The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend.
about
Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation.Integrin-based therapeutics: biological basis, clinical use and new drugsSwing-out of the β3 hybrid domain is required for αIIbβ3 priming and normal cytoskeletal reorganization, but not adhesion to immobilized fibrinogenClosed headpiece of integrin IIb 3 and its complex with an IIb 3-specific antagonist that does not induce openingStructure-Guided Design of a High-Affinity Platelet Integrin IIb 3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDASPhosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces.The kinetics of αIIbβ3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy.Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin αIIbβ3 in miceOutside-in signalling generated by a constitutively activated integrin αIIbβ3 impairs proplatelet formation in human megakaryocytes.WASP plays a novel role in regulating platelet responses dependent on alphaIIbbeta3 integrin outside-in signallingPathogenic hantaviruses direct the adherence of quiescent platelets to infected endothelial cells.Inherited platelet disorders: a clinical approach to diagnosis and management.Hypoxia induces permeability and giant cell responses of Andes virus-infected pulmonary endothelial cells by activating the mTOR-S6K signaling pathway.Congenital platelet disorders and understanding of platelet function.Effect of steroids on the activation status of platelets in patients with Immune thrombocytopenia (ITP).Platelets and infection - an emerging role of platelets in viral infection.Endothelial cell dysfunction in viral hemorrhage and edema.αIIbβ3 variants defined by next-generation sequencing: predicting variants likely to cause Glanzmann thrombasthenia.Thrombocytopenia in Dengue: Interrelationship between Virus and the Imbalance between Coagulation and Fibrinolysis and Inflammatory Mediators.Proteomic and phospho-proteomic profile of human platelets in basal, resting state: insights into integrin signaling.Andes virus recognition of human and Syrian hamster beta3 integrins is determined by an L33P substitution in the PSI domain.Glanzmann thrombasthenia: state of the art and future directions.Pannexin- and Connexin-Mediated Intercellular Communication in Platelet Function.What is vinculin needed for in platelets?Hantavirus interferon regulation and virulence determinantsCystine-knot peptides engineered with specificities for α(IIb)β(3) or α(IIb)β(3) and α(v)β(3) integrins are potent inhibitors of platelet aggregation.HPW-RX40 prevents human platelet activation by attenuating cell surface protein disulfide isomerases.Humanized mouse model of thrombosis is predictive of the clinical efficacy of antiplatelet agents.Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living miceIn vivo imaging analysis of the interaction between unusually large von Willebrand factor multimers and platelets on the surface of vascular wall.The importance of N-glycosylation on β3 integrin ligand binding and conformational regulationTraversing the valley of death: a guide to assessing prospects for translational successIntegrin αII b tail distal of GFFKR participates in inside-out αII b β3 activation.Pathogenic hantaviruses Andes virus and Hantaan virus induce adherens junction disassembly by directing vascular endothelial cadherin internalization in human endothelial cellsBasal release of ATP: an autocrine-paracrine mechanism for cell regulation.The final steps of integrin activation: the end gameThe platelet: life on the razor's edge between hemorrhage and thrombosis.Vinculin is indispensable for repopulation by hematopoietic stem cells, independent of integrin function.Direct interaction of kindlin-3 with integrin αIIbβ3 in platelets is required for supporting arterial thrombosis in mice.Modulation of integrin activation by an entropic spring in the {beta}-knee
P2860
Q24313629-2335162C-DFD4-42FB-A4BB-7C8DE01301E1Q26773026-CBC0FDA4-BCDC-4160-8783-FCE7D8C0C011Q27301036-EF69F341-316B-494B-B7C4-5A41AA0635B4Q27663824-BFA3E402-59E1-43F5-A94D-9482EDAC640BQ27678064-747EDADB-50C7-40D2-A792-067905207014Q30492793-35924426-AC83-4F9A-A948-0F60538A7A27Q30498119-CA4E45D7-7227-4ADC-94AF-59CD238AA937Q30572399-EE916599-BB7D-4B16-9EB5-C982C6729743Q31059222-5287EB4A-BE16-45C0-B389-59687F83C49BQ33386825-968C1FEA-C015-4C03-80F2-35A000E4B9E4Q33388382-C59C9BA8-C241-45DF-9E19-85C96534C8E6Q33396427-CFF826F8-6A38-472E-A05B-77E260A982F1Q33410566-EE2209D0-C85E-4BD2-A1DF-48C1BF5E0519Q33411778-074B711B-1442-47F2-8FC1-9802D59A2FADQ33413853-1B57DEAA-0708-4E68-94B6-74B8F23F54ECQ33419642-6718FF11-CBA5-4927-86E4-EDDAD605BBCAQ33419868-D5E7B9E9-2E37-4951-9074-1F8E7275D5BAQ33421611-C5273432-B62F-49EB-83A1-70C36A5C4CD7Q33423030-496CAEC0-DC4B-4DC9-B817-74D7BFF05970Q33512916-DD77ED1C-36DD-4264-A3ED-C267668BC299Q33558721-8B202D47-DE59-4929-B060-8A9AC119558FQ33571529-652552B0-93AD-4D7C-A8FD-A55D8CEF9A29Q33624852-4E0A4BD6-B9A2-4055-BAA5-FD885BF2E425Q33644890-06BBCA7F-AFD4-40EC-8E52-D0A39709E431Q33758371-8F69DE10-DD99-4C22-86D3-28F1CD0DC5AAQ33782671-AB18739F-A34A-4D78-94FD-01F9FC3FAF40Q33784320-6BC674B6-78B0-4CC4-A0EE-75D0924C4F5DQ33789829-B8B93762-84A1-4AC2-B443-F1AF6F9B11FFQ33789872-D8B16A3E-6052-47BF-97FB-8FAC06206266Q33873826-CA7DE3F5-492B-4157-9EEC-C4D8275E20D9Q33875329-1F56A75A-FBCF-44EF-879A-EA326A118B11Q33887728-CE165FE8-A596-48BC-9972-D99530C3D4DBQ33934753-8D79C4B9-0F1C-4B81-A61D-80356447E2CFQ33966683-CD2D4B1D-A02D-4A2D-8AEC-AAFE9DFFD8A2Q34020834-6E972D6F-CFB7-4A6B-A36F-7D7052F0E32EQ34106011-99B5F798-D3CF-42A8-9822-3188D653FD9CQ34175105-B2458ADA-3070-4FFD-AAAC-42BEBEF1EFF2Q34181566-E7A01F58-DBF1-434F-93C7-7C7035F71621Q34204496-7B98C606-0F27-40F9-BC13-D0AFADF86BBFQ34236673-C90E71F4-FFEC-48E4-976E-2BEFBD562D88
P2860
The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend.
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
The GPIIb/IIIa (integrin alpha ...... wists, turns, and even a bend.
@ast
The GPIIb/IIIa (integrin alpha ...... wists, turns, and even a bend.
@en
type
label
The GPIIb/IIIa (integrin alpha ...... wists, turns, and even a bend.
@ast
The GPIIb/IIIa (integrin alpha ...... wists, turns, and even a bend.
@en
prefLabel
The GPIIb/IIIa (integrin alpha ...... wists, turns, and even a bend.
@ast
The GPIIb/IIIa (integrin alpha ...... wists, turns, and even a bend.
@en
P2860
P1433
P1476
The GPIIb/IIIa (integrin alpha ...... wists, turns, and even a bend.
@en
P2093
Barry S Coller
Sanford J Shattil
P2860
P304
P356
10.1182/BLOOD-2008-06-077891
P407
P577
2008-10-01T00:00:00Z