Eptifibatide-induced thrombocytopenia and thrombosis in humans require FcgammaRIIa and the integrin beta3 cytoplasmic domain.
about
Structural basis for pure antagonism of integrin αVβ3 by a high-affinity form of fibronectinClosed headpiece of integrin IIb 3 and its complex with an IIb 3-specific antagonist that does not induce openingStructure-Guided Design of a High-Affinity Platelet Integrin IIb 3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDASAnti-thrombotic agents derived from snake venom proteinsCooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo.Small molecule agonists of integrin CD11b/CD18 do not induce global conformational changes and are significantly better than activating antibodies in reducing vascular injury.Drug-induced thrombocytopenia: pathogenesis, evaluation, and management.Left main stent thrombosis complicated by eptifibatide-induced acute thrombocytopeniaProfound thrombocytopenia after primary exposure to eptifibatide.The Syk-kinase inhibitor R406 impairs platelet activation and monocyte tissue factor expression triggered by heparin-PF4 complex directed antibodies.Eptifibatide-induced thrombocytopenia: with thrombosis and disseminated intravascular coagulation immediately after left main coronary artery percutaneous coronary angioplasty.Paradoxical thrombosis, part 2: anticoagulant and antiplatelet therapy.A megakaryocyte with no platelets: anti-platelet antibodies, apoptosis, and platelet production.Approach to the diagnosis and management of drug-induced immune thrombocytopenia.Eptifibatide induced profound thrombocytopenia in a patient with pelvic malignancy: A case report.Human platelet IgG Fc receptor FcγRIIA in immunity and thrombosis.Eptifibatide-induced thrombocytopenia leading to acute stent thrombosis.Suppression of skin and kidney disease by inhibition of spleen tyrosine kinase in lupus-prone miceCurrent and novel therapeutics in the treatment of systemic lupus erythematosusHeparin promotes platelet responsiveness by potentiating αIIbβ3-mediated outside-in signaling.Clopidogrel Enhances Mesenchymal Stem Cell Proliferation Following Periodontitis.The pyrrolidinoindoline alkaloid Psm2 inhibits platelet aggregation and thrombus formation by affecting PI3K/Akt signalingFarnesoid X Receptor and Its Ligands Inhibit the Function of Platelets.Structural Basis for Simvastatin Competitive Antagonism of Complement Receptor 3.Disruption of integrin-fibronectin complexes by allosteric but not ligand-mimetic inhibitors.Lessons from recurrent deep vein thrombosis in Glanzmann thrombasthenia.An αIIb β3 antagonist prevents thrombosis without causing Fc receptor γ-chain IIa-mediated thrombocytopenia.A Case of Hyperacute Severe Thrombocytopenia Occurring Less than 24 Hours after Intravenous Tirofiban Infusion.
P2860
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P2860
Eptifibatide-induced thrombocytopenia and thrombosis in humans require FcgammaRIIa and the integrin beta3 cytoplasmic domain.
description
2009 nî lūn-bûn
@nan
2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Eptifibatide-induced thrombocy ...... grin beta3 cytoplasmic domain.
@ast
Eptifibatide-induced thrombocy ...... grin beta3 cytoplasmic domain.
@en
type
label
Eptifibatide-induced thrombocy ...... grin beta3 cytoplasmic domain.
@ast
Eptifibatide-induced thrombocy ...... grin beta3 cytoplasmic domain.
@en
prefLabel
Eptifibatide-induced thrombocy ...... grin beta3 cytoplasmic domain.
@ast
Eptifibatide-induced thrombocy ...... grin beta3 cytoplasmic domain.
@en
P2093
P2860
P356
P1476
Eptifibatide-induced thrombocy ...... grin beta3 cytoplasmic domain.
@en
P2093
Brian Boylan
Dan Bougie
Debra K Newman
Jessica Birenbaum
Joan C Gill
Peter J Newman
Richard H Aster
P2860
P304
P356
10.1172/JCI36745
P407
P577
2009-02-09T00:00:00Z