Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains - Wikidata - wikimedia - TriplyDB

Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains

Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains

http://www.wikidata.org/entity/Q33385397

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Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size Positive feedback regulation of Akt-FMRP pathway protects neurons from cell death LPS-stimulating astrocyte-conditioned medium causes neuronal apoptosis via increasing CDK11(p58) expression in PC12 cells through downregulating AKT pathway Pdk1 activity controls proliferation, survival, and growth of developing pancreatic cells Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN.RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation Nuclear phosphoinositides: a signaling enigma wrapped in a compartmental conundrum.Ventromedial hypothalamus-specific Ptpn1 deletion exacerbates diet-induced obesity in female mice.mTOR signaling in glioblastoma: lessons learned from bench to bedside.Diet and energy-sensing inputs affect TorC1-mediated axon misrouting but not TorC2-directed synapse growth in a Drosophila model of tuberous sclerosis.The cerebrospinal fluid provides a proliferative niche for neural progenitor cells.Specific roles of Akt iso forms in apoptosis and axon growth regulation in neurons.PTEN deficiency mediates a reciprocal response to IGFI and mTOR inhibition.Cooperativity within and among Pten, p53, and Rb pathways induces high-grade astrocytoma in adult brain.Coordinate regulation of mature dopaminergic axon morphology by macroautophagy and the PTEN signaling pathway.Frontier of epilepsy research - mTOR signaling pathway.DNA-dependent protein kinase is a context dependent regulator of Lmx1a and midbrain specification.Mechanistic analysis of a DNA damage-induced, PTEN-dependent size checkpoint in human cells Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner.Endoplasmic Reticulum Stress in Heat- and Shake-Induced Injury in the Rat Small Intestine Macrophage proliferation is regulated through CSF-1 receptor tyrosines 544, 559, and 807.Decreased Phosphorylated Protein Kinase B (Akt) in Individuals with Autism Associated with High Epidermal Growth Factor Receptor (EGFR) and Low Gamma-Aminobutyric Acid (GABA).Noncanonical control of C. elegans germline apoptosis by the insulin/IGF-1 and Ras/MAPK signaling pathways Capillary Isoelectric Focusing of Akt Isoforms Identifies Highly Dynamic Phosphorylation in Neuronal Cells and Brain Tissue Neurogenesis at the brain-cerebrospinal fluid interface.Striking the balance between PTEN and PDK1: it all depends on the cell context.Mutation of the 3-phosphoinositide-dependent protein kinase-1 (PDK1) substrate-docking site in the developing brain causes microcephaly with abnormal brain morphogenesis independently of Akt, leading to impaired cognition and disruptive behaviors.The cerebrospinal fluid: regulator of neurogenesis, behavior, and beyond.Tumor suppressive pathways in the control of neurogenesis.Brain patterning perturbations following PTEN loss.Differential SKIP expression in PTEN-deficient glioblastoma regulates cellular proliferation and migration.Activated PI3Kδ syndrome type 2: Two patients, a novel mutation, and review of the literature.Detecting PTEN and PI3K Signaling in Brain Rapamycin prevents, but does not reverse, aberrant migration in Pten knockout neurons.Phosphatase and tensin homologue (PTEN) regulates synaptic plasticity independently of its effect on neuronal morphology and migration.Plausible role of naringenin against cerebrally implanted C6 glioma cells in rats.Conditional Deletion of PDK1 in the Forebrain Causes Neuron Loss and Increased Apoptosis during Cortical Development.Use of nanoparticles for glioblastoma treatment: a new approach.PTEN: a new player controlling structural and functional synaptic plasticity.PDK1 selectively phosphorylates Thr(308) on Akt and contributes to human platelet functional responses.

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P2860

Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains

http://www.wikidata.org/entity/Q33385397

description

2009 nî lūn-bûn

@nan

2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2009年の論文

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2009年論文

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2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

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name

Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains

@ast

Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains

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type

label

Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains

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Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains

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prefLabel

Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains

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Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains

@en

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Genes & Development

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Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains

@en

P2093

Guo Zhu

http://www.w3.org/2001/XMLSchema#string

Nader Chalhoub

http://www.w3.org/2001/XMLSchema#string

Suzanne J Baker

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Xiaoyan Zhu

http://www.w3.org/2001/XMLSchema#string

P2860

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

PDK1, the master regulator of AGC kinase signal transduction

Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

Essential role of PDK1 in regulating cell size and development in mice

Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma

Pten is essential for embryonic development and tumour suppression

PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

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1619-1624

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10.1101/GAD.1799609

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14

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23

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19605683

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2714713

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