axon degeneration--progress in the past two decades.Intrinsic axonal degeneration pathways are critical for glaucomatous damage.Axonal degeneration as a therapeutic target in the CNS.Review: Axon pathology in age-related neurodegenerative disorders.Concepts for regulation of axon integrity by enwrapping glia.Wallerian degeneration: an emerging axon death pathway linking injury and disease.Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism.
P2860
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P2860
The WldS gene delays axonal but not somatic degeneration in a rat glaucoma model.
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
name
The WldS gene delays axonal but not somatic degeneration in a rat glaucoma model.
@ast
The WldS gene delays axonal but not somatic degeneration in a rat glaucoma model.
@en
type
label
The WldS gene delays axonal but not somatic degeneration in a rat glaucoma model.
@ast
The WldS gene delays axonal but not somatic degeneration in a rat glaucoma model.
@en
prefLabel
The WldS gene delays axonal but not somatic degeneration in a rat glaucoma model.
@ast
The WldS gene delays axonal but not somatic degeneration in a rat glaucoma model.
@en
P2093
P1476
The WldS gene delays axonal but not somatic degeneration in a rat glaucoma model.
@en
P2093
Bogdan Beirowski
Elisabetta Babetto
Keith R Martin
Michael P Coleman
P2860
P304
P356
10.1111/J.1460-9568.2008.06426.X
P407
P577
2008-09-09T00:00:00Z