Identification of a novel small molecule HIF-1alpha translation inhibitor.
about
HIF1A overexpression is associated with poor prognosis in a cohort of 731 colorectal cancers.KCN1, a novel synthetic sulfonamide anticancer agent: in vitro and in vivo anti-pancreatic cancer activities and preclinical pharmacologyStructure-activity relationship of 2,2-dimethyl-2H-chromene based arylsulfonamide analogs of 3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-N-phenylbenzenesulfonamide, a novel small molecule hypoxia inducible factor-1 (HIF-1) pathway inhibitInhibition of hypoxia-inducible factor-1alpha (HIF-1alpha) protein synthesis by DNA damage inducing agentsSulfonamides as a new scaffold for hypoxia inducible factor pathway inhibitors.MDM2 regulates hypoxic hypoxia-inducible factor 1α stability in an E3 ligase, proteasome, and PTEN-phosphatidylinositol 3-kinase-AKT-dependent manner.Blocking autocrine VEGF signaling by sunitinib, an anti-cancer drug, promotes embryonic stem cell self-renewal and somatic cell reprogramming.HIF1α regulated expression of XPA contributes to cisplatin resistance in lung cancer.Hypoxia-inducible factor-1α mRNA: a new target for destabilization by tristetraprolin in endothelial cells.Hypoxia, stem cells and bone tumorDesign and synthesis of novel small-molecule inhibitors of the hypoxia inducible factor pathwayRadio-sensitization effect of an mTOR inhibitor, temsirolimus, on lung adenocarcinoma A549 cells under normoxic and hypoxic conditions.Folic Acid Represses Hypoxia-Induced Inflammation in THP-1 Cells through Inhibition of the PI3K/Akt/HIF-1α PathwaySynthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1α inhibitors.Design and in vitro activities of N-alkyl-N-[(8-R-2,2-dimethyl-2H-chromen-6-yl)methyl]heteroarylsulfonamides, novel, small-molecule hypoxia inducible factor-1 pathway inhibitors and anticancer agents.Brain cancer propagating cells: biology, genetics and targeted therapiesDevelopment of Inhibitors Targeting Hypoxia-Inducible Factor 1 and 2 for Cancer Therapy.Targeting tumor hypoxia in nasopharyngeal carcinoma.Hypoxia inducible factor pathway inhibitors as anticancer therapeutics.Dysregulated pH in Tumor Microenvironment Checkmates Cancer Therapy.Hypoxia inducible factor 1α down regulates cell surface expression of α1,2-fucosylated glycans in human pancreatic adenocarcinoma cells.Hypoxia-inducible TAp73 supports tumorigenesis by regulating the angiogenic transcriptome.Lenticular cytoprotection. Part 1: the role of hypoxia inducible factors-1α and -2α and vascular endothelial growth factor in lens epithelial cell survival in hypoxia.Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1α interaction with cofactors p300/CBP.Hydrogen sulfide inhibits the translational expression of hypoxia-inducible factor-1α.Basal expression of copper transporter 1 in intestinal epithelial cells is regulated by hypoxia-inducible factor 2α.Binding Model for the Interaction of Anticancer Arylsulfonamides with the p300 Transcription Cofactor.Investigation on tumor hypoxia in resectable primary prostate cancer as demonstrated by 18F-FAZA PET/CT utilizing multimodality fusion techniquesInhibiting the hypoxia response for cancer therapy: the new kid on the block.HIF-1α- Targeting Acriflavine Provides Long Term Survival and Radiological Tumor Response in Brain Cancer Therapy.Transcription factors as critical players in melanoma invasiveness, drug resistance, and opportunities for therapeutic drug development.Altered expression of hypoxia-Inducible factor-1α participates in the epileptogenesis in animal models.Hypoxia induces pulmonary fibroblast proliferation through NFAT signaling.
P2860
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P2860
Identification of a novel small molecule HIF-1alpha translation inhibitor.
description
2009 nî lūn-bûn
@nan
2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Identification of a novel small molecule HIF-1alpha translation inhibitor.
@ast
Identification of a novel small molecule HIF-1alpha translation inhibitor.
@en
type
label
Identification of a novel small molecule HIF-1alpha translation inhibitor.
@ast
Identification of a novel small molecule HIF-1alpha translation inhibitor.
@en
prefLabel
Identification of a novel small molecule HIF-1alpha translation inhibitor.
@ast
Identification of a novel small molecule HIF-1alpha translation inhibitor.
@en
P2093
P2860
P1476
Identification of a novel small molecule HIF-1alpha translation inhibitor.
@en
P2093
Christine F Gelin
K C Nicolaou
Manuel Yepes
Shaoman Yin
Takuhito Narita
P2860
P304
P356
10.1158/1078-0432.CCR-08-3180
P407
P577
2009-09-29T00:00:00Z