Inferring stabilizing mutations from protein phylogenies: application to influenza hemagglutinin.
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Consensus protein designCauses of evolutionary rate variation among protein sitesModulation of protein stability and aggregation properties by surface charge engineering.High-throughput profiling of influenza A virus hemagglutinin gene at single-nucleotide resolutionA model for protein sequence evolution based on selective pressure for protein stability: application to hemoglobinsBiophysical Models of Protein Evolution: Understanding the Patterns of Evolutionary Sequence Divergence.A computational-experimental approach identifies mutations that enhance surface expression of an oseltamivir-resistant influenza neuraminidase.Consensus protein design without phylogenetic biasPermissive secondary mutations enable the evolution of influenza oseltamivir resistance.Biophysics of protein evolution and evolutionary protein biophysicsBringing molecules back into molecular evolution.Coevolutionary Landscape Inference and the Context-Dependence of Mutations in Beta-Lactamase TEM-1.The relationship between relative solvent accessibility and evolutionary rate in protein evolution.Biophysical fitness landscapes for transcription factor binding sitesSelecting vaccine strains for H3N2 human influenza A virus.Universal distribution of mutational effects on protein stability, uncoupling of protein robustness from sequence evolution and distinct evolutionary modes of prokaryotic and eukaryotic proteins.The effects of a deleterious mutation load on patterns of influenza A/H3N2's antigenic evolution in humansClonal interference in the evolution of influenzaA fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function.A universal scaling law determines time reversibility and steady state of substitutions under selection.The population genetics of drug resistance evolution in natural populations of viral, bacterial and eukaryotic pathogensMutational effects on stability are largely conserved during protein evolution.Dynamics and constraints of enzyme evolution.Stabilization of a nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator yields insight into disease-causing mutations.Protein stability: a single recorded mutation aids in predicting the effects of other mutations in the same amino acid site.Relationship between protein thermodynamic constraints and variation of evolutionary rates among sites.The Bioinformatics Report of Mutation Outcome on NADPH Flavin Oxidoreductase Protein Sequence in Clinical Isolates of H. pylori.Evolutionary interplay between structure, energy and epistasis in the coat protein of the ϕX174 phage family.A predictive fitness model for influenza.Linking genotype and phenotype of Saccharomyces cerevisiae strains reveals metabolic engineering targets and leads to triterpene hyper-producers.Stability of the Influenza Virus Hemagglutinin Protein Correlates with Evolutionary Dynamics.Effects of point mutations on the thermostability of B. subtilis lipase: investigating nonadditivity.On the Potential Origins of the High Stability of Reconstructed Ancestral Proteins.Enhanced ER proteostasis and temperature differentially impact the mutational tolerance of influenza hemagglutinin
P2860
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P2860
Inferring stabilizing mutations from protein phylogenies: application to influenza hemagglutinin.
description
2009 nî lūn-bûn
@nan
2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Inferring stabilizing mutation ...... on to influenza hemagglutinin.
@ast
Inferring stabilizing mutation ...... on to influenza hemagglutinin.
@en
type
label
Inferring stabilizing mutation ...... on to influenza hemagglutinin.
@ast
Inferring stabilizing mutation ...... on to influenza hemagglutinin.
@en
prefLabel
Inferring stabilizing mutation ...... on to influenza hemagglutinin.
@ast
Inferring stabilizing mutation ...... on to influenza hemagglutinin.
@en
P2860
P1476
Inferring stabilizing mutation ...... on to influenza hemagglutinin.
@en
P2093
Matthew J Glassman
P2860
P304
P356
10.1371/JOURNAL.PCBI.1000349
P577
2009-04-17T00:00:00Z