Discovery of amyloid-beta aggregation inhibitors using an engineered assay for intracellular protein folding and solubility.
about
A microbial sensor for discovering structural probes of protein misfolding and aggregationGenetic selection designed to stabilize proteins uncovers a chaperone called SpyDevelopment and validation of a yeast high-throughput screen for inhibitors of Aβ₄₂ oligomerization.Optimizing recombinant antibodies for intracellular function using hitchhiker-mediated survival selectionCritique of the use of fluorescence-based reporters in Escherichia coli as a screening tool for the identification of peptide inhibitors of Aβ42 aggregation.Effects of secondary metabolite extract from Phomopsis occulta on β-amyloid aggregationGenerating extracellular amyloid aggregates using E. coli cells.On the design of broad based screening assays to identify potential pharmacological chaperones of protein misfolding diseasesTanshinones inhibit amyloid aggregation by amyloid-β peptide, disaggregate amyloid fibrils, and protect cultured cellsScreening strategies to identify HSP70 modulators to treat Alzheimer's disease.A bacterial export system for generating extracellular amyloid aggregates.Inhibition of amyloid oligomerization into different supramolecular architectures by small molecules: mechanistic insights and design rules.Macromolecular and small-molecule modulation of intracellular Aβ42 aggregation and associated toxicity.Using bacterial inclusion bodies to screen for amyloid aggregation inhibitors.Design, synthesis and structure-activity relationship (SAR) studies of 2,4-disubstituted pyrimidine derivatives: dual activity as cholinesterase and Aβ-aggregation inhibitors.Mining mammalian genomes for folding competent proteins using Tat-dependent genetic selection in Escherichia coli.An in vivo platform for identifying inhibitors of protein aggregation.Molecular interactions with redox sites and salt bridges modulate the anti-aggregatory effect of flavonoid, tannin and cardenolide moieties against amyloid-beta (1-42) in silicoTAT hitchhiker selection expanded to folding helpers, multimeric interactions and combinations with protein fragment complementation.
P2860
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P2860
Discovery of amyloid-beta aggregation inhibitors using an engineered assay for intracellular protein folding and solubility.
description
2009 nî lūn-bûn
@nan
2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Discovery of amyloid-beta aggr ...... rotein folding and solubility.
@ast
Discovery of amyloid-beta aggr ...... rotein folding and solubility.
@en
type
label
Discovery of amyloid-beta aggr ...... rotein folding and solubility.
@ast
Discovery of amyloid-beta aggr ...... rotein folding and solubility.
@en
prefLabel
Discovery of amyloid-beta aggr ...... rotein folding and solubility.
@ast
Discovery of amyloid-beta aggr ...... rotein folding and solubility.
@en
P2860
P356
P1433
P1476
Discovery of amyloid-beta aggr ...... rotein folding and solubility.
@en
P2093
HyungHo Ha
Li Ling Lee
P2860
P304
P356
10.1002/PRO.33
P577
2009-02-01T00:00:00Z