Identification and characterization of the first small molecule inhibitor of MDMX
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Chemical Variations on the p53 Reactivation ThemeClinical Overview of MDM2/X-Targeted TherapiesTargeting the ubiquitin pathway for cancer treatmentSmall molecule compounds targeting the p53 pathway: are we finally making progress?Systematic Mutational Analysis of Peptide Inhibition of the p53–MDM2/MDMX InteractionsActivation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerizationThe p53 pathway as a target in cancer therapeutics: obstacles and promiseThe Double Role of p53 in Cancer and Autoimmunity and Its Potential as Therapeutic TargetA versatile platform to analyze low-affinity and transient protein-protein interactions in living cells in real timeOn the mechanism of action of SJ-172550 in inhibiting the interaction of MDM4 and p53The pharmacodynamics of the p53-Mdm2 targeting drug Nutlin: the role of gene-switching noiseDesign, Synthesis and Evaluation of 2,5-Diketopiperazines as Inhibitors of the MDM2-p53 InteractionA high-content screen identifies inhibitors of nuclear export of forkhead transcription factors.Diaryl- and triaryl-pyrrole derivatives: inhibitors of the MDM2-p53 and MDMX-p53 protein-protein interactions†Electronic supplementary information (ESI) available: Experimental details for compound synthesis, analytical data for all compounds and inAberrant activation of p53 due to loss of MDM2 or MDMX causes early lens dysmorphogenesis.Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.Novel pyrrolopyrimidine-based α-helix mimetics: cell-permeable inhibitors of protein−protein interactionsDIMP53-1: a novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties.EEF1A2 inactivates p53 by way of PI3K/AKT/mTOR-dependent stabilization of MDM4 in hepatocellular carcinoma.Organocatalytic, diastereo- and enantioselective synthesis of nonsymmetric cis-stilbene diamines: a platform for the preparation of single-enantiomer cis-imidazolines for protein-protein inhibition.MDM2, MDMX and p53 in oncogenesis and cancer therapyValidation of MdmX as a therapeutic target for reactivating p53 in tumorsA fluorescent-based high-throughput screening assay for small molecules that inhibit the interaction of MdmX with p53.PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS.Trophoblast induces monocyte differentiation into CD14+/CD16+ macrophagesHdmX overexpression inhibits oncogene induced cellular senescence.Blockade of Hsp90 by 17AAG antagonizes MDMX and synergizes with Nutlin to induce p53-mediated apoptosis in solid tumorsA small-molecule p53 activator induces apoptosis through inhibiting MDMX expression in breast cancer cells.TP53-Associated Pediatric Malignancies.Wild type p53 reactivation: from lab bench to clinic.Rational design of topographical helix mimics as potent inhibitors of protein-protein interactions.Fragment-based library generation for the discovery of a peptidomimetic p53-Mdm4 inhibitorSearching for Dual Inhibitors of the MDM2-p53 and MDMX-p53 Protein-Protein Interaction by a Scaffold-Hopping Approach.Translational approaches targeting the p53 pathway for anti-cancer therapy.Post-HTS case report and structural alert: Promiscuous 4-aroyl-1,5-disubstituted-3-hydroxy-2H-pyrrol-2-one actives verified by ALARM NMR.XI-006 induces potent p53-independent apoptosis in Ewing sarcoma.Nondenaturing polyacrylamide gel electrophoresis to study the dissociation of the p53·MDM2/X complex by potentially anticancer compounds.Towards an understanding of the role of p53 in adrenocortical carcinogenesis.Targeting the p53 signaling pathway in cancer therapy - the promises, challenges and perils.Computational studies of difference in binding modes of peptide and non-peptide inhibitors to MDM2/MDMX based on molecular dynamics simulations.
P2860
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P2860
Identification and characterization of the first small molecule inhibitor of MDMX
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Identification and characterization of the first small molecule inhibitor of MDMX
@ast
Identification and characterization of the first small molecule inhibitor of MDMX
@en
Identification and characterization of the first small molecule inhibitor of MDMX.
@nl
type
label
Identification and characterization of the first small molecule inhibitor of MDMX
@ast
Identification and characterization of the first small molecule inhibitor of MDMX
@en
Identification and characterization of the first small molecule inhibitor of MDMX.
@nl
prefLabel
Identification and characterization of the first small molecule inhibitor of MDMX
@ast
Identification and characterization of the first small molecule inhibitor of MDMX
@en
Identification and characterization of the first small molecule inhibitor of MDMX.
@nl
P2093
P2860
P50
P356
P1476
Identification and characterization of the first small molecule inhibitor of MDMX
@en
P2093
Aart G Jochemsen
Antonio M Ferreira
Brenda A Schulman
Catherine A Regni
David C Smithson
Donald Bashford
Fangyi Zhu
Michael A Dyer
Nicholas Mills
R Kiplin Guy
P2860
P304
10786-10796
P356
10.1074/JBC.M109.056747
P407
P577
2010-01-15T00:00:00Z