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DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down SyndromeAn overview of the synthetic routes to the best selling drugs containing 6-membered heterocyclesRecent trends and observations in the design of high-quality screening collections.Novel chiral skeletons for drug discovery: antibacterial tetramic acids.Scaffold diversity of exemplified medicinal chemistry space.Chiral bicyclic tetramates as non-planar templates for chemical library synthesis.Balancing novelty with confined chemical space in modern drug discovery.Synthesis of 3-acyltetramates by side chain manipulation and their antibacterial activity.A chemo-centric view of human health and diseaseA facile, metal- and solvent-free, autoxidative coupling of quinolines with indoles and pyrroles.Concise synthesis of rare pyrido[1,2-a]pyrimidin-2-ones and related nitrogen-rich bicyclic scaffolds with a ring-junction nitrogen.Classification of scaffold-hopping approachesDrug search for leishmaniasis: a virtual screening approach by grid computing.Applications of Systematic Molecular Scaffold Enumeration to Enrich Structure-Activity Relationship Information.Direct Assembly of Prenylated Heteroarenes through a Cascade Minisci Reaction/Dehydration Sequence.The influence of the 'organizational factor' on compound quality in drug discovery.A unified access to diverse heteroaromatic scaffolds using the radical chemistry of xanthates.What does the aromatic ring number mean for drug design?Modern advances in heterocyclic chemistry in drug discovery.1-Acetyl-3,5-diaryl-4,5-dihydro(1H)pyrazoles: exhibiting anticancer activity through intracellular ROS scavenging and the mitochondria-dependent death pathway.A selective intramolecular 5-exo-dig or 6-endo-dig cyclization en route to 2-furanone or 2-pyrone containing tricyclic scaffolds.Microwave-promoted synthesis of 3-amino-substituted 1,2-benzisoxazoles.9,10-Dioxa-1,2-diaza-anthracene derivatives from tetrafluoropyridazineDesign and synthesis of novel iminothiazinylbutadienols and divinylpyrimidinethiones as ARE inducers.Staring off into chemical space.Synthesis of functionalised 4H-quinolizin-4-ones via tandem Horner-Wadsworth-Emmons olefination/cyclisation.Quinocidin, a Cytotoxic Antibiotic with an Unusual 3,4-Dihydroquinolizinium Ring and Michael Acceptor Reactivity toward Thiols.Negishi cross-couplings in the synthesis of amino acids.Asymmetric Synthesis of 1,3-Oxazolidine Derivatives with Multi-Component Reaction and Research of Kinetic Resolution.The utilization of spirocyclic scaffolds in novel drug discovery.Cation-π interactions in protein-ligand binding: theory and data-mining reveal different roles for lysine and arginine.A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc03115j.Benzo[c]isothiazole 2-Oxides: Three-Dimensional Heterocycles with Cross-Coupling and Functionalization PotentialConcise Synthesis of Substituted Quinolizin-4-ones by Ring-Closing MetathesisChemical motifs that redox cycle and their associated toxicityDiscovery of High-Affinity Cannabinoid Receptors Ligands through a 3D-QSAR Ushered by Scaffold-Hopping Analysis
P2860
Q26745413-A95EBED5-3A3B-4114-A948-AB68CD32CF77Q28301501-E9E3D649-BCC6-4EC7-A388-293E662732CAQ33893113-75C18183-3930-4E1B-A8CF-072F18716913Q33893201-A1441541-F1E1-4CE9-8769-48C7A1C80EEAQ34005814-7F80489A-1DD5-4658-81AE-2B77B679A46DQ34563803-E54610F0-5BDD-4FC2-82AD-B48127857B6EQ35071339-20C8DBEF-33A9-493A-88AA-D16B171B81C1Q35090265-EBDD3C37-8950-43A3-9CD7-E80F2D9E856FQ35114229-6C87D596-6242-4649-AB3A-4412D41D721DQ35603424-1775D598-31CB-43B7-89B0-382BA88BC9C6Q35859727-FCB23A5F-9BAB-46D3-82F1-5D448820BBA9Q35893996-E423418F-044E-465D-8488-E60AAD1AF30FQ36082949-F2007E8D-6F6C-4C2C-B455-BCB21CD46323Q36227748-41716C68-95BB-4036-85DB-4E6685416CD2Q37515407-92515AB6-59DB-46D5-8784-72D3602FBE26Q37940789-29071C34-E513-4599-98B0-12F817BF8C00Q37995516-C8C0E996-E6D5-4932-8AC6-E0C5516697DBQ38222473-80D89BA0-B3C2-4747-82A8-C91DEB08ACB7Q38860432-7A6847BC-D9B5-4AE8-92C1-D9E56CA4630DQ38964410-77DF7AE1-4A3D-4802-B0B6-1C02DB1C3F05Q39408006-B39F19BE-C85B-4557-B7F3-F54AC189DBFCQ39769157-77741C06-053F-45E9-A5EE-98F297A86E30Q41135828-BFF39913-218D-48EA-946E-0E12C973C273Q41981782-F71000FA-1655-486D-B1AA-E1017ED76DEBQ42562538-3595D332-65BE-437F-BF40-0A6873BAC6E1Q43927581-D087F597-4B29-43C4-B57C-1C94A6FE05ECQ47438870-0E697671-0EF5-445B-9EDE-FBAC3E5D1F88Q48189636-5454C940-30D3-4641-9AC3-A3BD89482E4AQ51712106-5931F5AD-9F89-4DB0-BD31-80EE4B1173ABQ53755762-A46B2E9B-A985-4B1A-816D-DD5D91465E28Q54966121-95AD7D7D-CCC9-48DA-B2CC-10E0AA56EB84Q55098311-C50B2C5B-33D0-43C0-BC08-1558BAAD4BFCQ57404720-8F62A256-A254-48FD-B886-F65BBC2BCBC9Q57540610-D376E9D8-7D53-4C85-B743-22305A0FDADCQ58293268-9499BCF8-AABD-4301-B27A-F195FFA92672Q58696615-39EE1F64-5C5D-4745-B207-878846224BEA
P2860
description
2009 nî lūn-bûn
@nan
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Heteroaromatic rings of the future.
@ast
Heteroaromatic rings of the future.
@en
type
label
Heteroaromatic rings of the future.
@ast
Heteroaromatic rings of the future.
@en
prefLabel
Heteroaromatic rings of the future.
@ast
Heteroaromatic rings of the future.
@en
P356
P1476
Heteroaromatic rings of the future
@en
P2093
Benjamin G Perry
William R Pitt
P304
P356
10.1021/JM801513Z
P407
P577
2009-05-01T00:00:00Z