Blockade of Hsp90 by 17AAG antagonizes MDMX and synergizes with Nutlin to induce p53-mediated apoptosis in solid tumors
about
Caloric restriction: is mammalian life extension linked to p53?The Numb/p53 circuitry couples replicative self-renewal and tumor suppression in mammary epithelial cells.The p53 circuit boardPre-clinical validation of a selective anti-cancer stem cell therapy for Numb-deficient human breast cancers.MDM2, MDMX and p53 in oncogenesis and cancer therapyHuman glioblastoma multiforme: p53 reactivation by a novel MDM2 inhibitor.USP22 promotes NSCLC tumorigenesis via MDMX up-regulation and subsequent p53 inhibition.17-AAG suppresses growth and invasion of lung adenocarcinoma cells via regulation of the LATS1/YAP pathway.p53 protects against LPS-induced lung endothelial barrier dysfunction.p63 the guardian of human reproduction.Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax.Tumor suppressor PDCD4 modulates miR-184-mediated direct suppression of C-MYC and BCL2 blocking cell growth and survival in nasopharyngeal carcinoma.Role of apoptosis in colon cancer biology, therapy, and preventionThe Hsp90 inhibitor 17-(allylamino)-17-demethoxygeldanamycin increases cisplatin antitumor activity by inducing p53-mediated apoptosis in head and neck cancer.Scission of the p53-MDM2 Loop by Ribosomal Proteins.NRF2 and p53: Januses in cancer?Targeting p53-MDM2-MDMX loop for cancer therapy.Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia.Feedback modulation of neural network synchrony and seizure susceptibility by Mdm2-p53-Nedd4-2 signaling.The apoptotic effect and associated signalling of HSP90 inhibitor 17-DMAG in hepatocellular carcinoma cells.Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis.Molecular dynamics of the full-length p53 monomer.HSP90 Inhibitor Encapsulated Photo-Theranostic Nanoparticles for Synergistic Combination Cancer Therapy.Analysis of apoptosis methods recently used in Cancer Research and Cell Death & Disease publications.Mdm4 loss in mice expressing a p53 hypomorph alters tumor spectrum without improving survival.FBW7-Dependent Mcl-1 Degradation Mediates the Anticancer Effect of Hsp90 Inhibitors.The Roles of MDM2 and MDMX in Cancer.
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P2860
Blockade of Hsp90 by 17AAG antagonizes MDMX and synergizes with Nutlin to induce p53-mediated apoptosis in solid tumors
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Blockade of Hsp90 by 17AAG ant ...... ated apoptosis in solid tumors
@ast
Blockade of Hsp90 by 17AAG ant ...... ated apoptosis in solid tumors
@en
type
label
Blockade of Hsp90 by 17AAG ant ...... ated apoptosis in solid tumors
@ast
Blockade of Hsp90 by 17AAG ant ...... ated apoptosis in solid tumors
@en
prefLabel
Blockade of Hsp90 by 17AAG ant ...... ated apoptosis in solid tumors
@ast
Blockade of Hsp90 by 17AAG ant ...... ated apoptosis in solid tumors
@en
P2093
P2860
P356
P1476
Blockade of Hsp90 by 17AAG ant ...... ated apoptosis in solid tumors
@en
P2093
P2860
P2888
P356
10.1038/CDDIS.2011.39
P577
2011-05-12T00:00:00Z
P5875
P6179
1003118038