Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium.
about
Evc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleusTargeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI InhibitorsHedgehog signaling pathway in ovarian cancerDecoding the phosphorylation code in Hedgehog signal transductionCholesterol metabolism is required for intracellular hedgehog signal transduction in vivoThe ciliary membrane.Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothenedA novel synthetic smoothened antagonist transiently inhibits pancreatic adenocarcinoma xenografts in a mouse modelProtein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tubeImpact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activityThe future of ciliary and flagellar membrane research.Coordinated translocation of mammalian Gli proteins and suppressor of fused to the primary ciliumMechanism and evolution of cytosolic Hedgehog signal transductionTargeting Hedgehog--a cancer stem cell pathwaySimultaneous measurement of smoothened entry into and exit from the primary cilium.The side population in human lung cancer cell line NCI-H460 is enriched in stem-like cancer cells.Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation.NL-103, a novel dual-targeted inhibitor of histone deacetylases and hedgehog pathway, effectively overcomes vismodegib resistance conferred by Smo mutations.Smoothened Regulation: A Tale of Two Signals.Lateral transport of Smoothened from the plasma membrane to the membrane of the ciliumClinical implications of hedgehog signaling pathway inhibitorsThe hedgehog/Gli signaling paradigm in prostate cancerHedgehog pathway as a drug target: Smoothened inhibitors in development.Dopamine receptor 1 localizes to neuronal cilia in a dynamic process that requires the Bardet-Biedl syndrome proteins.Regulation of Hedgehog signaling by ubiquitination.Smoothened regulation in response to Hedgehog stimulation.Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiationSmoothened determines β-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary ciliumEndogenous B-ring oxysterols inhibit the Hedgehog component Smoothened in a manner distinct from cyclopamine or side-chain oxysterols.Glucocorticoid compounds modify smoothened localization and hedgehog pathway activityGli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus.Activation of the hedgehog-signaling pathway in human cancer and the clinical implications.The primary cilium as a Hedgehog signal transduction machine.Hedgehog signaling in skin cancersThe Hedgehog's tale: developing strategies for targeting cancer.Mechanisms of Hedgehog signalling in cancer.Small molecule inhibitors of the hedgehog signaling pathway for the treatment of cancer.The sonic hedgehog-GLI1 signaling pathway in brain tumor development.Hedgehog signaling from the primary cilium to the nucleus: an emerging picture of ciliary localization, trafficking and transductionRegulation of the oncoprotein Smoothened by small molecules.
P2860
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P2860
Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium.
description
2009 nî lūn-bûn
@nan
2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Smoothened adopts multiple act ...... ficking to the primary cilium.
@ast
Smoothened adopts multiple act ...... ficking to the primary cilium.
@en
type
label
Smoothened adopts multiple act ...... ficking to the primary cilium.
@ast
Smoothened adopts multiple act ...... ficking to the primary cilium.
@en
prefLabel
Smoothened adopts multiple act ...... ficking to the primary cilium.
@ast
Smoothened adopts multiple act ...... ficking to the primary cilium.
@en
P2860
P1433
P1476
Smoothened adopts multiple act ...... ficking to the primary cilium.
@en
P2093
Christopher W Wilson
Pao-Tien Chuang
P2860
P356
10.1371/JOURNAL.PONE.0005182
P407
P577
2009-04-13T00:00:00Z