about
Novel chikungunya vaccine candidate with an IRES-based attenuation and host range alteration mechanismCis-acting RNA elements at the 5' end of Sindbis virus genome RNA regulate minus- and plus-strand RNA synthesis.Utilization of an Eilat Virus-Based Chimera for Serological Detection of Chikungunya InfectionDual mechanisms of pestiviral superinfection exclusion at entry and RNA replication.Efficient Translation Initiation Is Required for Replication of Bovine Viral Diarrhea Virus Subgenomic RepliconsInhibition of Transcription and Translation in Sindbis Virus-Infected CellsFormation of nsP3-Specific Protein Complexes during Sindbis Virus ReplicationDevelopment of Sindbis Viruses Encoding nsP2/GFP Chimeric Proteins and Their Application for Studying nsP2 FunctioningAlpha-beta T cells provide protection against lethal encephalitis in the murine model of VEEV infectionChimeric Sindbis/eastern equine encephalitis vaccine candidates are highly attenuated and immunogenic in miceProduction of Pseudoinfectious Yellow Fever Virus with a Two-Component GenomeStructural and Nonstructural Protein Genome Regions of Eastern Equine Encephalitis Virus Are Determinants of Interferon Sensitivity and Murine VirulenceNoncytopathic Sindbis virus RNA vectors for heterologous gene expressionProduction and characterization of vaccines based on flaviviruses defective in replicationIdentification of Mutated Cyclization Sequences That Permit Efficient Replication of West Nile Virus Genomes: Use in Safer Propagation of a Novel Vaccine CandidateIRES-dependent replication of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cellsChimeric alphavirus vaccine candidates for chikungunyaEfficient, trans-complementing packaging systems for chimeric, pseudoinfectious dengue 2/yellow fever virusesA chikungunya fever vaccine utilizing an insect-specific virus platformRandom insertion mutagenesis of sindbis virus nonstructural protein 2 and selection of variants incapable of downregulating cellular transcriptionInfection of human dendritic cells by a sindbis virus replicon vector is determined by a single amino acid substitution in the E2 glycoprotein.Noncytopathic replication of Venezuelan equine encephalitis virus and eastern equine encephalitis virus replicons in Mammalian cells.Infection, dissemination, and transmission of a West Nile virus green fluorescent protein infectious clone by Culex pipiens quinquefasciatus mosquitoes.Enhancement of protein expression by alphavirus replicons by designing self-replicating subgenomic RNAs.Roles of nonstructural protein nsP2 and Alpha/Beta interferons in determining the outcome of Sindbis virus infection.Replication and clearance of Venezuelan equine encephalitis virus from the brains of animals vaccinated with chimeric SIN/VEE viruses.IRES-driven expression of the capsid protein of the Venezuelan equine encephalitis virus TC-83 vaccine strain increases its attenuation and safetyVenezuelan equine encephalitis virus variants lacking transcription inhibitory functions demonstrate highly attenuated phenotype.Design of chimeric alphaviruses with a programmed, attenuated, cell type-restricted phenotype.Stable alphavirus packaging cell lines for Sindbis virus and Semliki Forest virus-derived vectors.Chimeric Chikungunya viruses are nonpathogenic in highly sensitive mouse models but efficiently induce a protective immune response.IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I InterferonChimeric alphavirus vaccine candidates protect mice from intranasal challenge with western equine encephalitis virus.Recombinant sindbis/Venezuelan equine encephalitis virus is highly attenuated and immunogenic.New World and Old World Alphaviruses Have Evolved to Exploit Different Components of Stress Granules, FXR and G3BP Proteins, for Assembly of Viral Replication Complexes.Analysis of Venezuelan equine encephalitis virus capsid protein function in the inhibition of cellular transcriptionA chimeric Sindbis-based vaccine protects cynomolgus macaques against a lethal aerosol challenge of eastern equine encephalitis virus.Alphavirus-based expression vectors: strategies and applications.Third-generation flavivirus vaccines based on single-cycle, encapsidation-defective viruses.Hypervariable Domain of Eastern Equine Encephalitis Virus nsP3 Redundantly Utilizes Multiple Cellular Proteins for Replication Complex Assembly.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Ilya Frolov
@ast
Ilya Frolov
@en
Ilya Frolov
@es
Ilya Frolov
@nl
Ilya Frolov
@sl
type
label
Ilya Frolov
@ast
Ilya Frolov
@en
Ilya Frolov
@es
Ilya Frolov
@nl
Ilya Frolov
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prefLabel
Ilya Frolov
@ast
Ilya Frolov
@en
Ilya Frolov
@es
Ilya Frolov
@nl
Ilya Frolov
@sl
P106
P1153
7004932729
P21
P31
P496
0000-0002-8548-2517