PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment. - Wikidata - wikimedia - TriplyDB

PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment.

PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment.

http://www.wikidata.org/entity/Q33427833

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Compensatory angiogenesis and tumor refractoriness Mechanisms of evasive resistance to anti-VEGF therapy in glioblastoma Adaptation to antiangiogenic therapy in neurological tumors Molecular mechanisms and clinical applications of angiogenesis Anti-vascular endothelial growth factor therapies as a novel therapeutic approach to treating neurofibromatosis-related tumors.Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia.Vascular normalization as a therapeutic strategy for malignant and nonmalignant disease.Normalization of the vasculature for treatment of cancer and other diseases.Glioblastoma behaviors in three-dimensional collagen-hyaluronan composite hydrogels.Phase II trial of pazopanib (GW786034), an oral multi-targeted angiogenesis inhibitor, for adults with recurrent glioblastoma (North American Brain Tumor Consortium Study 06-02).Intravital imaging of stromal cell dynamics in tumors A dual-targeting PDGFRbeta/VEGF-A molecule assembled from stable antibody fragments demonstrates anti-angiogenic activity in vitro and in vivo.Platelet-derived growth factor (PDGF)-C inhibits neuroretinal apoptosis in a murine model of focal retinal degeneration.Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions.Vascular effects, efficacy and safety of nintedanib in patients with advanced, refractory colorectal cancer: a prospective phase I subanalysis VEGF-independent angiogenic pathways induced by PDGF-C.In vivo optical imaging of tumor and microvascular response to ionizing radiation Effect of Avastin on the number and structure of tumor blood vessels of nude mice with A549 lung adenocarcinoma.Multi-study integration of brain cancer transcriptomes reveals organ-level molecular signatures Mechanisms of resistance to anti-angiogenic therapy and development of third-generation anti-angiogenic drug candidates.PDGF-D improves drug delivery and efficacy via vascular normalization, but promotes lymphatic metastasis by activating CXCR4 in breast cancer.Engineered blood vessel networks connect to host vasculature via wrapping-and-tapping anastomosis Platelet-derived growth factor C deficiency in C57BL/6 mice leads to abnormal cerebral vascularization, loss of neuroependymal integrity, and ventricular abnormalities.Platelet-derived growth factor receptor alpha in glioma: a bad seed Phase I trial, pharmacokinetics, and pharmacodynamics of vandetanib and dasatinib in children with newly diagnosed diffuse intrinsic pontine glioma.PDGFRα depletion attenuates glioblastoma stem cells features by modulation of STAT3, RB1 and multiple oncogenic signals PDGF-CC underlies resistance to VEGF-A inhibition and combinatorial targeting of both suppresses pathological angiogenesis more efficiently.Angiogenesis inhibitors in cancer therapy: mechanistic perspective on classification and treatment rationales.Antiangiogenesis therapy: an update after the first decade.Pathogenetic significance and possibility as a therapeutic target of platelet derived growth factor.Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy Platelet-Derived Growth Factor (PDGF)/PDGF Receptors (PDGFR) Axis as Target for Antitumor and Antiangiogenic Therapy.Annexin A2 is a molecular target for TM601, a peptide with tumor-targeting and anti-angiogenic effects.Upregulated stromal EGFR and vascular remodeling in mouse xenograft models of angiogenesis inhibitor-resistant human lung adenocarcinoma.Tumor cells expressing tissue factor influence the migration of smooth muscle cells in a catalytic activity-dependent way.LIM-homeobox gene 2 promotes tumor growth and metastasis by inducing autocrine and paracrine PDGF-B signaling A Review of Anti-Angiogenic Targets for Monoclonal Antibody Cancer Therapy Tumor dynamics in response to antiangiogenic therapy with oral metronomic topotecan and pazopanib in neuroblastoma xenografts.Impact of exploratory biomarkers on the treatment effect of bevacizumab in metastatic breast cancer Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice.

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P2860

PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment.

http://www.wikidata.org/entity/Q33427833

description

2009 nî lūn-bûn

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2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2009 թվականի ապրիլին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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PDGF-C induces maturation of b ...... sponse to anti-VEGF treatment.

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JOURNAL.PONE.0005123

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PDGF-C induces maturation of b ...... sponse to anti-VEGF treatment.

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Daniel Fuja

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Emmanuelle di Tomaso

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James A Tyrrell

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James Logie

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Lance L Munn

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Nyall London

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Rakesh K Jain

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Walid Kamoun

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P2860

Mechanism of action and in vivo role of platelet-derived growth factor

PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor

Modes of resistance to anti-angiogenic therapy

PDGF-D, a new protease-activated growth factor

AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients.

Targeting PDGF signaling in carcinoma-associated fibroblasts controls cervical cancer in mouse model

Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice.

Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke.

Endothelial cell hyperplasia in human glioblastoma: coexpression of mRNA for platelet-derived growth factor (PDGF) B chain and PDGF receptor suggests autocrine growth stimulation.

PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor.

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19352490

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