The inactivation of the sortilin gene leads to a partial disruption of prosaposin trafficking to the lysosomes.
about
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locusMechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease riskThe protective role of prosaposin and its receptors in the nervous systemSortilin, encoded by the cardiovascular risk gene SORT1, and its suggested functions in cardiovascular diseaseIncreased Brain Neurotensin and NTSR2 Lead to Weak Nociception in NTSR3/Sortilin Knockout MiceProNGF induces TNFalpha-dependent death of retinal ganglion cells through a p75NTR non-cell-autonomous signaling pathwayLysosomal function in macromolecular homeostasis and bioenergetics in Parkinson's disease.Sortilin: an unusual suspect in cholesterol metabolism: from GWAS identification to in vivo biochemical analyses, sortilin has been identified as a novel mediator of human lipoprotein metabolism.Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.Sortilin associates with transforming growth factor-beta family proteins to enhance lysosome-mediated degradation.Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other.Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism.Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration.Regional expression of prosaposin in the wild-type and saposin D-deficient mouse brain detected by an anti-mouse prosaposin-specific antibody.Genetics of coronary heart disease: towards causal mechanisms, novel drug targets and more personalized prevention.Progranulin, lysosomal regulation and neurodegenerative disease.Subcellular Trafficking of Mammalian Lysosomal Proteins: An Extended View.Development of a Cell-Based Assay to Assess Binding of the proNGF Prodomain to Sortilin.Molecular and computational analyses of genes involved in mannose 6-phosphate independent traffickingAltered Trek-1 Function in Sortilin Deficient Mice Results in Decreased Depressive-Like Behavior
P2860
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P2860
The inactivation of the sortilin gene leads to a partial disruption of prosaposin trafficking to the lysosomes.
description
2009 nî lūn-bûn
@nan
2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The inactivation of the sortil ...... trafficking to the lysosomes.
@ast
The inactivation of the sortil ...... trafficking to the lysosomes.
@en
type
label
The inactivation of the sortil ...... trafficking to the lysosomes.
@ast
The inactivation of the sortil ...... trafficking to the lysosomes.
@en
prefLabel
The inactivation of the sortil ...... trafficking to the lysosomes.
@ast
The inactivation of the sortil ...... trafficking to the lysosomes.
@en
P2093
P1476
The inactivation of the sortil ...... trafficking to the lysosomes.
@en
P2093
Carlos R Morales
Jesse Racicott
Jibin Zeng
P304
P356
10.1016/J.YEXCR.2009.08.016
P407
P577
2009-09-02T00:00:00Z