Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10
about
Alternative splicing of GAD67 results in the synthesis of a third form of glutamic-acid decarboxylase in human islets and other non-neural tissuesTwo human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single geneQuantitative assay using recombinant human islet glutamic acid decarboxylase (GAD65) shows that 64K autoantibody positivity at onset predicts diabetes typeImmunogenetics of type 1 diabetes mellitusAutoimmune type 1 diabetes: resolved and unresolved issuesGAD65 antibodies, chronic psychosis, and type 2 diabetes mellitusNucleotide sequence and chromosomal assignment of a cDNA encoding the large isoform of human glutamate decarboxylase.A -243A-->G polymorphism upstream of the gene encoding GAD65 associates with lower levels of body mass index and glycaemia in a population-based sample of 5857 middle-aged White subjects.HLA genes, islet autoantibodies and residual C-peptide at the clinical onset of type 1 diabetes mellitus and the risk of retinopathy 15 years later.Demonstration of GAD-65 as the main immunogenic isoform of glutamate decarboxylase in type 1 diabetes and determination of autoantibodies using a radioligand produced by eukaryotic expression.Prevalence of autoantibodies to the 65- and 67-kD isoforms of glutamate decarboxylase in insulin-dependent diabetes mellitusGenetic association analysis of behavioral inhibition using candidate loci from mouse models.Secretagogin is a Ca2+-binding protein identifying prospective extended amygdala neurons in the developing mammalian telencephalon.Detection of pancreatic islet 64,000 M(r) autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylaseCellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetesVaccination against type 1 diabetes.High-affinity binding of short peptides to major histocompatibility complex class II molecules by anchor combinationsIslet cell cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetesType 1 diabetes as a model for prediction and diagnosis.Prediction and prevention of type 1 diabetes: update on success of prediction and struggles at preventionGAD65 autoantibodies and its role as biomarker of Type 1 diabetes and Latent Autoimmune Diabetes in Adults (LADA).Autoreactive epitopes defined by diabetes-associated human monoclonal antibodies are localized in the middle and C-terminal domains of the smaller form of glutamate decarboxylaseHumoral autoimmunity in type 1 diabetes: prediction, significance, and detection of distinct disease subtypes.Glutamic acid decarboxylase 67-reactive T cells: a marker of insulin-dependent diabetes.Genes in the GABA Pathway Increase in the Lateral Thalamus of Sprague-Dawley Rats During the Proestrus/Estrus Phase.Primary structure and cellular localization of chicken brain myosin-V (p190), an unconventional myosin with calmodulin light chainsMembrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic beta-cells by palmitoylation in the NH2-terminal domainHSV vector-mediated GAD67 suppresses neuropathic pain induced by perineural HIV gp120 in rats through inhibition of ROS and Wnt5aAn islet-cell protein tyrosine phosphatase is a likely precursor to the 37-kDa autoantigen in type 1 diabetes: human and macaque sequences, tissue distribution, unique and shared epitopes, and predictive autoantibodies.Association of the -243A>G, +61450C>A Polymorphisms of the Glutamate Decarboxylase 2 (GAD2) Gene with Obesity and Insulin Level in North Indian PopulationGlutamic acid decarboxylase autoantibodies in preclinical insulin-dependent diabetesCloning and characterization of myr 6, an unconventional myosin of the dilute/myosin-V family.Decreased GAD65 mRNA levels in select subpopulations of neurons in the cerebellar dentate nuclei in autism: an in situ hybridization study.Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401.Circulating Zonulin Correlates with Density of Enteroviruses and Tolerogenic Dendritic Cells in the Small Bowel Mucosa of Celiac Disease Patients.Involvement of the proteasome in IL-1beta induced suppression of islets of Langerhans in the rat.Autoantigens in type 1 diabetes mellitus.GAD, diabetes, and Stiff-Man syndrome: some progress and more questions.Quantitative analysis of islet glutamic acid decarboxylase p64 autoantibodies in insulin-dependent diabetes mellitus.A signal located within amino acids 1-27 of GAD65 is required for its targeting to the Golgi complex region.
