Multiple innate inflammatory responses induced after systemic adenovirus vector delivery depend on a functional complement system.
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A Four-Biomarker Blood Signature Discriminates Systemic Inflammation Due to Viral Infection Versus Other Etiologies.Complex interactions with several arms of the complement system dictate innate and humoral immunity to adenoviral vectors.Transient pretreatment with glucocorticoid ablates innate toxicity of systemically delivered adenoviral vectors without reducing efficacy.Analysis of adenoviral attachment to human platelets.Adenovirus capsid-display of the retro-oriented human complement inhibitor DAF reduces Ad vector-triggered immune responses in vitro and in vivo.Adenoviral vector immunity: its implications and circumvention strategies.The in vivo therapeutic efficacy of the oncolytic adenovirus Delta24-RGD is mediated by tumor-specific immunityCR1/2 is an important suppressor of Adenovirus-induced innate immune responses and is required for induction of neutralizing antibodiesHepatic gene transfer as a means of tolerance induction to transgene productsTRIF, and TRIF-interacting TLRs differentially modulate several adenovirus vector-induced immune responses.Gene therapy for monogenic liver diseases: clinical successes, current challenges and future prospects.beta-Arrestins modulate Adenovirus-vector-induced innate immune responses: differential regulation by beta-arrestin-1 and beta-arrestin-2.Novel adenovirus vectors 'capsid-displaying' a human complement inhibitor.Generation of a cholangiocyte-specific cDNA expression library for the identification of B and T cell autoantigens in murine biliary disease.Catheter-based intramyocardial delivery (NavX) of adenovirus achieves safe and accurate gene transfer in pigs.Clearance of adenovirus by Kupffer cells is mediated by scavenger receptors, natural antibodies, and complementAdenovirus vector induced innate immune responses: impact upon efficacy and toxicity in gene therapy and vaccine applications.Helper-dependent adenoviral vectors for liver-directed gene therapy.IL-1α and complement cooperate in triggering local neutrophilic inflammation in response to adenovirus and eliminating virus-containing cellsUse of DAF-displaying adenovirus vectors reduces induction of transgene- and vector-specific adaptive immune responses in mice.Enhancing the therapeutic efficacy of adenovirus in combination with biomaterials.Adenovirus infection triggers a rapid, MyD88-regulated transcriptome response critical to acute-phase and adaptive immune responses in vivoInnate immune response to adenoviral vectors is mediated by both Toll-like receptor-dependent and -independent pathways.Current advances and future challenges in Adenoviral vector biology and targetingComplement is an essential component of the immune response to adeno-associated virus vectors.Progress and problems when considering gene therapy for GSD-II.Adenovirus activates complement by distinctly different mechanisms in vitro and in vivo: indirect complement activation by virions in vivo.Adenovirus Vector-Derived VA-RNA-Mediated Innate Immune Responses.Strategies to overcome host immunity to adenovirus vectors in vaccine development.Helper-Dependent Adenoviral Vectors.Gene therapy with helper-dependent adenoviral vectors: current advances and future perspectives.Improving adenovirus based gene transfer: strategies to accomplish immune evasion.Manipulation of adenovirus interactions with host factors for gene therapy applications.Immune recognition of gene transfer vectors: focus on adenovirus as a paradigm.The evolution of adenoviral vectors through genetic and chemical surface modifications.The importance of coagulation factors binding to adenovirus: historical perspectives and implications for gene delivery.Tropism-modification strategies for targeted gene delivery using adenoviral vectors.Potential usefulness of baculovirus-mediated sodium-iodide symporter reporter gene as non-invasively gene therapy monitoring in liver cancer cells: an in vitro evaluation.Replication-attenuated Human Adenoviral Type 4 vectors elicit capsid dependent enhanced innate immune responses that are partially dependent upon interactions with the complement system.Gene Therapy in the Nervous System: Failures and Successes.
P2860
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P2860
Multiple innate inflammatory responses induced after systemic adenovirus vector delivery depend on a functional complement system.
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Multiple innate inflammatory r ...... functional complement system.
@ast
Multiple innate inflammatory r ...... functional complement system.
@en
type
label
Multiple innate inflammatory r ...... functional complement system.
@ast
Multiple innate inflammatory r ...... functional complement system.
@en
prefLabel
Multiple innate inflammatory r ...... functional complement system.
@ast
Multiple innate inflammatory r ...... functional complement system.
@en
P2093
P1433
P1476
Multiple innate inflammatory r ...... a functional complement system
@en
P2093
Andrea Amalfitano
Anne Kiang
Delila Serra
Haixiang Jiang
Michael M Frank
Zachary C Hartman
P304
P356
10.1016/J.YMTHE.2006.03.024
P50
P577
2006-06-02T00:00:00Z