Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner. - Wikidata - wikimedia - TriplyDB

Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner.

Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner.

http://www.wikidata.org/entity/Q35229380

about

Ribosomal Protein S6 Phosphorylation in the Nervous System: From Regulation to Function RASopathies: unraveling mechanisms with animal models Molecular characterizations of glioblastoma, targeted therapy, and clinical results to date The neurology of mTOR Astrocytes conspire with neurons during progression of neurological disease Potential for treatment of severe autism in tuberous sclerosis complex A phase II trial of everolimus, temozolomide, and radiotherapy in patients with newly diagnosed glioblastoma: NCCTG N057K Transformation of quiescent adult oligodendrocyte precursor cells into malignant glioma through a multistep reactivation process AKT pathway genes define 5 prognostic subgroups in glioblastoma.Using the neurofibromatosis tumor predisposition syndromes to understand normal nervous system development.Maternal diet-induced microRNAs and mTOR underlie β cell dysfunction in offspring.Loss of NF1 expression in human endothelial cells promotes autonomous proliferation and altered vascular morphogenesis.Molecular and cellular characterization of a zebrafish optic pathway tumor line implicates glia-derived progenitors in tumorigenesis.The impact of coexisting genetic mutations on murine optic glioma biology.Akt- or MEK-mediated mTOR inhibition suppresses Nf1 optic glioma growth.Deconvoluting mTOR biology Emerging insights into the molecular and cellular basis of glioblastoma.Implementation of a Molecular Tumor Board: The Impact on Treatment Decisions for 35 Patients Evaluated at Dartmouth-Hitchcock Medical Center.Partial Blindness to Submicron Topography in NF1 Haploinsufficient Cultured Fibroblasts Indicates a New Function of Neurofibromin in Regulation of Mechanosensoric.Pediatric glioma-associated KIAA1549:BRAF expression regulates neuroglial cell growth in a cell type-specific and mTOR-dependent manner.14-3-3 proteins regulate Tctp-Rheb interaction for organ growth in Drosophila.Neuronal autophagy and neurodevelopmental disorders.Conditional KIAA1549:BRAF mice reveal brain region- and cell type-specific effects.Activation of mTORC1/mTORC2 signaling in pediatric low-grade glioma and pilocytic astrocytoma reveals mTOR as a therapeutic target Physical interaction between neurofibromin and serotonin 5-HT6 receptor promotes receptor constitutive activity.Pediatric neurofibromatosis 1 and parental stress: a multicenter study Dysfunctional mTORC1 Signaling: A Convergent Mechanism between Syndromic and Nonsyndromic Forms of Autism Spectrum Disorder?Plasticity and mTOR: towards restoration of impaired synaptic plasticity in mTOR-related neurogenetic disorders The molecular and cell biology of pediatric low-grade gliomas.mTOR inhibitors as a new therapeutic option for epilepsy.Improving outcomes for neurofibromatosis 1-associated brain tumors.NF1 Is a Direct G Protein Effector Essential for Opioid Signaling to Ras in the Striatum.Metabolic reprogramming in glioblastoma: the influence of cancer metabolism on epigenetics and unanswered questions Immunohistochemical Markers for Prospective Studies in Neurofibromatosis-1 Porcine Models.Contextual signaling in cancer.Japanese encephalitis virus infection alters both neuronal and astrocytic differentiation of neural stem/progenitor cells.Proteomic analysis reveals GIT1 as a novel mTOR complex component critical for mediating astrocyte survival.Deletion of mTOR in Reactive Astrocytes Suppresses Chronic Seizures in a Mouse Model of Temporal Lobe Epilepsy.mTOR: a new therapeutic target for pediatric low-grade glioma?Nutraceuticals safety and efficacy in migraine without aura in a population of children affected by neurofibromatosis type I.

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Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner.

http://www.wikidata.org/entity/Q35229380

description

2011 nî lūn-bûn

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2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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Neurofibromatosis-1 regulates ...... a TSC/Rheb-independent manner.

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Neurofibromatosis-1 regulates ...... a TSC/Rheb-independent manner.

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Neurofibromatosis-1 regulates ...... a TSC/Rheb-independent manner.

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Neurofibromatosis-1 regulates ...... a TSC/Rheb-independent manner.

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Neurofibromatosis-1 regulates ...... a TSC/Rheb-independent manner.

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PNAS.1019012108

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Proceedings of the National Academy of Sciences of the United States of America

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Neurofibromatosis-1 regulates ...... a TSC/Rheb-independent manner

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Nikkilina R Crouse

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Ryan J Emnett

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Scott M Gianino

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Sutapa Banerjee

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P2860

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner

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15996-16001

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10.1073/PNAS.1019012108

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38

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108

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David H Gutmann

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51624052

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21896734

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3179115

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