Integrins: dynamic scaffolds for adhesion and signaling in platelets
about
Glanzmann thrombastheniaHeadpiece domain of dematin regulates calcium mobilization and signaling in plateletsbeta-Dystroglycan modulates the interplay between actin and microtubules in human-adhered plateletsPTP-1B is an essential positive regulator of platelet integrin signalingDeadly allies: the fatal interplay between platelets and metastasizing cancer cellsThe small GTPase Rap1b regulates the cross talk between platelet integrin alpha2beta1 and integrin alphaIIbbeta3Platelet function and ageingPlatelet signalingSwing-out of the β3 hybrid domain is required for αIIbβ3 priming and normal cytoskeletal reorganization, but not adhesion to immobilized fibrinogenNormal Platelet Integrin Function in Mice Lacking Hydrogen Peroxide-Induced Clone-5 (Hic-5)Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functionsPlatelet function and pharmacologic inhibitionPlatelet integrin alpha(IIb)beta(3): activation mechanismsPlatelets induce apoptosis during sepsis in a contact-dependent manner that is inhibited by GPIIb/IIIa blockadePKCalpha regulates platelet granule secretion and thrombus formation in miceMegakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function.Forkhead box F1 is essential for migration of mesenchymal cells and directly induces integrin-beta3 expressionStructural basis of integrin regulation and signalingThe proline-rich tyrosine kinase Pyk2 regulates platelet integrin αIIbβ3 outside-in signaling.Matrix-specific suppression of integrin activation in shear stress signaling.Ligand density dramatically affects integrin alpha IIb beta 3-mediated platelet signaling and spreading.Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cellsLnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo.In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling.Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo.A directional switch of integrin signalling and a new anti-thrombotic strategy.Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin αIIbβ3 in miceDeubiquitinases Modulate Platelet Proteome Ubiquitination, Aggregation, and Thrombosis.Integrin alphaIIbbeta3:ligand interactions are linked to binding-site remodeling.Platelet fragmentation requires a specific structural conformation of human monoclonal antibody against beta3 integrin.A naturally occurring LeuVal mutation in beta3-integrin impairs the HPA-1a epitope: the third allele of HPA-1.The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend.Eptifibatide-induced thrombocytopenia and thrombosis in humans require FcgammaRIIa and the integrin beta3 cytoplasmic domain.A point mutation in the EGF-4 domain of β(3) integrin is responsible for the formation of the Sec(a) platelet alloantigen and affects receptor functionTargeting integrin and integrin signaling in treating thrombosis.Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopeniaPlatelet Activation and Thrombus Formation over IgG Immune Complexes Requires Integrin αIIbβ3 and Lyn Kinase.Immunodiagnosis of platelet activation in immune thrombocytopenia through scFv antibodies cognate to activated IIb3 integrinsAlloantibody against new platelet alloantigen (Lap(a)) on glycoprotein IIb is responsible for a case of fetal and neonatal alloimmune thrombocytopenia.Rapid characterization of hybridomas producing monoclonal antibodies against platelet β3 integrin using ELIspot.
P2860
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P2860
Integrins: dynamic scaffolds for adhesion and signaling in platelets
description
2004 nî lūn-bûn
@nan
2004 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Integrins: dynamic scaffolds for adhesion and signaling in platelets
@ast
Integrins: dynamic scaffolds for adhesion and signaling in platelets
@en
Integrins: dynamic scaffolds for adhesion and signaling in platelets
@nl
type
label
Integrins: dynamic scaffolds for adhesion and signaling in platelets
@ast
Integrins: dynamic scaffolds for adhesion and signaling in platelets
@en
Integrins: dynamic scaffolds for adhesion and signaling in platelets
@nl
prefLabel
Integrins: dynamic scaffolds for adhesion and signaling in platelets
@ast
Integrins: dynamic scaffolds for adhesion and signaling in platelets
@en
Integrins: dynamic scaffolds for adhesion and signaling in platelets
@nl
P3181
P1433
P1476
Integrins: dynamic scaffolds for adhesion and signaling in platelets
@en
P2093
Peter J Newman
Sanford J Shattil
P304
P3181
P356
10.1182/BLOOD-2004-04-1257
P407
P577
2004-09-15T00:00:00Z