A conserved mechanism for control of human and mouse embryonic stem cell pluripotency and differentiation by shp2 tyrosine phosphatase.
about
Src homology-2 domain-containing protein tyrosine phosphatase (SHP) 2 and p38 regulate the expression of chemokine CXCL8 in human astrocytesPtpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesisSalicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2)Gab2 regulates cytoskeletal organization and migration of mammary epithelial cells by modulating RhoA activationA homozygous mutant embryonic stem cell bank applicable for phenotype-driven genetic screening.High-throughput fluorescence assay for small-molecule inhibitors of autophagins/Atg4.A genome-wide siRNA screen identifies novel phospho-enzymes affecting Wnt/β-catenin signaling in mouse embryonic stem cells.Tyrosine phosphatase Shp2 mediates the estrogen biological action in breast cancer via interaction with the estrogen extranuclear receptor.Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening.Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112.Therapeutic potential of targeting the oncogenic SHP2 phosphatase.LEOPARD syndrome-associated SHP2 mutation confers leanness and protection from diet-induced obesityKit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool.The role of the protein tyrosine phosphatase SHP2 in cardiac development and disease.Discovery of a Novel Inhibitor of the Protein Tyrosine Phosphatase Shp2.Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase.Shp2 Associates with and Enhances Nephrin Tyrosine Phosphorylation and Is Necessary for Foot Process Spreading in Mouse Models of Podocyte Injury.Protein post-translational modifications and regulation of pluripotency in human stem cells.The Role of the Leukemia Inhibitory Factor (LIF) - Pathway in Derivation and Maintenance of Murine Pluripotent Stem Cells.Shp2 Inhibits Proliferation of Esophageal Squamous Cell Cancer via Dephosphorylation of Stat3Key players in the gene networks guiding ESCs toward mesoderm.Dual faces of SH2-containing protein-tyrosine phosphatase Shp2/PTPN11 in tumorigenesis.Concise review: Mechanotransduction via p190RhoGAP regulates a switch between cardiomyogenic and endothelial lineages in adult cardiac progenitors.LEOPARD-type SHP2 mutant Gln510Glu attenuates cardiomyocyte differentiation and promotes cardiac hypertrophy via dysregulation of Akt/GSK-3β/β-catenin signaling.SHP2 is a downstream target of ZAP70 to regulate JAK1/STAT3 and ERK signaling pathways in mouse embryonic stem cells.
P2860
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P2860
A conserved mechanism for control of human and mouse embryonic stem cell pluripotency and differentiation by shp2 tyrosine phosphatase.
description
2009 nî lūn-bûn
@nan
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
A conserved mechanism for cont ...... by shp2 tyrosine phosphatase.
@ast
A conserved mechanism for cont ...... by shp2 tyrosine phosphatase.
@en
type
label
A conserved mechanism for cont ...... by shp2 tyrosine phosphatase.
@ast
A conserved mechanism for cont ...... by shp2 tyrosine phosphatase.
@en
prefLabel
A conserved mechanism for cont ...... by shp2 tyrosine phosphatase.
@ast
A conserved mechanism for cont ...... by shp2 tyrosine phosphatase.
@en
P2093
P2860
P1433
P1476
A conserved mechanism for cont ...... by shp2 tyrosine phosphatase.
@en
P2093
Dongmei Wu
Gen-Sheng Feng
Jianxiu Yu
Sheng Ding
Tomas Mustelin
Yuhong Pang
Ziwei Huang
P2860
P356
10.1371/JOURNAL.PONE.0004914
P407
P50
P577
2009-03-17T00:00:00Z