P2860
Q22253174-E434D5C2-22F5-4900-AECE-2FDDE2D1E0D8Q24307858-0745756F-B8F9-4FA0-863D-DE99CB13FA1BQ24617932-8D99FD0C-321F-4A24-81CB-CB2192AD1EFFQ28087365-FE522B34-6226-4F21-B215-6FDECBE02C1FQ28363451-68F21104-D46D-44BB-845D-DC6E6341C6E6Q30430711-F50E5B3A-87F6-418F-B684-0835D8303E21Q30808583-76D041E9-1EFD-4DAC-9F87-7962235B6E87Q33282777-0EC44E4D-CF7C-4148-A698-0C7CC790737AQ33848973-B9427111-F9B6-44CF-A0AB-6FC8FCE8D444Q33899197-40FEFB7D-CA16-421F-A9A3-6BC98B9AB0ECQ33902290-2FD82BB5-5C5F-4173-A9AB-5E53D9DDB6DDQ33946742-D9DCC0F5-406C-4ACA-9E20-66D3FF5E8756Q34051132-E23AFB2A-D747-4A8C-887E-86F60B7F1218Q34111857-698D01B0-4224-4519-BA36-9E8AB8BC45CAQ34159440-C3CB68B8-FAE3-47B1-A62E-4A7A7AC5F4CFQ35004343-537BA669-B7DF-4129-8FCD-20351DB2DE4AQ35235094-E583799A-C210-4AF3-BB03-76DDA8EB5A23Q35824175-6C59B47F-AB04-4230-80A9-00FA57C92F8FQ35934762-995723B1-E5A7-4F0A-A487-B118CB76A367Q36117948-BB371F3B-9A52-417C-AB7E-422DD64AA970Q36137876-650B2F84-AAF1-4995-B73C-13E895FA0A23Q36202374-D6D7E559-B9C6-4D41-AF34-8A34FF7E90D8Q36330292-E4EBD904-7BFA-4E0E-BAD7-62680C843EF1Q36361272-48D74824-D5BE-42B7-958A-6DE023AFED27Q36505520-F99FEF0A-3B1D-4A53-BA8F-DBC59C35D448Q36532404-946EEC3C-033F-465C-BD2C-D228766F1E14Q36533216-81BBD5AF-544E-4B2B-AA8A-080D44AF7C47Q36777541-191BB195-AD6C-4E27-BAEA-41173C6FABEDQ36853549-F98E9838-BEB9-4F2B-9D28-E48D477C89E5Q36954438-6D7E2F82-1F48-40C6-8AE1-4D3AD16E4D68Q37255494-579AF307-F820-4161-AE53-50F7F39E59CCQ37297817-B5BA358E-E325-4665-ABE1-45618BEFBFB2Q37299778-0D9A6702-A696-45EA-8E7C-03F766E37FD9Q39774757-C77DF285-E502-4E4C-8C93-05F1326FC9F0Q40416734-10ABD777-61D2-454F-991D-F1BD55A6FE95Q40569816-3D0F4E41-C71D-4196-A2CE-D74BBBD382BDQ40575830-0EFE547A-6472-4121-96E3-EF311662E03DQ40575836-0AD659C9-AD75-421E-92E4-51837A9FA37DQ41131246-79BB1A32-4937-40C8-BF27-995362DDBDD8Q41982714-AFF4AEC0-06A2-49D2-8B6E-84E279B861F4
P2860
Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10
description
1991 nî lūn-bûn
@nan
1991 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
name
Cloning and primary structure ...... carboxylase from chromosome 10
@ast
Cloning and primary structure ...... carboxylase from chromosome 10
@en
type
label
Cloning and primary structure ...... carboxylase from chromosome 10
@ast
Cloning and primary structure ...... carboxylase from chromosome 10
@en
prefLabel
Cloning and primary structure ...... carboxylase from chromosome 10
@ast
Cloning and primary structure ...... carboxylase from chromosome 10
@en
P2093
P2860
P356
P1476
Cloning and primary structure ...... carboxylase from chromosome 10
@en
P2093
A E Karlsen
C E Grubin
C M Disteche
H Bärmeier
S Mathewes
W A Hagopian
P2860
P304
P356
10.1073/PNAS.88.19.8337
P407
P577
1991-10-01T00:00:00Z