Random insertion mutagenesis of sindbis virus nonstructural protein 2 and selection of variants incapable of downregulating cellular transcription
about
Evasion of the innate immune response: the Old World alphavirus nsP2 protein induces rapid degradation of Rpb1, a catalytic subunit of RNA polymerase IIMutations conferring a noncytotoxic phenotype on chikungunya virus replicons compromise enzymatic properties of nonstructural protein 2Novel functions of the alphavirus nonstructural protein nsP3 C-terminal region.Sindbis virus usurps the cellular HuR protein to stabilize its transcripts and promote productive infections in mammalian and mosquito cells.Inhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays.High-resolution functional profiling of the norovirus genomeDesign of chimeric alphaviruses with a programmed, attenuated, cell type-restricted phenotype.ATM kinase is activated by sindbis viral vector infection.Magnetic fractionation and proteomic dissection of cellular organelles occupied by the late replication complexes of Semliki Forest virusInhibition of host protein synthesis by Sindbis virus: correlation with viral RNA replication and release of nuclear proteins to the cytoplasm.Mapping of Chikungunya virus interactions with host proteins identified nsP2 as a highly connected viral component.Functional Sindbis virus replicative complexes are formed at the plasma membrane.Identification of tolerated insertion sites in poliovirus non-structural proteinsSemliki forest virus-induced endoplasmic reticulum stress accelerates apoptotic death of mammalian cells.Can understanding the virulence mechanisms of RNA viruses lead us to a vaccine against eastern equine encephalitis virus and other alphaviruses?Early events in alphavirus replication determine the outcome of infection.Nonstructural Proteins of Alphavirus-Potential Targets for Drug Development.The Regulation of Translation in Alphavirus-Infected Cells.Comparative Characterization of the Sindbis Virus Proteome from Mammalian and Invertebrate Hosts Identifies nsP2 as a Component of the Virus Nucleocapsid and Sorting Nexin 5 as a Significant Host Factor for Alphavirus Replication.
P2860
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P2860
Random insertion mutagenesis of sindbis virus nonstructural protein 2 and selection of variants incapable of downregulating cellular transcription
description
2009 nî lūn-bûn
@nan
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Random insertion mutagenesis o ...... ulating cellular transcription
@ast
Random insertion mutagenesis o ...... ulating cellular transcription
@en
type
label
Random insertion mutagenesis o ...... ulating cellular transcription
@ast
Random insertion mutagenesis o ...... ulating cellular transcription
@en
prefLabel
Random insertion mutagenesis o ...... ulating cellular transcription
@ast
Random insertion mutagenesis o ...... ulating cellular transcription
@en
P2860
P356
P1433
P1476
Random insertion mutagenesis o ...... ulating cellular transcription
@en
P2093
Natalia Garmashova
Svetlana Atasheva
P2860
P304
P356
10.1128/JVI.00850-09
P577
2009-07-01T00:00:00Z